A5046933385- Cerebrovascular and Carotid Artery Diseases
- Magnesium Alloys: Properties and Applications
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Peripheral Artery Disease Management
- Metal and Thin Film Mechanics
- Chemotherapy-induced cardiotoxicity and mitigation
- Corrosion Behavior and Inhibition
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Atherosclerosis and Cardiovascular Diseases
- Aluminum Alloys Composites Properties
- Angiogenesis and VEGF in Cancer
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Vascular anomalies and interventions
- Single-cell and spatial transcriptomics
- Inflammasome and immune disorders
- Lung Cancer Diagnosis and Treatment
Huashan Hospital
2016-2025
Fudan University
2016-2025
Songshan Lake Materials Laboratory
2025
Johnson & Johnson (Singapore)
2024
Shanxi University of Traditional Chinese Medicine
2023
Guangzhou Medical University
2021
Lanzhou University
2017-2021
Xian Yang Central Hospital
2017-2021
Lanzhou University Second Hospital
2017-2021
Tan Tock Seng Hospital
2008
As a member of Sirtuins family, SIRT6 participates in the physiological and pathological progress DNA repair, anti-aging, metabolism, so on. Several studies have demonstrated that knockdown inhibited development atherosclerosis (AS), indicated as protective factor for AS. However, we confirmed was significantly overexpressed human unstable carotid plaques compared with stable plaques. This result more complex role Furthermore, constructed mice model plaque injected them adeno-associated...
Distinctively directing endothelial cells (ECs) and smooth muscle (SMCs), potentially by surface topography cue, is of central importance for enhancing bioefficacy vascular implants. For the first time, gradients with a broad range nano-micrometer roughness are developed on Mg, promising next-generation biodegradable metal, to carry out systematic study response ECs SMCs. Cell adhesion, spreading, proliferation quantified along high-throughput imaging, illustrating drastic divergence between...
Abstract Biodegradable magnesium‐based scaffolds present outstanding potential to revolutionize the treatment of coronary artery diseases, in which full recovery arteries without long‐term irritation implants is anticipated for averting adverse events associated with permanent stents. However, overfast degradation magnesium (Mg) alloys obstructs their extensive applications terms early structural failure and impaired biocompatibility. Herein, a facile copper‐incorporated coating system...
Abstract Ferroptosis has been confirmed to be associated with various diseases, but the relationship between ferroptosis and atherosclerosis (AS) remains unclear. Our research detailly clarified roles of in three continuous main pathological stages AS respectively (injury endothelial cells [ECs], adhesion monocytes, formation foam cells). We that oxidized low‐density lipoprotein (ox‐LDL), key factor pathogenesis AS, strongly induced ECs. Inhibition repressed monocytes ECs by inhibiting...
Nanoscale precipitations in deformed dilute alloying Mg-Zn-RE alloys usually play critical positive roles mechanical properties, while characterizing them still poses a significant challenge due to their small size and low volume fraction. Here, we conduct systematic structural analysis of the nanoscale secondary phase particles, including W phase, amount I handful Mg3Gd hot Mg-Zn-Gd alloy by combining atomic-resolution transmission electron microscopy with first-principles calculations. The...
Cerebral ischemia-reperfusion injury (CIRI) leads to cognitive dysfunction, neuronal death, and inflammation. Understanding the molecular mechanisms underlying CIRI is crucial for developing effective therapeutic strategies. This study aims investigate roles of activating transcription factor 3 (Atf3) lon protease homolog 1 (Lonp1) in CIRI, particularly focusing on how Atf3 regulates Lonp1 expression its effects mitochondrial function. Single-cell transcriptomics proteomic analyses were...
CCL2 was up-regulated in neurons and involved microglia activation neurological decline mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived on vitro. The rats were pretreated with receptor inhibitors (INCB or C021, 1 mg/kg/day i.p.) for 3 days prior to thioacetamide (TAA) administration (300 inducing HE model. At 8 h following last injection (and every 4 after), grade assessed. Blood whole brains collected at coma measuring Iba1...
Biodegradable magnesium alloy stents exhibit deficient corrosion period for clinic applications, making the protective polymer coating more crucial than drug-eluting with permanent metal scaffold. We implemented a cohesive method based on finite element analysis to predict integrity of adhesive between and stent during crimping deployment. For first time, three-dimensional quantitative modeling reveals process delamination stress concentration. The fracture microcracks coatings were...
Peripheral administration of blockers the renin-angiotensin system (RAS) may affect RAS in brain to a variable degree. In present study, we determined inhibition angiotensin-converting enzyme (ACE) after peripheral lipophilic (trandolapril) versus hydrophilic (lisinopril) ACE inhibitor. Trandolapril (0.2, 1, and 5 mg/kg/day, subcutaneously) was compared with lisinopril (2, 10, 50 subcutaneously), each for 6 days. At 4 24 h last dose, 125I-351A binding on measured. caused similar ligand...
Transcarotid artery revascularization (TCAR) is thought to be a promising technique and instrument for treating carotid stenosis with favorable outcomes. Since there remain several differences in anatomic characteristics among races, this study was conducted investigate the eligibility of TCAR Chinese patients who underwent revascularization.A retrospective review from 2019 2021 conducted. The based on instruction ENROUTE Neuroprotection System. configuration circle Willis (CoW) were...
Carotid atherosclerosis is a chronic inflammatory disorder and responsible for the vast majority of ischemic strokes. Inappropriate innate adaptive immune responses synergize with malfunctional vascular wall cells to cause atherosclerotic lesions. Yet, functional characteristics specific endothelial cell subsets associated cerebrovascular events are poorly understood.
Rab5a, a key member of the Rab family GTPases, was determined to be regulator vascular smooth muscle cell (VSMC) proliferation and migration. However, exact regulatory mechanism remains unclear. As Rab5a has been shown associated with autophagy, which is essential for conversion VSMCs from contractile synthetic phenotype in order prevent death due oxidative stress. The present study hypothesized that autophagy may responsible migration via protein. aim evaluate effect on VSMCs. human aorta...
Next-Generation Biodegradable Vascular Stents In article number 2205634, Jia Pei, Guang-Yin Yuan, Jin-Yun Tan and co-workers report a copper-incorporated, catechol-based coating system on biodegradable magnesium-alloy vascular stents to achieve reinforced stent structural durability, meanwhile, allowing for controlled local release of Mg(II) Cu(II) trigger synergistic bioeffect rapid re-endothelialization alleviated neointima hyperplasia, bringing one step closer the deployment...