A5101556289- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Indoor and Outdoor Localization Technologies
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Facial Rejuvenation and Surgery Techniques
- Cholinesterase and Neurodegenerative Diseases
- Atherosclerosis and Cardiovascular Diseases
- Occupational and environmental lung diseases
- Diet, Metabolism, and Disease
- Infrared Thermography in Medicine
- Galectins and Cancer Biology
- Toxoplasma gondii Research Studies
- Medicinal Plants and Neuroprotection
- Cellular transport and secretion
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- Sphingolipid Metabolism and Signaling
Peking University Shenzhen Hospital
2017-2025
Nanchang University
2019-2023
Ningxia Medical University
2023
Pudong Medical Center
2014-2021
Fudan University
2005-2021
Jinzhou Medical University
2021
Hubei Provincial Center for Disease Control and Prevention
2020
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
Hong Kong University of Science and Technology
2017
Lenalidomide, an immunomodulatory agent that enhances antibody-dependent cellular cytotoxicity (ADCC), is currently being investigated as a therapy for chronic lymphocytic leukemia (CLL). The anti-CD20 antibody rituximab active in CLL and represents rational to combine with lenalidomide. We therefore examined whether lenalidomide combined direct apoptosis ADCC cells. In contrast previous reports using CD20-positive lymphoma cell lines, down-regulated CD20 surface antigen expression patient...
Lung adenocarcinoma (LUAD) is the most common type of lung cancer. Tripartite motif 13 (TRIM13) a member TRIM protein family and downregulated in multiple cancers, especially non-small cell cancers (NSCLC). In this study, we investigated anti-tumor mechanism TRIM13 cancer tissues lines. First, mRNA levels LUAD tissue cells were measured. was overexpressed on to investigate effects proliferation, apoptosis, oxidative stress, p62 ubiquitination, autophagy activation. Finally, mechanistic role...
Submental fat (SMF) is a common aesthetic concern traditionally treated with liposuction. Non-surgical alternatives like injectable deoxycholic acid are gaining popularity. However, no related products have been clinically approved in China. This study evaluated the efficacy and safety of MEI005, acid-based formulation, reducing SMF Chinese adults. multicenter, randomized, double-blind, placebo-controlled phase III trial included 325 adults moderate to SMF. Participants received MEI005 or...
Nonalcoholic fatty liver disease (NAFLD) is a common chronic with many influencing factors. With the increasing role of gut-liver axis in various diseases, research on prevention and treatment NAFLD probiotics increasing. In present study, Bifidobacterium animalis subsp. strain, B. lactis SF, was isolated from feces healthy infants characterized by sequencing 16S rDNA. A systematic probiotic evaluation carried out, diet-induced mouse model constructed to study effect mechanism SF NAFLD....
ABSTRACT Melioidosis, caused by Burkholderia pseudomallei , is considered to be endemic Northern Australia and Southeast Asia, with high mortality relapse rates, regardless of powerful antibiotic therapy. Here we report the first genome sequence strain BPC006, obtained from a melioidosis patient in Hainan, China. The sizes 2 chromosomes were determined 4,001,777 bp 3,153,284 bp.
Abstract Purpose: To date, efforts to study CD52-targeted therapies, such as alemtuzumab, have been limited due the lack of stable CD52 expressing transformed B-cell lines and animal models. We describe generation utilization cell that stably express both in vitro vivo. Experimental Design: By limiting dilution, we established several clones Raji-Burkitt's lymphoma line surface CD52. Immunophenotype cytogenetic characterization these was done. In vivo usefulness CD52high evaluate therapeutic...
Summary Hyaluronic acid ( HA ) is now extensively employed for esthetic concerns. In the majority of cases, considered to be safe, but mild‐to‐severe complications can occur in a few cases. Hyaluronidase enzymes that degrade , also being suggested treatment filler‐induced complications. However, hyaluronidase has been reported potential cause allergic responses some anesthetic and ophthalmic literature. there are reports reactions cosmetic medicine. We herein report on 39‐year‐old Asian...
Rab5a, a key member of the Rab family GTPases, was determined to be regulator vascular smooth muscle cell (VSMC) proliferation and migration. However, exact regulatory mechanism remains unclear. As Rab5a has been shown associated with autophagy, which is essential for conversion VSMCs from contractile synthetic phenotype in order prevent death due oxidative stress. The present study hypothesized that autophagy may responsible migration via protein. aim evaluate effect on VSMCs. human aorta...
Salvianolic acid A (SalA) has been shown to confer robust protection against endothelial injury. VLDL receptor is expressed at high levels on the surface, however its biological effect cells not yet completely elucidated. Here, we investigated molecular effects of SalA expression and barrier dysfunction under conditions ischemia/reperfusion (IS/RP).Human umbilical vein (HUVECs) treated with were subjected IS/RP stimulation. Endothelial permeability, ZO-1 distribution, actin cytoskeleton...
Pancreatic cancer (PC) is a common malignancy with poorly understood pathogenesis. Currently, the efficacy of anti‑PC therapies insufficient, partially due to chemoresistance cells. The present study aimed elucidate role miR‑183 in proliferation, apoptosis, and chemosensitivity 5‑fluorouracil gemcitabine human PC cells associated mechanisms. PANC‑1 were transfected microRNA (miR)‑183 inhibitors, effect on cell proliferation was evaluated via MTT assay. Apoptosis cycle distribution determined...
In wireless sensor and actor networks, many applications depend on position information of those sensors sensing the physical world. Many localization schemes have been proposed WSNs or ad hoc, however, due to difference between them WSANs, these may not be well suited for WSANs. this paper, we analyze why existing are adaptive WSANs then present ECLS, a novel design unique features application requirements ECLS is an event-driven method which characterized by such new ideas as limited...
Inhalation of silica particles leads to pulmonary inflammatory responses. Clara cell protein 16 (CC16) has been reported played a protective role in lung diseases. However, its on particles-induced inflammation not fully clarified. In this study, THP-1 macrophages were exposed 75 μg/cm2 with or without 2 μg/mL exogenous CC16 (recombinant CC16, rCC16) for 24 hr. The production cytokines, including interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6, the supernatants different groups...
Atherosclerosis is a chronic process that takes place in the vascular wall and causes various cardiovascular diseases (CVDs). Micro-RNA-149 (miR-149) mediates many physiological pathological processes, including atherosclerosis. However, it unclear about roles of miR-149 endothelial injury. Here, we explored protective effect related mechanism cells induced with oxidized low-density lipoprotein (ox-LDL).Human cell lines (HUVECs) were exposed to ox-LDL induce Cell viability was determined by...
MicroRNAs (miRNAs/miRs) play vital roles in various immune diseases including systemic lupus erythematosus (SLE). The current study aimed to assess the role of miR-145 interleukin-6 (IL-6)-treated HaCaT cells under ultraviolet B (UVB) irradiation and further explore potential regulatory mechanism. were pretreated with IL-6 then exposed UVB effect on sensitivity irradiation. levels MyD88 altered by transfection transfected efficiency was verified quantitative reverse transcription polymerase...