A5084621264- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Congenital Heart Disease Studies
- Aquaculture Nutrition and Growth
- Cardiac Structural Anomalies and Repair
- Liver physiology and pathology
- Aortic Disease and Treatment Approaches
- Animal Disease Management and Epidemiology
- Ferroptosis and cancer prognosis
- Pediatric health and respiratory diseases
- Traditional Chinese Medicine Analysis
- Genomics and Chromatin Dynamics
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Viral Infections and Vectors
- FOXO transcription factor regulation
- Immune responses and vaccinations
- Toxoplasma gondii Research Studies
- Marine Toxins and Detection Methods
- Pregnancy and Medication Impact
- Pediatric Urology and Nephrology Studies
- Adversarial Robustness in Machine Learning
- Coconut Research and Applications
- Sports, Gender, and Society
- Burkholderia infections and melioidosis
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Changzhou University
2024
Dalian Medical University
2023
Huazhong Agricultural University
2023
Affiliated Hospital of Nantong University
2022
Nantong University
2022
Chinese PLA General Hospital
2015-2021
PLA Academy of Military Science
2020
Zhejiang Normal University
2020
Forkhead transcription factors bind a canonical consensus DNA motif, RYAAAYA (R = A/G, Y C/T), as monomer. However, the molecular mechanisms by which forkhead dimer are not well understood. In this study, we show that FOXO1 recognizes palindromic element DIV2, and mediates transcriptional regulation. The crystal structure of FOXO1/DIV2 reveals binding domain (DBD) binds DIV2 site homodimer. wing1 region dimerization, enhances affinity complex stability. Further biochemical assays FOXO3,...
Hyperactive c-Met signaling pathway caused by altered MET is a common mechanism underlying gastric cancer and represents an attractive target for the treatment of with alterations. However, no kinase inhibitors are currently approved specifically c-Met-amplified cancer. Recently, bozitinib, highly selective inhibitor, has shown remarkable potency in selectively inhibiting MET-altered non-small cell lung secondary glioblastoma. In this study, we investigate antitumor activity bozitinib...
Herpesviruses or herpesviral sequences have been identified in various bat species. Here, we report the isolation, cell tropism, and complete genome sequence of a novel betaherpesvirus from Miniopterus schreibersii (MsHV). In primary culture, MsHV causes cytopathic effects (CPE) reaches peak virus production 2 weeks after infection. was found to infect replicate less efficiently feline kidney cell, CRFK, failed 13 other lines tested. Sequencing using 454 system, with 224-fold coverage,...
The current research was aimed to determine the impacts of cottonseed meal substitution levels for fishmeal on growth performance, immune indices, antioxidant ability, and muscle texture red swamp crayfish (Procambarus clarkii). Five isonitrogenous isolipidic diets were formulated feed 8 weeks. basal diet contained 20% (FM), while other four experimental substituted in FM with at 25%, 50%, 75%, 100%, referred as CM25, CM50, CM75, CM100 respectively. A total 750 an average initial weight 4.00...
Pneumonectomy is a proven treatment for lung diseases. We sought to present comparison between video-assisted thoracic surgery pneumonectomy (VATS-P) and conventional thoracotomy (CP) on perioperative outcomes short-term measures of convalescence.A retrospective cohort study was performed assess among patients underwent VATS-P CP. A total 32 undergoing were matched 2:1 about comorbidity, surgical indication, tumour size lesion location previous 64 who Demographic data obtained. Statistical...
Objective We aimed to identify the clinical factors associated with lymph node metastasis (LNM) based on ultrasound characteristics and data, develop a nomogram for personalized decision-making. Methods A retrospective analysis was performed 252 patients papillary thyroid carcinoma (PTC). The patient’s information subjected univariate multivariate logistic regression analyses risk factors. predict LNM established combining performance of evaluated using receiver operating characteristic...
This study aimed to evaluate the role of surgical left atrial appendage (LAA) exclusion in prevention stroke after mitral valve replacement (MVR).We retrospectively reviewed clinical data 860 patients who received MVR our center from January 2008 2013. The were randomly assigned two groups, namely LAA group (n = 521) and nonexclusion 339) according whether concurrent was be undertaken or not before surgery a blind fashion. performed by experienced surgeons. explored during operation mural...
Lonicera japonica is a traditional Chinese herbal medicine with antioxidation, anti‐inflammatory, antibacterial, and immunoregulation functions. A method to isolate polysaccharides from (LJP) has been reported previously by our group. We also that LJP was consisted of 6 types monosaccharides had the characteristic absorption typical polysaccharides. In this study, we investigated protective effect on cardiomyocytes mice injured hydrogen peroxide (H 2 O ). The results showed can increase...
Hepatocellular carcinoma (HCC) is one of the most general malignant tumors. Hypoxia a critical clinical characteristic and acts as significant part in development cancers’ prognosis. The prognostic value biological functions hypoxia-related lncRNAs hepatocellular little known. Thus, we aim to establish lncRNA signature predict HCC patients’ survival. First, extracted genes expression from MSigDB TCGA database, respectively. co-expression analysis among mRNAs was employed identify lncRNAs....
Brucellosis is a common zoonotic infection worldwide and major public health problem in developing countries including China. The aim of our study was to investigate the seroprevalence Brucella humans Yixing, located at centre Yangtze River Delta Urban Agglomeration. A total 895 sera from apparently healthy abattoir workers 3303 general people living rural areas were collected screened by Rose-Bengal plate agglutination test (RBPT) positives confirmed standard tube (SAT) according official...
The Internet of Things (IoT) transmits data between devices and users with the help communication protocols. IoT protocols can be classified into 3 architecture kinds from different aspects: OSI model hierarchy, IEEE 802 protocol standard or network types. Designed for diverse situation growing technique, show features in technology roadmap, distance, signal frequency spectrum rang. future trends might locate their optimization, integration information security.
Objectives: Aim to find the epidemiological and aetiological characteristics of hand, foot mouth disease (HFMD) cases in Yixing.Methods: All HFMD reported China information for control prevention system 2011–2017 were analysed. Rectal throat swab samples randomly selected detected by RT-PCR recognize pathogenic agent: CoxasckievirusA16 (CA16), Enterovirus 71 (EV71) or other human enterovirus. SPSS 22.0 software packages used analyse samples.Results: Seventeen thousand seven hundred...
Atrioventricular septal defect (AVSD) accounts for up to 3 % of congenital cardiac defects, which is routinely repaired via median sternotomy. Minimally invasive approach such as endoscopic or robotic assisted repair AVSD has not been reported in the literature. With experience with mitral valve surgery and repair, we initiated adults. In this report, presented three cases successful partial intermediate by using da Vinci SI surgical system (Intuitive Surgical, Inc., Sunnyvale, CA). Totally...
Cor triatriatum sinister (CTS) is a rare congenital cardiac anomaly and mainly corrected through conventional surgery sternotomy. We described our successful novel surgical technique of totally robotic correction CTS in one case with concomitant repair atrial septal defect using da Vinci SI Surgical System (Intuitive Surgical, Inc, Sunnyvale, CA USA) excellent outcome. conclude that feasible safe alternative to technique.