A5100388054- Epilepsy research and treatment
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Pharmacological Effects and Toxicity Studies
- Brain Tumor Detection and Classification
- Eosinophilic Esophagitis
- Neonatal and fetal brain pathology
- Dermatology and Skin Diseases
- Child Nutrition and Feeding Issues
- Neuropeptides and Animal Physiology
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Schizophrenia research and treatment
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Pituitary Gland Disorders and Treatments
- Pharmaceutical studies and practices
- Glaucoma and retinal disorders
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Cancer, Lipids, and Metabolism
Children's Hospital of Fudan University
2020-2024
Sunovion (United States)
2021-2023
Vion Pharmaceuticals (United States)
2021-2023
Sunovion (United Kingdom)
2023
Dali University
2023
Tibet University
2022
Air Force Medical University
2019
Second Affiliated Hospital of Dalian Medical University
2012
Karolinska Institutet
2009-2012
Dalian Medical University
2012
Background Visual assessment rating scales for medial temporal lobe (MTL) atrophy have been used by neuroradiologists in clinical practice to aid the diagnosis of Alzheimer's disease (AD). Recently multivariate classification methods magnetic resonance imaging (MRI) data suggested as alternative tools. If computerized are be implemented they need good as, or better than experienced and carefully validated. The aims this study were: (1) To compare ability MTL visual scales, a MRI method...
Animal studies and clinical observations suggest that epilepsy is associated with inflammation. Translocator protein (TSPO) (18 kDa), a marker of inflammation, increased in vitro surgical samples from patients temporal lobe epilepsy. TSPO can be measured the living human brain PET novel radioligand (11)C-PBR28. In this study, we sought to determine whether vivo expression ipsilateral seizure focus epilepsy.Sixteen unilateral 30 healthy subjects were studied (11)C-PBR28 MRI. Uptake...
BACKGROUND AND OBJECTIVES: Aimed to investigate the safety, accuracy, and efficacy of stereo electroencephalography (SEEG) in children various ages, with particular emphasis on those younger than 3 years. There is limited guidance regarding whether SEEG can conducted very young children. METHODS: This retrospective study was between July 2018 August 2022. It involved 88 patients who underwent 99 robot-assisted procedures at our center. The were categorized into groups based their age time...
It is important to have a replicable easy method for monitoring atrophy progression in Alzheimer's disease. Volumetric methods calculating hippocampal volume are time-consuming and commonly used research. Visual assessments of medial temporal lobe (vaMTA) rapid clinical use. This has not been tested large non-demented population comparison with volumetry measurements. Since decreases time even normal aging there also need study the age differences atrophy.To compare visual assessment...
Background: Nausea is common upon initiating dopamine agonists in patients with Parkinson’s disease (PD); however, pretreatment an antiemetic recommended only when apomorphine formulations. Objective: Evaluate the need for prophylactic use during dose optimization of sublingual film (SL-APO). Methods: A post hoc analysis a Phase III study evaluated nausea and vomiting treatment-emergent adverse events PD who underwent SL-APO (10–35 mg; 5-mg increments) to achieve tolerable FULL ON....
We report outcomes from an open-label, non-randomized, 24-week study of eslicarbazepine acetate (ESL) in adults at earlier and later stages their treatment history for focal seizures, conducted a real-world clinical setting.ESL was taken as the first adjunctive therapy to levetiracetam (LEV) or lamotrigine (LTG) monotherapy (Arm 1), treatment-resistant patients 2). The primary objective evaluate effectiveness ESL (by retention rates). Secondary objectives were efficacy (seizure frequency),...
Perineural invasion (PNI) is reported to correlate with local recurrence and poor prognosis of salivary adenoid cystic carcinoma (SACC). However, the pathogenesis PNI remains unclear. The aims this study were investigate correlation between sympathetic innervation SACC elucidate how neurotransmitter norepinephrine (NE) regulates process.Sympathetic β2-adrenergic receptor (β2-AR) expression in tissues evaluated by immunohistochemistry. NE concentrations dorsal root ganglia (DRG) coculture...
To determine sex differences in the prevalence of depression and assess risk factors for among adult patients with epilepsy from Dali area China.We retrospectively analyzed clinical data who visited First Affiliated Hospital University January 2017 to 2022. Patient Health Questionnaire-9 was used depressive symptoms epilepsy. The were by binary logistic regression different epilepsy.There significant (p < 0.001), females 4.27 times more likely suffer than males (95% confidence interval:...
Background: Giant hypothalamic hamartomas (HHs) are extremely rare lesions, for which the treatment is challenging. While minimally invasive treatments such as radiofrequency thermal coagulation and laser ablation have improved seizure outcomes, multiple operations often required. This study investigated value of one-stage stereo-array thermocoagulation based on stereotactic electroencephalography (SEEG) pediatric giant HHs. Methods: We analyzed clinical data six patients with HHs (masses a...
Abstract Objective Eslicarbazepine acetate (ESL) is a once‐daily (QD), oral anti‐seizure medication for the treatment of focal (partial‐onset) seizures. Here, we evaluate risk factors development psychiatric treatment‐emergent adverse events (TEAEs) in clinical trials adjunctive ESL adults with Methods This post‐hoc analysis evaluated data pooled from three Phase III, randomized, double‐blind, placebo‐controlled (BIA‐2093‐301, ‐302, ‐304). After an 8‐week baseline period, patients were...
Previous studies have investigated the use of hippocampal volumes for diagnosis in Alzheimer's disease. Combinations multiple regional and cortical thicknesses may provide better discrimination between AD, MCI controls however. To compare alone to a combination volumes, thickness measures discriminating patients with disease, subjects mild cognitive impairment healthy age-matched controls. A total 345 were included study (117 118 110 Controls). High resolution sagital MR images compatible...
<h3>Objective:</h3> Here we report the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) in patients who experienced baseline focal to bilateral tonic-clonic seizures (FBTCS). <h3>Background:</h3> ESL is approved for seizure treatment. FBTCS are most severe form place at increased risk injuries sudden unexpected death. <h3>Design/Methods:</h3> Pooled data from 3 randomized clinical trials with (N=1447) were analyzed. After an 8-week baseline, titrated over 2 weeks their...
<h3>Objective:</h3> Data from a post-hoc pooled analysis was used to describe changes in health-related quality of life (HRQOL) measures during treatment with eslicarbazepine acetate (ESL). <h3>Background:</h3> ESL is approved for the focal seizures. HRQOL may be improved by controlling <h3>Design/Methods:</h3> 3 randomized clinical trials were this analysis. After completing double-blind portion, patients eligible enter 1-year open-label extension (OLE), which began immediately after...
Alzheimer's disease (AD) is one of the most common forms neurodegenerative disorders connected with gradual loss cognitive functions such as episodic memory. We used multivariate data analysis, more specifically orthogonal partial least squares to latent structures (OPLS) , discriminate between subjects AD, mild impairment (MCI) and elderly control (CTL) using global regional MRI volumetric measures. 117 AD patients (mean (sd) age = 75(6) years, MMSE 21(5)), 122 MCI (74(6) 27(3)) 112 CTL...