A5010847729- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- interferon and immune responses
- Peripheral Artery Disease Management
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Neurological Disease Mechanisms and Treatments
- Cardiac Ischemia and Reperfusion
- Advanced biosensing and bioanalysis techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Amino Acid Enzymes and Metabolism
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Congenital heart defects research
- Advanced Electron Microscopy Techniques and Applications
Kobe University
2025
Soochow University
2018-2024
Chinese People's Liberation Army
2014-2021
Air Force General Hospital PLA
2018
Beijing Tian Tan Hospital
2006-2015
Second Artillery General Hospital of Chinese People's Liberation Army
2013-2015
Capital Medical University
2007-2015
Affiliated Hospital of Nantong University
2011
The University of Texas Southwestern Medical Center
2011
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
There were limited data on the long-term outcome of patients with symptomatic intracranial atherosclerotic stenosis ≥70% after Wingspan stenting. Using our cohort and from Warfarin Aspirin for Symptomatic Intracranial Atherosclerotic Disease (WASID) as a historical control, we tested hypothesis that stenting provided no benefit over antithrombotic therapy alone these high-risk patients.Between January 2007 February 2009, 100 consecutive symptoms within 90 days enrolled into this prospective...
Dexmedetomidine displays multiple mechanisms of neuroprotection in ameliorating ischemic brain injury.In this study, we explored the beneficial effects dexmedetomidine on blood-brain barrier (BBB) integrity and neuroinflammation cerebral ischemia/reperfusion injury.Sprague-Dawley rats were subjected to middle artery occlusion (MCAO) for 1.5 h reperfusion 24 establish a rat model injury.Dexmedetomidine (9 g/kg) was administered 30 min after MCAO through intravenous injection, SB203580 (a p38...
ABSTRACT Aim Strokes are the second most common cause of mortality and disability worldwide. Ischemic strokes account for main part strokes. Recently, epigenetic changes that occur during biological aging through DNA methylation have gained attention. The National Institutes Health Stroke Scale (NIHSS) scores measure physical cognitive function. We hypothesized there associations between acute in NIHSS score patients with ischemic stroke. conducted clock analyses to investigate association...
Abstract Ischemia-reperfusion injury (IRI) is an important cause of adverse prognosis after recanalization in patients with acute occlusion major intracranial artery (AOMIA). Here, we provided data indicating that gradual flow restoration (GFR) would be superior to rapid (RFR) alleviating cerebral IRIs middle (MCAO) rats. A total 94 MCAO rats 15, 30 and 60-minute were randomly assigned receive either GFR or RFR intervention. There significant differences between group mean neurological...
Abstract The corresponding hemodynamic changes of the internal carotid artery (ICA) after revascularization surgery for moyamoya disease (MMD) remain unclear. aim this study was to analyze ipsilateral ICA combined direct and indirect extracranial-intracranial (EC-IC) bypass. MMD patients undergoing EC-IC bypass were retrospectively reviewed. mean transit time (MTT) evaluated by color-coding angiography before at follow-up. MTT defined as blood between end cervical portion (C1) C7 segment...
Seventy-nine consecutive patients with symptomatic atherosclerotic stenosis ≥ 50% of intracranial vertebrobasilar artery (VBA) were treated by elective stenting. There five strokes within 30 days, and three in the VBA territory after days (mean 812 days). The annual stroke rate (including any death days) was 4.6%. At last follow-up time, 73 independent (modified Rankin scale grade ≤ 2). outcome compares favorably medical therapy.
In 2015, 5 randomized controlled trials (RCTs) independently demonstrated the safety and efficacy of EVT for AIS from large vessel occlusion (LVO) in anterior circulation within 6-12 hours symptom onset, a result later confirmed by 3 other trials. early 2018, 2 additional RCTs extended time window to 16-24 hours. However, there were great variabilities use imaging tools patient selection RCTs. The goal this review is appraise modalities used landmark studies propose simple efficient protocol...
Neural crest defects lead to congenital heart disease involving outflow tract malformation. Integrin-linked-kinase (ILK) plays important roles in multiple cellular processes and embryogenesis. ILK is expressed the neural crest, but its role morphogenesis remains unknown.We ablated specifically using Wnt1-Cre transgene. ablation resulted abnormal migration overpopulation of cells pharyngeal arches a significant reduction expression cell adhesion molecule (NCAM) extracellular matrix...
