A5100344827- Metabolomics and Mass Spectrometry Studies
- Acute Ischemic Stroke Management
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Advanced Glycation End Products research
- Hearing Loss and Rehabilitation
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- Hormonal Regulation and Hypertension
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Ischemia and Reperfusion
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Thyroid Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cardiomyopathy and Myosin Studies
- Gastrointestinal motility and disorders
- Prostate Cancer Treatment and Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- Evolution and Paleontology Studies
Capital Medical University
2016-2025
Chinese PLA General Hospital
2024-2025
Beijing Anzhen Hospital
2017-2025
Southern Medical University
2021-2025
Beijing Tongren Hospital
2015-2025
Beijing Institute of Water
2015-2025
Nanfang Hospital
2021-2025
Nanjing University of Chinese Medicine
2023-2025
Bohai University
2025
Jiangnan University
2024
Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were significantly associated with poor overall survival of mCRPC patients. In this study, we evaluated if induced chemo-resistance to docetaxel through regulating target genes drug resistance. first compared expression level between tissues normal using data from The Cancer Genome Atlas (TCGA). To...
We aimed to evaluate the efficacy of remote ischemic conditioning (RIC) in patients with cerebral small-vessel disease.Thirty disease-related mild cognitive impairment were enrolled this prospective, randomized controlled study for 1 year. Besides routine medical treatment, participants into experimental group (n=14) undergoing 5 cycles consisting ischemia followed by reperfusion minutes on both upper limbs twice daily year or control (n=16) who treated sham ischemia-reperfusion cycles. The...
Misdiagnosis of acute aortic dissection (AAD) can lead to significant morbidity and death. Soluble ST2 (sST2) is a cardiovascular injury-related biomarker. The extent which sST2 elevated in AAD whether discriminate from other causes sudden-onset severe chest pain are unknown.We measured plasma concentrations (R&D Systems assay) 1360 patients, including 1027 participants the retrospective discovery set 333 patients with initial suspicion enrolled prospective validation cohort. Measures...
Mass spectrometry-based metabolomics has emerged as a powerful technique for biomedical research, although technical issues with its analytical precision and structural characterization remain. Herein, robust non-targeted strategy accurate quantitation precise profiling of metabolomes is developed applied to investigate plasma metabolic features associated human aging. A comprehensive set isotope-labeled standards (ISs) covering major pathways incorporated quantify polar metabolites....
Cuproptosis is a recently recognized modality of cell death driven by intracellular copper-dependent mitochondrial stress. However, the mediators sterile inflammatory response to cuproptotic are undetermined. Here, we report that high-mobility group box 1 (HMGB1), damage-associated molecular pattern, released cells initiate inflammation. Mechanically, copper accumulation-induced adenosine triphosphate (ATP) depletion activates AMP-activated protein kinase (AMPK) promote HMGB1...
Post-stroke cognitive impairment (PSCI) is a common sequela after stroke. China has large population of stroke survivors, but large-scale survey on the incidence and risk factors for PSCI not been undertaken. We aimed to calculate vascular symptoms among first-ever survivors in through multicenter cross-sectional study.From May 1, 2019 November 30, 2019, patients with clinical diagnosis ischemic were recruited from 563 hospitalized-based center networks 30 provinces China. Cognitive was...
Melatonin, an indolamine produced and secreted predominately by the pineal gland, exhibits a variety of physiological functions, possesses antioxidant antitumor properties. But, mechanisms for anti-cancer effects are unknown. The present study explored melatonin on migration human lung adenocarcinoma A549 cells its mechanism.MTT assay was employed to measure viability treated with different concentrations melatonin. effect analyzed wound healing assay. Occludin location observed...
The degeneration of vascular smooth muscle cell(s) (SMC) is one the key features thoracic aortic aneurysm and dissection (TAAD). We others have shown that elevated endoplasmic reticulum (ER) stress causes SMC loss TAAD formation, however, mechanism how dysfunction contributes to intimal damage, leading TAAD, remains be explored. In present study, in vitro assay demonstrated mechanical stretch (18% elongation, 3600 cycles/h) stimulated ER response microparticle(s) (MP) production from both...
Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI) encountered, particularly amongst elderly patients with clinical scenarios, such as age-related arteriosclerotic vascular disease, heart surgery and organ transplantation, is still an unsettled conundrum that besets clinicians.Remote ischemic conditioning (RIC), delivered via transient, repetitive noninvasive IR interventions to distant organs or tissues, regarded innovative approach against IRI.Based on...
Oxidative stress and inflammation play important roles in the development of diabetes mellitus. p-Synephrine, primary pharmacologically active protoalkaloid Citrus species, has been popularly consumed as a dietary supplement for weight loss management. However, effects p-synephrine on mellitus action mechanisms have not clearly elucidated. In this study, vitro antioxidant were evaluated. The data showed that treatment exhibited significant scavenging against DPPH, ABTS OH radicals high...
Importance Recombinant human prourokinase (rhPro-UK) is a thrombolytic agent that has shown promising findings in phase 2 clinical trial patients with acute ischemic stroke (AIS). Objective To evaluate the efficacy and safety of rhPro-UK thrombolysis within 4.5 hours symptom onset AIS. Design, Setting, Participants This randomized, alteplase-controlled, open-label, 3 was conducted from May 2018 to 2020 at 35 medical centers China. A total 684 were screened 674 enrolled. Included aged 18 80...
Abstract Healthy aging leads to complex changes in the functional network of speech processing a noisy environment. The dual‐route neural architecture has been applied study processing. Although evidence suggests that senescent increases activity brain regions across dorsal and ventral stream offset reduced periphery, regulatory mechanism networks underlying such compensation remains largely unknown. Here, by utilizing near‐infrared spectroscopy (fNIRS), we investigated compensatory...
Despite advances in the molecular biology of cardiac myosin binding protein-C (cMyBP-C), little is understood about its precise role muscle contraction, particularly intact heart. We tested hypothesis that cMyBP-C central to time course and magnitude left ventricular systolic elastance (chamber stiffening), assessed mechanisms for this influence hearts, trabeculae, skinned fibers from wild-type (+/+) homozygous truncated (t/t) male mice. protein was not detected by gel electrophoresis or...
Abstract Lung cancer is one of the most common and lethal cancers in world. In this study, a home‐devised hydrophilic interaction chromatography/RPLC‐MS (HILIC/RPLC‐MS) system was developed to study urinary metabonomics lung patients. This combined orthogonal selectivity HILIC RPLC could chromatographically reveal more comprehensive information metabolites. Within total analysis time 50 min, we detected 577 polar metabolite ions on first column 261 apolar ones second column. addition, an...
The goal of this study was the application a novel, fully automatic column-switching approach in metabonomics combining orthogonal selectivities hydrophilic interaction chromatography (HILIC) and reversed-phase chromatography. temporal, pharmacodynamic effects ginsenoside Rg3 on metabonome urine healthy liver-tumor-bearing rats have been investigated. Within total analysis time 52 min we detected 5686 polar, second column an additional 1808 apolar, urinary metabolite ions. administration...
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. To date, molecular mechanisms DN remain largely unclear. The present study aimed to identify and characterize novel proteins involved in development by a proteomic approach. Proteomic analysis revealed that 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase 2 (HMGCS2), key enzyme ketogenesis, was increased fourfold kidneys type diabetic db/db mice. Consistently, activity HMGCS2 24-h urinary excretion ketone body...