A5103233563- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- T-cell and B-cell Immunology
- Alzheimer's disease research and treatments
- Hydrogels: synthesis, properties, applications
- Advanced Materials and Mechanics
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Nerve injury and regeneration
- Polymer Surface Interaction Studies
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Renal Transplantation Outcomes and Treatments
Sixth Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Lu'an First People's Hospital
2024
Xuzhou Medical College
2016-2022
Zhejiang Chinese Medical University
2022
Sun Yat-sen University
2019-2021
China Atomic Energy Authority
2021
Fujian Medical University
2017-2021
Sun Yat-sen Memorial Hospital
2019-2021
First Affiliated Hospital of Fujian Medical University
2017-2021
In this study, a series of chitosan films with different protonation degrees were prepared by deacidification NaOH aqueous or ethanol solutions. The then used as model to investigate the effects positive charge on blood coagulation. results showed that acted double-edged sword, in it promoted erythrocyte adhesion, fibrinogen adsorption, and platelet adhesion activation, but inhibited activation contact system. contrast prevailing views, we found retarded thrombin generation coagulation these...
Abstract Metastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our previous proteomics analysis identified DJ-1 as potential metastasis biomarker CRC. In this study, we found that was upregulated in The levels were closely correlated with depths invasion and predicted patient outcome. Enforced expression could enhance CRC proliferation vitro vivo by stimulating Wnt-β-catenin signaling. Specifically, DJ-1-induced β-catenin nuclear translocation stimulated TCF...
Abstract In this study, a novel method was developed to create porous tubular scaffolds with desirable mechanical properties and controllable inner structure from chitosan, for nerve tissue engineering. Chitosan fiber‐based yarns were first used hollow tubes, which served as the outer wall of scaffolds, through an industrial knitting process. Then, innovative molding technique produce matrices multiple axially oriented macrochannels radially interconnected micropores. Acupuncture needles...
Abstract Multimicrotubule chitosan conduits (M‐conduits) were fabricated using novel molds and a thermal‐induced phase‐separation technique. Hollow (H‐conduits) with an inner diameter of 1–5 mm wall thickness 0.2–1.0 made, then mold composed styrofoam insulating pedestal several holes stainless steel cover plate was used to make M‐conduits. In brief, corresponding H‐conduits inserted upright into the pedestal, filled solution, rapidly covered precooled plate, placed in freezer. The enclosing...
Bone morphogenetic proteins (BMPs) have been used to promote bone formation in many clinical scenarios. However, the BMPs are inherently unstable vivo and therefore need be combined with carriers for controlled delivery. In this study, an innovative efficient fibrin glue/fibronectin/heparin (FG/Fn/Hep)-based delivery system was developed release of BMP2. The incorporation heparin can significantly slow BMP2 without substantially affecting structure stiffness FG/Fn. from FG/Fn/Hep-BMP2...
Abstract ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the transcriptional regulatory mechanism of gene its potential role in regulation autophagy remain unknown. In this study, we have for first time identified human promoter, found that transcription directly regulated by p53 implicated induction well apoptosis. A series luciferase reporter assay demonstrated major promoter...
Meniscus plays an important role in joint homeostasis. Tear or degeneration of meniscus might facilitate the process knee osteoarthritis (OA). Hence, to investigate transcriptome change during degeneration, we reveal alterations messenger RNA (mRNA), microRNA (miRNA), long noncoding (lncRNA), and circular (circRNA) OA by whole-transcriptome sequence. A total 375 mRNAs, 15 miRNAs, 56 lncRNAs, 90 circRNAs were significantly altered degenerative treated with interleukin-1β (IL-1β). More...
Liver kinase B (LKB) 1 acts as a tumor suppressor in broad spectrum of human cancers, and is important chemoradiotherapy treatment various types. However, the potential function LKB1 esophageal cancer radiotherapy remains to be elucidated. The aim present study was investigate role radiosensitivity vivo vitro, explore its molecular mechanism. Eca‑109 cells transfected with overexpression plasmid were xenografted into nude mice subjected irradiation it observed that volume significantly...
Objective Thoracoscopy has gained extensive utilization in managing pleural disorders, and enhanced recovery after surgery (ERAS) can improve patients’ prognosis expedite post-surgical recovery. This study aimed to investigate the knowledge, attitudes, practices (KAP) towards ERAS among patients underwent thoracoscopy surgery. Methods cross-sectional was conducted between September 2022 August 2023, 6 Secondary or Tertiary hospitals author’s area. Demographic characteristics KAP scores were...
Chitosan has been widely used for biomaterial scaffolds in tissue engineering because of its good mechanical properties and cytocompatibility. However, the poor blood compatibility chitosan greatly limited biomedical utilization, especially contacting engineering. In this study, we exploited a polymer blending procedure to heparinize material under simple mild conditions improve antithrombogenic property. By an optimized procedure, macroscopically homogeneous chitosan-heparin (Chi-Hep)...
Cervical cancer is a female with the second highest motility over world. It urgent to find new therapeutic methods based on long-coding RNAs and microRNAs. UCA1 was proved be related many human types, but limited researches have been performed for inner associations between cervical cancer. Eighty females who were undergoing surgeries recruited study in our research. We took tissues cells from them. Massive experiments analysis conducted investigate gene expressions protein about UCA1,...
Abstract Background Long noncoding RNAs (lncRNAs) are reported to play important roles in tumorigenesis of various malignant tumors. However, the clinical significance aberrant lncRNA expression hepatocellular carcinoma (HCC) is still elusive. Methods Firstly, a differentially expressed CTC‐297N7.9 HCC was detected by analyzing data from The Cancer Genome Atlas (TCGA). Secondly, level examined four cell lines and 60 pairs tissues polymerase chain reaction (PCR) assay at our center. Thirdly,...
Chitosan/heparin microspheres were prepared using the water-in-oil emulsification solvent evaporation technique. The microsphere diameters controlled by selecting fabrication process parameters. Scanning electron micrographs showed that chitosan/heparin regular and surface morphology was smooth. Fourier transform infrared chitosan amino groups reacted with heparin carboxylic to form acylamides in microspheres. Analysis of cytotoxicity they had no cytotoxic effect behaved very similar...
Rab5a, a key member of the Rab family GTPases, was determined to be regulator vascular smooth muscle cell (VSMC) proliferation and migration. However, exact regulatory mechanism remains unclear. As Rab5a has been shown associated with autophagy, which is essential for conversion VSMCs from contractile synthetic phenotype in order prevent death due oxidative stress. The present study hypothesized that autophagy may responsible migration via protein. aim evaluate effect on VSMCs. human aorta...
Phillyrin (PHN), one of the major active constituents Forsythia suspensa and F. koreana, has been reported to produce antioxidant, antibacterial, anti-obesity anti-inflammatory effects. However, no study demonstrated role PHN in laryngeal squamous cell carcinoma (LSCC). We aimed investigate effects on proliferation apoptosis HEp-2 cells. In present study, alone showed little effect apoptosis. Subsequent tests that could largely enhance level autophagy Combining use blockers including...