Chunfang Zhang

ORCID: 0009-0007-1731-6342
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Research Areas
  • Lung Cancer Diagnosis and Treatment
  • Pulmonary Hypertension Research and Treatments
  • Ferroptosis and cancer prognosis
  • Metastasis and carcinoma case studies
  • Lung Cancer Treatments and Mutations
  • Pleural and Pulmonary Diseases
  • RNA modifications and cancer
  • Sarcoma Diagnosis and Treatment
  • Venous Thromboembolism Diagnosis and Management
  • Respiratory Support and Mechanisms
  • Acute Ischemic Stroke Management
  • Urinary Bladder and Prostate Research
  • Gastric Cancer Management and Outcomes
  • Cancer-related molecular mechanisms research
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Monoclonal and Polyclonal Antibodies Research
  • Cerebrovascular and Carotid Artery Diseases
  • Neurological Disease Mechanisms and Treatments
  • Cancer Diagnosis and Treatment
  • Botulinum Toxin and Related Neurological Disorders
  • Cardiac tumors and thrombi
  • Workplace Health and Well-being
  • Cancer, Stress, Anesthesia, and Immune Response
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Inflammatory Biomarkers in Disease Prognosis

117th Hospital of People's Liberation Army
2025

Central South University
2009-2025

Xiangya Hospital Central South University
2009-2025

Hunan Xiangdian Test Research Institute (China)
2025

Pudong New Area People's Hospital
2021-2024

Hebei University
2024

The First People’s Hospital of Lianyungang
2019-2024

Hunan Academy of Traditional Chinese Medicine
2022

Xuzhou Medical College
2019-2022

Lianyungang Oriental Hospital
2022

BACKGROUND. Current clinical management of patients with pulmonary nodules involves either repeated low-dose CT (LDCT)/CT scans or invasive procedures, yet causes significant patient misclassification. An accurate noninvasive test is needed to identify malignant and reduce unnecessary tests.

10.1172/jci145973 article EN Journal of Clinical Investigation 2021-04-01

Background Cancer, influenced by genetics and the environment, involves anoikis, a cell death mechanism upon extracellular matrix detachment crucial for metastasis. Understanding this relationship is key therapy. We analyze cancer anoikis trends using bibliometrics.

10.1080/20565623.2025.2484159 article EN cc-by-nc Future Science OA 2025-03-31

Abstract This study aimed to comprehensively evaluate the diagnostic potential of urinary exosomal microRNA (miRNA) in IgA vasculitis (IgAV) kidney injury by meticulously comparing miRNA expression profiles urine exosomes between children diagnosed with IgAV and those nephritis (IgAVN). Urine samples were obtained from who treated at our hospital October 2022 2023. These then categorized into group IgAVN group. High‐throughput sequencing bioinformatics analysis techniques employed conduct a...

10.1096/fj.202403111r article EN cc-by-nc-nd The FASEB Journal 2025-04-01

The reconstruction of pulmonary vascular structure caused by the proliferation and migration arterial smooth muscle cells (PASMCs) is central link in formation hypertension (PAH). Platelet‑derived growth factor (PDGF) can regulate PASMCs. At same time, nuclear factor activated T cells (NFATs) plays an important role development PAH. To best our knowledge, there are no reports yet regarding whether PDGF regulates NFATc2 to increase present study aimed investigate affects...

10.3892/mmr.2020.11677 article EN cc-by-nc-nd Molecular Medicine Reports 2020-11-10

To evaluate the sensitivity of electrophysiologic assessments, we compared F-waves and motor sensory nerve conduction studies (MNCS SNCS) in patients with diabetes mellitus (DM).We tested median, ulnar, tibial, fibular nerves 132 DM divided into those without clinical evidence polyneuropathy.Of 64 asymptomatic patients, 2 (3%) had MNCS or SNCS abnormalities, both whom F-wave changes, whereas 21 (33%) only delayed F-waves, for a combined yield 23 (36%). The corresponding values 68 symptomatic...

10.1002/mus.24127 article EN Muscle & Nerve 2013-11-21

Abstract Background Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment risk intracranial ischemic stroke (IS). We present the design fourth INTEnsive ambulance-delivered Reduction hyper-ACute Trial (INTERACT4). Methods A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed...

10.1186/s13063-021-05860-y article EN cc-by Trials 2021-12-01

Pneumonectomy is a proven treatment for lung diseases. We sought to present comparison between video-assisted thoracic surgery pneumonectomy (VATS-P) and conventional thoracotomy (CP) on perioperative outcomes short-term measures of convalescence.A retrospective cohort study was performed assess among patients underwent VATS-P CP. A total 32 undergoing were matched 2:1 about comorbidity, surgical indication, tumour size lesion location previous 64 who Demographic data obtained. Statistical...

