A5029850391- Plant Physiology and Cultivation Studies
- Postharvest Quality and Shelf Life Management
- Cardiac Ischemia and Reperfusion
- Neuropeptides and Animal Physiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Plant Gene Expression Analysis
- Electrospun Nanofibers in Biomedical Applications
- Fiber-reinforced polymer composites
- Plant biochemistry and biosynthesis
- Receptor Mechanisms and Signaling
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Adenosine and Purinergic Signaling
- Craniofacial Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Circadian rhythm and melatonin
- Ubiquitin and proteasome pathways
- Renin-Angiotensin System Studies
- Liver Disease Diagnosis and Treatment
- Fungal Plant Pathogen Control
- Endometriosis Research and Treatment
- Wnt/β-catenin signaling in development and cancer
- Atherosclerosis and Cardiovascular Diseases
- Phytoestrogen effects and research
- Heat shock proteins research
Beijing University of Chemical Technology
2007-2024
Xinjiang Medical University
2023-2024
First Affiliated Hospital of Xinjiang Medical University
2023-2024
Hubei Academy of Agricultural Sciences
2007-2023
Shantou University
2020-2022
First Affiliated Hospital of Shantou University Medical College
2021-2022
Shihezi University
2015-2022
Dongfeng General Hospital
2022
Shantou University Medical College
2020
Shantou Central Hospital
2020
Abstract Surgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting high recurrence rates patients. Herein, a bioactive injectable hydrogel (BG‐Mn gel ) formed by crosslinking sodium alginate (SA) with manganese‐doped glass (BG‐Mn) is developed as versatile platform anti‐tumor immunotherapy postoperative The incorporation of Mn 2+ within (BG) can activate cGAS‐STING immune...
The biodegraded cellulose acetate (CA)/poly-<sc>l</sc>-lactic acid (PLLA)/halloysite nanotube composite nanofiber membranes were fabricated for the preparation of gel polymer electrolytes (GPEs) used in lithium-ion batteries.
Prion diseases are caused by conversion of a normally folded, non-pathogenic isoform the prion protein (PrP(C)) to misfolded, pathogenic (PrP(Sc)). inoculation experiments in mice expressing homologous PrP(C) molecules on different genetic backgrounds displayed incubation times, indicating that reaction may be influenced other gene products. To identify genes contribute pathogenesis, we analysed times prions which product was inactivated, knocked out or overexpressed. We tested 20 candidate...
Previous studies showed that Toll-like receptor 4 (TLR4) modulates the myocardial inflammatory response to ischemia-reperfusion injury, and we recently found cytokines link TLR4 postischemic cardiac dysfunction. Although can be activated in cultured cells by endogenous agents including heat shock protein 70, how it is during unknown. In present study, examined 1) whether cognate 70 (HSC70), which constitutively expressed myocardium, released ischemia-reperfusion; 2) extracellular HSC70...
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disease in females that characterized by hyperandrogenemia, chronic anovulation, and polycystic ovaries. However, the exact etiology pathogenesis of PCOS are still unknown. The aim this study was to clarify bacterial, stress status, metabolic differences gut microbiomes healthy individuals patients with high body mass index (BMI) (PCOS-HB) normal BMI (PCOS-LB), respectively. Here, we compared microbiota characteristics PCOS-HB,...
The antarctic notothenioid fishes avoid freezing through the action of circulating antifreeze glycoproteins (AFGPs). This study investigated whether AFGPs could serve as cryoprotectants for isolated rat heart under three different storage conditions. (1) Hearts were flushed with 15 mg AFGP/ml cardioplegic solution (CP) and stored 9 h at 0 degrees C. AFGP concentration has been reported to protect pig oocytes during hypothermic storage. (2) 10 CP-14 frozen -1.4 C 3 h. At this significantly...
Melatonin is predominately produced and secreted by the pineal gland, inhibits cell growth in various cancer lines such as colorectal cancer. However, precise mechanisms involved have not been fully elucidated. In present study, potential molecular mechanism underlying efficacy of melatonin on migration RKO colon cells was investigated. The effects H‑1152, a selective inhibitor Rho‑associated protein kinase (ROCK), were analyzed an vitro wound healing assay. localization zonula occludens‑1...
Background: Melatonin, which is mainly produced by the pineal gland, has a good inhibitory effect on cell growth of multiple cancer types. However, underlying molecular mechanisms anti-tumor activity for colon have not been fully elucidated. In this study, we investigated effects melatonin migration in human RKO cells and potential mechanisms. Materials Methods: The viability was MTT assay after treatment with melatonin, SB203580 (p38 inhibitor) phorbol 12-myristate 13-acetate (PMA, MAPK...
Abstract Background Flavor contributes to the sensory quality of fruits, including taste and aroma aspects. The foods is related their flavor-associated compounds. Pear fruits have a fruity sense smell, esters are main contributor aroma. Korla pear well known due its unique aroma, but mechanism genes volatile synthesis not been fully investigated. Results Flavor-associated compounds, 18 primary metabolites 144 volatiles, were characterized in maturity ten cultivars from five species,...
Recent studies have shown that inhibition of angiotensin-converting enzyme (ACE) or angiotensin II receptors causes upregulation the B(1) receptor (B(1)R). Here we tested hypothesis activation B(1)R partly contributes to cardiac beneficial effect ACE inhibitor (ACEi) and blockers (ARB). knockout mice (B(1)R(-/-)) C57Bl/6J (wild-type control animals, WT) were subjected myocardial infarction (MI) by ligating left anterior descending coronary artery. Three weeks after MI, each strain was...
Pear black spot (PBS) disease, which is caused by Alternaria alternata (Aa), one of the most serious diseases affecting sand pear (Pyrus pyrifolia Nakai) cultivation worldwide. To investigate defense mechanisms in response to Aa, transcriptome a germplasm with differential resistance Aa was analyzed using Illumina paired-end sequencing. Four libraries derived from PBS-resistant and PBS-susceptible leaves were characterized through inoculation or mock-inoculation. In total, 20.5 Gbp sequence...
All-trans-retinoic acid (ATRA) inhibits the invasive and metastatic potentials of various cancer cells. However, underlying mechanism is unclear. Here, we demonstrate that ATRA inhibited colorectal cells RKO (human colon adenocarcinoma cell) migration by downregulating cell movement increasing adhesion. expression activation myosin light chain kinase (MLCK) in cells, while level MLC phosphatase (MLCP) had no change treated with or without ATRA. The activity was also exposed to Intriguingly,...
To characterize the gut bacteriome, mycobiome and serum metabolome profiles in polycystic ovary syndrome (PCOS) patients with normal/overweight individuals evaluate a potential microbiota-related diagnostic method development for PCOS, 16S rRNA ITS2 gene sequencing using 88 fecal samples 87 analysis from are conducted PCOS classifiers based on multiomics markers constructed. There significant bacterial, fungal community metabolite differences among healthy volunteers individuals. Healthy...
Pear black spot disease, caused by
Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we interrogated AR-regulated proteome identified PDZ binding kinase (PBK) as novel protein that regulates full-length AR variants (ARVs) PrCa. PBK overexpression PrCa associated with early biochemical relapse poor clinical outcome. In addition to its carboxy terminus...