A5076905288- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- HER2/EGFR in Cancer Research
- Computational Drug Discovery Methods
- Evolution and Genetic Dynamics
- Computer Graphics and Visualization Techniques
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Malaria Research and Control
- Advanced Vision and Imaging
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Protein Degradation and Inhibitors
Central South University
2017-2024
Shandong Institute of Business and Technology
2023-2024
Zhejiang University
2015-2024
Alibaba Group (China)
2021-2024
Xiangya Hospital Central South University
2017-2024
Zhejiang Lab
2020-2024
Weatherford College
2024
Ministry of Education of the People's Republic of China
2011-2024
Shandong Provincial Hospital
2019-2024
Shandong University
2024
DIVERGE is a software system for phylogeny-based analyses of protein family evolution and functional divergence. It provides suite statistical tools selection prioritization the amino acid sites that are responsible divergence gene family. The synergistic efforts other methods have convincingly demonstrated pattern rate change at particular site may contain insightful information about underlying following duplication. These predicted be used as candidates further experiments. We now...
Objective— Increased level of plasma advanced oxidation protein products (AOPPs) has been found in patients with uremia and nonuremic subjects coronary artery disease. This study was conducted to test the hypothesis that AOPPs play a causal role atherosclerosis. Methods Results— Hypercholesterolemic (0.5% wt/wt diet) or normal rabbits received either repeated intravenous injections modified rabbit serum albumin (AOPPs-RSA) unmodified RSA for 8 weeks. Compared RSA- vehicle-treated...
Impacts of genetic and non-genetic intra-tumor heterogeneity (ITH) on tumor phenotypes evolvability remain debated. We analyze ITH in lung squamous cell carcinoma at the levels genome, transcriptome, tumor-immune interactions histopathological characteristics by multi-region bulk single-cell sequencing. Genomic alone is a weak indicator immune transcriptomic that impact multiple cancer-related pathways, including those related to proliferation inflammation, which turn contribute regional...
Neoantigens play important roles in cancer immunotherapy. Current methods used for neoantigen prediction focus on the binding between human leukocyte antigens (HLAs) and peptides, which is insufficient high-confidence prediction. In this study, we apply deep learning techniques to predict neoantigens considering both possibility of HLA-peptide (binding model) potential immunogenicity (immunogenicity peptide-HLA complex (pHLA). The model achieves comparable performance with other...
Abstract Tumor-specific neoantigens have attracted much attention since they can be used as biomarkers to predict therapeutic effects of immune checkpoint blockade therapy and potential targets for cancer immunotherapy. In this study, we developed a comprehensive tumor-specific neoantigen database (TSNAdb v1.0), based on pan-cancer immunogenomic analyses somatic mutation data human leukocyte antigen (HLA) allele information 16 tumor types with 7748 samples from The Cancer Genome Atlas (TCGA)...
Nursing professional identity is an important factor in the development of nursing education and clinical practice. Career-planning curriculums enable students to learn relevant knowledge skills a targeted manner, addition achieve career targets. Assessment analysis present situation Chinese students’ planning may provide guidance for improvement teaching content quality career-planning curriculum. This study aimed describe identity, find out influences planning, internship experience, other...
Abstract Bystander‐killing payloads can significantly overcome the tumor heterogeneity issue and enhance clinical potential of antibody‐drug conjugates (ADC), but rational design identification effective bystander warheads constrain broader implementation this strategy. Here, graph attention networks (GAT) are constructed for a killing scoring model ADC construction workflow first time. To generate efficient bystander‐killing payloads, is utilized score‐directed exatecan derivatives design....
Accumulation of plasma advanced oxidation protein products (AOPP) has been found in patients with chronic kidney disease. However, the biologic consequences AOPP consumption on progression renal disease still are unclear. For testing hypothesis that accelerate disease, Sprague-Dawley rats were subjected to five-sixths nephrectomy (5/6 Nx) or sham operation. Rats each group randomly assigned three subgroups (n = 30 group) and treated repeated intravenous injections AOPP-modified rat serum...
The involvement of inflammatory processes has been recognized in development and/or progression diabetic nephropathy. However, the mechanisms involved pathogenesis renal inflammation have not completely understood. In this study, we tested hypothesis that accumulation advanced oxidation protein products (AOPPs), which occurs diabetes, may promote responses kidney. Streptozotocin-induced rats were randomized to iv injection vehicle, native rat serum albumin (RSA), and AOPPs-modified RSA...
BACKGROUND: MicroRNAs (miRNAs) emerge as important regulators involved in malignant progression some tumors. MiR-181a has been found to function a tumor suppressor tumors including non-small cell lung cancer (NSCLC). However, the functional role of miR-181a NSCLC still needed be investigated. METHODS: The expression were determined by qRT-PCR, association between and clinicopathological data performed chi-square test survival analysis evaluated Kaplan-Meier curve log rank test. Cell...
Tumour antigens have attracted much attention because of their importance to cancer diagnosis, prognosis and targeted therapy. With the development genomics, identification tumour-specific neoantigens became possible, which is a crucial step for immunotherapy. In this study, we developed software called neoantigen detector detecting somatic mutations following best practices genome analysis toolkit predicting potential neoantigens, could be either extracellular membrane proteins or mutated...
Activation of intrarenal renin-angiotensin system (RAS) has a detrimental effect on the progression chronic kidney diseases (CKDs), although regulation RAS remains unclear. The aim present study was to evaluate role advanced oxidation protein products (AOPPs) in activation.AOPPs upregulated expression almost all components and increased activity angiotensin-converting enzyme cultured proximal tubular epithelial cells. triggering AOPP-albumin 100-times stronger than that unmodified albumin....
Abstract Background Streptomycetes are filamentous soil-dwelling bacteria. They best known as the producers of a great variety natural products such antibiotics, antifungals, antiparasitics, and anticancer agents decomposers organic substances for carbon recycling. also model organisms studies gene regulatory networks, morphological differentiation, stress response. The availability sets genomes from closely related Streptomyces strains makes it possible to assess mechanisms underlying...
LY2874455 can avoid a steric clash with the mutated gatekeeper residue in FGFR4.
Biochemical and structural studies provide information on the mode of action FGF401 as a selective, reversible covalent inhibitor FGFR4.
Abstract Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of cancer. However, little known about the genomic features this disease. We perform whole-exome sequencing analysis AFPGC, identify 34 significantly mutated genes. Somatic copy number alterations reveals several significant focal amplifications (e.g. 19q12, 17q12) deletions 1p36.11, 9p21.3), some these negatively affect patient prognosis. Comparative analyses reveal that AFPGC has distinct from...
Forkhead transcription factors bind a canonical consensus DNA motif, RYAAAYA (R = A/G, Y C/T), as monomer. However, the molecular mechanisms by which forkhead dimer are not well understood. In this study, we show that FOXO1 recognizes palindromic element DIV2, and mediates transcriptional regulation. The crystal structure of FOXO1/DIV2 reveals binding domain (DBD) binds DIV2 site homodimer. wing1 region dimerization, enhances affinity complex stability. Further biochemical assays FOXO3,...
Abstract Motivation Identifying genes that play a causal role in cancer evolution remains one of the biggest challenges biology. With accumulation high-throughput multi-omics data over decades, it becomes great challenge to effectively integrate these into identification driver genes. Results Here, we propose MODIG, graph attention network (GAT)-based framework identify by combining pan-cancer (mutations, copy number variants, gene expression and methylation levels) with multi-dimensional...