A5043655160- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Plant Virus Research Studies
- Circular RNAs in diseases
- Vascular Malformations Diagnosis and Treatment
- Forensic Toxicology and Drug Analysis
- EEG and Brain-Computer Interfaces
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Coronary Interventions and Diagnostics
- Non-Invasive Vital Sign Monitoring
- Infectious Encephalopathies and Encephalitis
- Retinal and Optic Conditions
- Spinal Hematomas and Complications
- Cardiac Imaging and Diagnostics
- Plant Pathogens and Resistance
University of California, Irvine
2006-2024
Arcadia
2024
Neurology, Inc
2020-2023
University of California, Irvine Medical Center
2007-2022
University Medical Center Utrecht
2021
Capital Medical University
2011-2021
Beijing Tian Tan Hospital
2021
WengFu Group (China)
2017-2020
UC Irvine Health
2020
CHOC Foundation
2019
Background and Purpose— The WEAVE trial (Wingspan Stent System Post Market Surveillance) is a postmarket surveillance mandated by the Food Drug Administration to assess periprocedural safety of Wingspan system in treatment symptomatic intracranial atherosclerotic disease. Methods— A total 152 consecutive patients who met on-label usage criteria were enrolled at 24 hospitals underwent angioplasty stenting with stent. On-label included age 22 80 years, stenosis 70% 99%, baseline modified...
<h3>BACKGROUND AND PURPOSE:</h3> Convolutional neural networks are a powerful technology for image recognition. This study evaluates convolutional network optimized the detection and quantification of intraparenchymal, epidural/subdural, subarachnoid hemorrhages on noncontrast CT. <h3>MATERIALS METHODS:</h3> was performed in 2 phases. First, training cohort all NCCTs acquired at single institution between January 1, 2017, July 31, used to develop cross-validate custom hybrid 3D/2D mask...
<h3>Importance</h3> In-stent restenosis (ISR) is the primary reason for stroke recurrence after intracranial stenting in patients who were treated with a standard bare-metal stent (BMS). Whether drug-eluting (DES) could reduce risk of ISR atherosclerotic stenosis (ICAS) remains unclear. <h3>Objective</h3> To investigate whether DES can and symptomatic high-grade ICAS. <h3>Design, Settings, Participants</h3> A prospective, multicenter, open-label randomized clinical trial blinded outcome...
Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon angioplasty has been investigated in a trial.
Background Prior studies evaluating the Wingspan stent for treatment of symptomatic intracranial atherosclerotic disease have included patients with a spectrum both on-label and off-label indications stent. The WEAVE trial assessed 152 stented strictly by its current indication found 2.6% periprocedural stroke death rate. Objective This WOVEN study assesses 1-year follow-up from this cohort. Methods Twelve original 24 sites enrolling in performed chart review imaging analysis up to 1 year...
There were limited data on the long-term outcome of patients with symptomatic intracranial atherosclerotic stenosis ≥70% after Wingspan stenting. Using our cohort and from Warfarin Aspirin for Symptomatic Intracranial Atherosclerotic Disease (WASID) as a historical control, we tested hypothesis that stenting provided no benefit over antithrombotic therapy alone these high-risk patients.Between January 2007 February 2009, 100 consecutive symptoms within 90 days enrolled into this prospective...
Clinical methods have incomplete diagnostic value for early diagnosis of acute stroke and large vessel occlusion (LVO). Electroencephalography is rapidly sensitive to brain ischemia. This study examined the utility electroencephalography stroke/transient ischemic attack (TIA) LVO.Patients (n=100) with suspected in an emergency department underwent clinical exam then using a dry-electrode system. Four models classified patients, first as stroke/TIA or not, LVO not: (1) data, (2) (3)...
Eighteen patients underwent stenting for symptomatic basilar artery stenosis. There were three major periprocedural complications (16.7%) without fatality. At a mean 26.7 ± 12.1-month follow-up, 15 (83.3%) had an excellent long-term outcome. Only one patient (5.6%) moderate disability from recurrent stroke, and two died of medical illness at 30 36 months after stenting. In this uncontrolled study, appeared to be effective in reducing stroke risk death worthy further scrupulous trial.
Background Point-of-care (POC) MRI is a bedside imaging technology with fewer than five units in clinical use the United States and paucity of scientific studies on applications. Purpose To evaluate operational impacts deploying POC emergency department (ED) intensive care unit (ICU) patient settings for neuroimaging, including turnaround time. Materials Methods In this preliminary retrospective study, all patients ED ICU at single academic medical center who underwent noncontrast brain from...
Despite the availability of commercial artificial intelligence (AI) tools for large vessel occlusion (LVO) detection, there is paucity data comparing traditional machine learning and deep solutions in a real-world setting. The purpose this study to compare validate performance two AI-based (RAPID LVO CINA LVO) detection.This was retrospective, single center performed at comprehensive stroke from December 2020 June 2021. CT angiography (n = 263) suspected were evaluated LVO. RAPID model which...
Purpose Automated large vessel occlusion (LVO) tools allow for prompt identification of positive LVO cases, but little is known about their role in acute stroke triage when implemented a real-world setting. The purpose this study was to evaluate the automated detection tool’s impact on workflow and clinical outcomes. Materials methods Consecutive patients with computed tomography angiography (CTA) presenting suspected ischemic were compared before after implementation an AI tool, RAPID...
In 2004, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) began certifying primary stroke centers.1 Certification requires adoption guidelines,2 including standardized performance measures. The University California Irvine Medical Center (UCIMC) was in initial group five hospitals certified, January 2004. UCIMC is only Level 1 trauma center and university medical Orange County, California, fifth most populous US county.3 hospital has 462 beds, a 7-bed neuroscience...
Thrombosis of the cerebral venous sinus may cause congestion, edema, and infarction. The role cerebrovenous disorders in arterial ischemic stroke is unknown. objective this study was to examine contribution ipsilateral cranial abnormalities development edema middle artery infarction.This a retrospective consecutive patients with large infarction admitted our neurocritical care unit from January 2007 October 2008. Medical records, laboratory data, imaging sinuses were analyzed.Of 14...
Abstract Background Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment risk intracranial ischemic stroke (IS). We present the design fourth INTEnsive ambulance-delivered Reduction hyper-ACute Trial (INTERACT4). Methods A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed...
Background and aim High resolution MR imaging (HRMRI) has been used to study intracranial atherosclerotic plaques. How HRMRI guided our decision making process in endovascular intervention of basilar artery (BA) disease is reported. Methods 3 patients with symptomatic BA underwent wall under a T scanner. Endovascular was then performed utilizing findings guide therapy aid planning the intervention. Results clearly identified eccentric plaque at opposite side adjacent right anterior inferior...
Background An in situ recanalization procedure of endovascular therapy (ET) or carotid endarterectomy (CEA) has been attempted patients with symptomatic chronic internal artery occlusions (ICAOs), though the rates both are low. Objective To investigate outcomes Multimodality In Recanalization for ICAOs a Hybrid Operating Room (MIRHOR) at same session. Methods Symptomatic were classified into type A B (short occlusion without tapered residual root [TRR]), and C D (long TRR), managed hybrid...