A5111831050- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bladder and Urothelial Cancer Treatments
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Reconstructive Facial Surgery Techniques
- Diabetes Treatment and Management
- Reconstructive Surgery and Microvascular Techniques
- Peroxisome Proliferator-Activated Receptors
- Diabetes Management and Research
- Cholesterol and Lipid Metabolism
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
Sun Yat-sen University
2024-2025
Shanghai Jiao Tong University
2015-2024
Shanghai Sixth People's Hospital
2015-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Gansu Provincial Hospital of TCM
2024
Tianjin University
2024
Tianjin Chest Hospital
2024
Creative Commons
2023
Shanghai Ninth People's Hospital
2015-2023
Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt analyze independent and joint effect of variants from these on clinical phenotypes related glucose metabolism.Twenty-one single nucleotide polymorphisms (SNPs) fourteen were successfully genotyped 1,849 subjects with 1,785 normal regulation. We analyzed allele genotype distribution between cases controls SNPs as well effects risk. The associations examined by...
The present study attempted to evaluate the mechanism of action and bioactivity mulberry leaf polyphenols (MLPs) in type-2 diabetes prevention<italic>via</italic>inhibition disaccharidase glucose transport.
Backgrounds Chronic stress could induce depression-like phenotype in animal models. Previous data showed that sex differences exist after chronic model establishment, however, the detailed information about difference of blood biochemical indexes is not clear. In this study, we aim to supply comparison monoamine transmitters and related hormone markers serum between male female depressed mice, order better understand levels depression occurrence development. Methods Sixty C57BL/6 mice (both...
Background Although the systemic administration of deferoxamine (DFO) is protective in experimental models normal ischemic flap and diabetic wound, its effect on ischemia using a local injection remains unknown. Objective To explore feasibility DFO to improve survival random skin flaps streptozotocin (STZ)-induced mice. Methods Ischemic were made 125 Animals divided into DFO-treated (n = 20), PBS-treated 16) untreated groups. Surviving area, vessel density, expression vascular endothelial...
Abstract Background Stress hyperglycemia ratio (SHR) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are independently associated with increased mortality risk in diabetic patients coronary artery disease (CAD). However, the role of these biomarkers diabetes multivessel (MVD) remains unknown. The present study aimed to assess relative combined abilities predict all-cause MVD. Methods This included 1148 MVD who underwent angiography at Tianjin Chest Hospital between January 2016...
Background: Stem cell-like properties are known to promote the recurrence and metastasis of hepatocellular carcinoma (HCC), contributing a poor prognosis for HCC patients. Betaine, an important phytochemical methyl-donor related substance, has shown protective effects against liver diseases. However, its effect on stem underlying mechanisms remains uninvestigated. Methods: We measured betaine malignant progression using patient-derived xenografts, cell-derived tail vein-lung models, in vitro...
Obesity results in an increased risk of metabolic syndrome (MetS) and Type 2 diabetes (T2DM). Body fat percentage (BF%) is a common index body composition. The aim the present study was to determine optimal BF% cut-offs for obesity predict MetS T2DM Chinese adults. baseline group comprised 3916 adults (age 30-70 years age); 2033 subjects without or were followed up maximum 5.5 years. estimated using bioelectrical impedance analysis. Optimal analysed by receiver operating characteristic (ROC)...
Evidence regarding the individual and combined impact of dietary flavonoids on risk metabolic dysfunction associated with steatotic liver disease (MASLD) remains scarce. Our objective is to evaluate association between multiple MASLD in adults. Data sets were obtained from National Health Nutrition Examination Survey (NHANES), 2017-2018. In total, 2581 participants aged over 18 years, complete information flavonoid intake, MASLD, covariates, included. Flavonoid intake was energy-adjusted...
Background Hypertrophic scars are pathologic proliferations of the dermal skin layer resulting from excessive collagen deposition during healing process cutaneous wounds. Current research suggests that TGF-β/Smad signaling pathway is closely associated with normal scar and hypertrophic formation. TRAP-1-like protein (TLP), a cytoplasmic protein, has been reported to efficiently regulate Smad2- Smad3-dependent signal expression in TGF-β pathway. The relationship between TLP Type I/III (Col...
Pancreatic β-cells are the major extraneural site of glutamate decarboxylase expression (GAD). During culture isolated β-cells, GAD product γ-aminobutyrate (GABA) is rapidly released in medium, independently insulin. It considered as a possible mediator β-cell influences on α-cells, acinar cells, and/or infiltrating lymphocytes. In this perspective, we investigated regulation GABA release by rat during 24-h period. Glucose was previously reported to inhibit diverting cellular mitochondrial...