A5103038966- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Intracranial Aneurysms: Treatment and Complications
- Diabetes and associated disorders
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Telomeres, Telomerase, and Senescence
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Diet and metabolism studies
- Hepatitis C virus research
- Dietary Effects on Health
- Healthcare and Venom Research
- Cholinesterase and Neurodegenerative Diseases
- Medication Adherence and Compliance
- Cardiovascular Disease and Adiposity
- Plant Virus Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Genetics, Aging, and Longevity in Model Organisms
- Biochemical effects in animals
Huazhong University of Science and Technology
2019-2025
Tongji Hospital
2019-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Institute of Crop Sciences
2024
Chinese Academy of Agricultural Sciences
2024
Heilongjiang Provincial Academy of Agricultural Sciences
2024
Yunnan Agricultural University
2023
Institute of Apiculture Research
2023
Shanghai Jiao Tong University
2012
Shanghai Sixth People's Hospital
2012
Objective This study explores the clinical characteristics of patients with diabetes severe covid-19, and association survival duration in covid-19. Research design methods In this single-center, retrospective, observational study, laboratory 193 covid-19 were collected. 48 had diabetes, 145 (ie, controls) did not have diabetes. A case was defined as including at least one following criteria: (1) Respiratory rate >30/min. (2) Oxygen saturation ≤93%. (3) PaO 2 /FiO ≤300 mm Hg. (4)...
Abstract Background The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. This study aims to evaluate the association TyG with severity mortality coronavirus disease 2019 (COVID-19). Methods included cohort 151 patients COVID-19 admitted in tertiary teaching hospital Wuhan. Regression models were used investigate between COVID-19. Results In this cohort, 39 (25.8%) had diabetes, 62 (41.1%) severe cases, while 33 (22.0%) died hospital. levels...
<b>Objective: </b> To test whether symptomatic severe intracranial atherosclerotic stenosis was associated with a higher subsequent stroke risk than moderate after elective angioplasty balloon-expandable stent and to explore which factors were the stroke. <b>Methods: Between September 2001 June 2005, there 220 stenoses in 213 patients undergoing stenting at our institute. Of these stenoses, 126 121 ≥70% 94 92 50% 69% stenoses. Primary endpoints included lesion-related ischemic stroke, brain...
AimsThis study assessed factors contributing to glycemic control among diabetes mellitus patients complying with home quarantine during the epidemic of coronavirus disease 2019 (COVID-19).MethodsWe conducted an analytical cross-sectional by telephone 1159 type 2 (T2DM) and 96 1 (T1DM) who were discharged from endocrinology department a hospital January 1, 2019, 24, 2020. According their fasting blood glucose (FBG) 2-h postprandial BG (2hPBG) values, divided into well-controlled group poorly...
Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying development cognitive dysfunction in individuals with T2DM remain elusive. Herein, we discussed role Bmal1, core circadian rhythm-regulating gene, process T2DM-associated dysfunction. We identified marked decrease BMAL1 levels hippocampus db/db mice, followed by gain- and loss-of-function studies to explore impact on function. Our findings indicated that downregulation...
Rheumatoid arthritis (RA) is a type of difficult-to-cure arthralgia with worldwide prevalence. It severely affects people's living standards. For long time, bee venom has been used to treat RA and shown good results. Melittin the main active component for treatment, but molecular mechanism melittin in treatments remains unclear.Potential targets were obtained from relevant databases, common screened. The STRING database was build PPI network screen core after visualization. enriched by Gene...
Seventy-nine consecutive patients with symptomatic atherosclerotic stenosis ≥ 50% of intracranial vertebrobasilar artery (VBA) were treated by elective stenting. There five strokes within 30 days, and three in the VBA territory after days (mean 812 days). The annual stroke rate (including any death days) was 4.6%. At last follow-up time, 73 independent (modified Rankin scale grade ≤ 2). outcome compares favorably medical therapy.
This study aimed to compare HOMA-IR, leptin, and resistin as the risk factors for diabetic nephropathy in type 2 diabetes mellitus (T2DM) patients with different BMI classifications.A total of 309 T2DM were enrolled this cross-sectional study. All participants divided into three groups according BMI: normal weight group (18.5 kg/m2≤BMI<24 kg/m2), overweight (24kg/m2≤BMI<28 kg/m2) obesity (BMI≥28 kg/m2). The clinical information laboratory examinations recorded detail. Leptin levels measured...
A novel classification has been introduced to promote precision medicine in diabetes. The current study aimed investigate the relationship between leptin and resistin levels with refined subgroups patients type 2 diabetes mellitus (T2DM).The k-means analysis was conducted cluster 541 T2DM into following four subgroups: mild obesity-related (MOD), severe insulin-deficient (SIDD), insulin-resistant (SIRD) age-related (MARD). Individuals meeting exclusion criteria were eliminated, data for 285...
APPL1 and APPL2 are two adaptor proteins, which can mediate adiponectin signaling via binding to N terminus of receptors in muscle cells. Genes encoding contribute insulin resistance the risk obesity, genetic variants associated with body fat distribution. However, association between variations metabolic traits remains unknown. In current study, we aimed test impacts on obesity a Chinese population normal glucose tolerance. We genotyped six single nucleotide polymorphisms (SNPs) 1,808...
Telomere length has been linked to hepatic fibrosis. Type 2 diabetes mellitus (T2DM) is considered as a particular risk for the development of This study explore association leucocyte telomere (LTL) and nonalcoholic fatty liver disease (NAFLD)-related advanced fibrosis in T2DM patients.A total 442 patients with were enrolled from Tongji Hospital, Wuhan, China. Clinical features collected LTL was measured by Southern blot-based terminal restriction fragment length. Hepatic determined both...
Background and Objective: Type 2 Diabetes (T2D) patients are more prone to develop Alzheimer’s Disease (AD). We have previously shown that Glucagon-like peptide-1 receptor agonist exendin-4 (Ex-4) reduces tau hyperphosphorylation in T2D animals through upregulating insulin signaling, peripheral injected Ex-4 increases levels the brain. This study aims further clarify whether elevated brain is produced by nerve cells under action of Ex-4. Methods: The neuronal cell line-HT22 was treated with...
Abstract Background: Leukocyte telomere has been shown to be related insulin resistance-related diseases, such as type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). This cross-sectional study investigated the association of leukocyte length (LTL) with NAFLD in T2DM patients. Methods: Clinical features were collected LTL was measured by Southern blot-based terminal restriction fragment analysis 120 patients without age-matched NAFLD. clinically defined...
<b><i>Aims:</i></b> This study aimed to explore the new role of telomere length (TL) in novel classification type 2 diabetes mellitus (T2DM) patients driven by cluster analysis. <b><i>Materials and Methods:</i></b> A total 541 T2DM were divided into 4 subgroups <i>k</i>-means analysis: mild obesity-related (MOD), severe insulin-deficient (SIDD), insulin-resistant (SIRD), age-related (MARD). After with insufficient data excluded,...