10.21037/jtd.2016.12.24 article EN Journal of Thoracic Disease 2016-12-01

Aim To evaluate protein expression and clinical significance of PLAC1/CP1 antigen in primary gastric adenocarcinoma. Methods Protein was analysed by tissue chip immunohistochemistry surgical specimens obtained from 119 patients with cancer. The data were using SPSS V.16.0 software applying the χ 2 test Kaplan-Meier method. Results positive frequency 61.3% (73/119 patients). overall survival protein-positive significantly lower than that protein-negative (p<0.05). There no significant...

10.1136/jclinpath-2015-202978 article EN Journal of Clinical Pathology 2015-07-08

Abstract Background and aims Uncertainty persists over the effects of blood pressure (BP) lowering in acute stroke. The INTEnsive ambulance-delivered Reduction hyper-Acute stroke Trial (INTERACT4) to determine efficacy safety hyperacute intensive BP patients with suspected Given concerns this treatment pre-hospital setting, particularly relation intracerebral hemorrhage, we provide an update on progress study profile participants date. Methods INTERACT4 is ongoing multicentre,...

10.1186/s13063-023-07861-5 article EN cc-by Trials 2023-12-20

Graphene oxide (GO) is widely used in bone tissue engineering due to its good biocompatibility and proliferation, often combination with other hydrogels, which not only reduces the cytotoxicity of GO but also improves mechanical properties hydrogels. We developed injectable carboxymethyl chitosan (CMC)/hydroxyethyl cellulose (HEC)/β-tricalcium phosphate (β-TCP)/GO hydrogel via hydrogen bonding cross-linked between (CMC) (HEC), also, calcium by β-TCP was involved further improvement hydrogel,...

10.1080/09205063.2024.2397211 article EN Journal of Biomaterials Science Polymer Edition 2024-09-03

Sepsis is a life-threatening situation, and it can be rendered more severe by coagulopathy. We here examine novel plasma biomarker for sepsis-induced coagulopathy.A total of 116 patients diagnosed with sepsis were recruited divided into two groups whether they also had Plasma samples collected on arrival at the intensive care unit. Fifteen sepsis-alone 15 coagulopathy mixed sent microRNA sequencing. Differently expressed microRNAs then validated quantitative reverse transcriptase polymerase...

10.1186/s12879-020-4853-y article EN cc-by BMC Infectious Diseases 2020-02-19

<i>Objectives:</i> To evaluate the prevalence, risk factors of nocturia and nocturia-related quality life. <i>Methods:</i> Age, hypertension, cardiovascular disease, diabetes mellitus, benign prostatic hyperplasia (BPH), alcohol abuse smoking were analyzed using logistic analysis. Multiple linear-regression analysis was used to identify predicting score on Nocturia Quality Life (N-QOL) questionnaire.<i> Results:</i> 1,198 adults completed this study. 411...

10.1159/000321895 article EN Urologia Internationalis 2011-01-01

The benefits of physical activity are well known, but little is known about the views elderly Chinese people regarding activity, and what factors affect this. This qualitative study aims to explore experiences perceptions community gain a better understanding these. A 12 was undertaken using Colaizzi phenomenological approach semi-structured interviews gather data. Three key themes emerged relating current status, beliefs influencing activity. provides new knowledge community's By these, we...

10.12968/bjcn.2013.18.7.340 article EN British Journal of Community Nursing 2013-07-01

Purpose To construct a scoring system to differentiate malignant liposarcomas from benign lipomas by comparing their clinical and magnetic resonance imaging (MRI) features. Methods Clinical MRI features of 33 women men aged 17 83 (mean, 53) years who underwent resection (n=32) or (n=34) were reviewed. Results The 5 strongest predictors liposarcoma male gender, larger tumour maximum dimension, deep fascia, thick non-fatty septum nodule, internal cystic change. A weighted was constructed using...

10.1177/1602400219 article EN cc-by-nc Journal of orthopaedic surgery 2016-08-01

Pulmonary artery enlargement is a common manifestation of chest CT in patients with pulmonary arterial hypertension (PAH). The exact clinical significance this phenomenon has not been clarified connective tissue disease (CTD)-associated PAH (CTD-PAH). We aimed to explore the association between dilatation and prognosis CTD-PAH patients.We retrospectively investigated 140 diagnosed by echocardiography from 2009 2018. A multi-slice was performed on all patients. Main (MPA), right (RPA), left...

10.1093/rheumatology/keaa100 article EN Lara D. Veeken 2020-02-12
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