To investigate the safety of triple antiplatelet therapy (TAT) with cilostazol in patients undergoing stenting for extracranial and/or intracranial artery stenosis.A prospectively collected database was reviewed to identify who underwent stenosis and showed resistance aspirin clopidogrel as assessed by pre-stenting thromboelastography (TEG) testing. Patients were assigned a TAT group dual (DAT) group. Major complications defined thromboembolic events (transient ischemic attack (TIA), stroke,...
Abstract Background and purpose: Analysis of dynamic cerebral autoregulation during transient falls in blood pressure is considered a sensitive convenient method for evaluating patients with carotid artery stenosis. To this point, there have been few reports on the efficacy using thigh cuffs technique to analyse middle (MCA) If it could be determined whether flow can maintained (autoregulated) sudden arterial (ABP), then might possible identify MCA stenosis who are at risk stroke. Methods:...
Abstract The prominent vessel sign (PVS) on susceptibility-weighted imaging (SWI) is not displayed in all cases of acute ischemia. We aimed to investigate the factors associated with presence PVS stroke patients. Consecutive ischemic patients admitted within 24 h from symptom onset underwent emergency multimodal MRI at admission. Associated for were analyzed using univariate analyses and multivariable logistic regression analyses. A total 218 enrolled. occurrence rate was 55.5%. Univariate...
Futile recanalization (FR) is defined as patients with acute ischemic stroke (AIS) due to large vessel occlusion who still exhibits functional dependence although undergoing successful mechanical thrombectomy (MT). We aimed develop and validate a simple nomogram for predicting the probability of FR after MT treatment in AIS patients.
<h3>SUMMARY:</h3> We evaluated the intraobserver and interobserver variability for WA measurement of an atherosclerotic BA by using HRMRI. Ten consecutive patients underwent HRMRI, at level trigeminal ganglion was measured 2 independent readers repeated 1 reader month later. There strong agreement measurements in ICC Bland-Altman method. Measurement HRMRI reproducible.
The extended time window and theoretic reduction in hemorrhage make mechanical strategies an attractive approach for the treatment of patients with ischemic stroke. However, a limited availability suitable animal models cerebrovascular thrombosis has hampered study novel endovascular interventions. aim present was to develop new technique site-specific placement thrombus canine model that would allow evaluation thrombectomy clot retrieval methods visualization dislocation or fragmentation...
421 Dr. V. Puetz, Department of Neurology Technical University Dresden, Fetscherstrasse 74 DE–01307 Dresden (Germany) Tel. +49 351 458 3565, Fax 4365 E-Mail volker.puetz@neuro.med.tu-dresden.de 9 Hacke W, Albers G, Al-Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, Fischer Furlan Kaste Lees KR, Soehngen Warach S; DIAS Study Group: The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. 2005; 36:...
The aim of this study is to identify the peri-procedural risk factors and outcomes hemodynamic instability (HI) after carotid artery stenting (CAS).A single-center, retrospective was performed in 168 patients who underwent CAS procedure between September 2017 2020. presence HI, as defined by hypertension (systolic blood pressure >160 mmHg), hypotension <90 and/or bradycardia (heart rate <60 bpm), recorded. Long-period HI persistent lasting more than 24 h. Patient demographics, comorbidities,...
Endovascular recanalization (ER) has demonstrated efficacy as a treatment modality for patients presenting with acute ischemic stroke (AIS) caused by large-vessel occlusion (LVO) within 24-hour timeframe. Nevertheless, the safety and effectiveness of ER in time onset exceeding 24 h remain uncertain.
Objective To evaluate the recanalization efficacy and safety of a novel stent retriever in swine model acute arterial occlusion. Methods The JRecan thrombectomy device, with weaving design, was evaluated 18 occluded cervicocerebral vessels swine. flow restoration effect immediately upon deployment, reperfusion rate after retrieval, thromboembolic events, complications were assessed. histologic structure renal arteries passage measured to further assess JRecan. Results Immediate achieved...