A5077782269- Higher Education and Teaching Methods
- Innovative Educational Techniques
- Glioma Diagnosis and Treatment
- Education and Work Dynamics
- Education and Critical Thinking Development
- Innovative Teaching Methods
- Educational Technology and Pedagogy
- Higher Education Learning Practices
- Educational Technology and Assessment
- Engineering Education and Curriculum Development
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Educational Assessment and Pedagogy
- Lung Cancer Research Studies
- Innovative Teaching and Learning Methods
- Library Science and Information Literacy
- EFL/ESL Teaching and Learning
- Atrial Fibrillation Management and Outcomes
- Natural Language Processing Techniques
- Embedded Systems and FPGA Design
- Acute Ischemic Stroke Management
- Speech and dialogue systems
- Dental Health and Care Utilization
- Cancer, Hypoxia, and Metabolism
- Second Language Learning and Teaching
Guangdong 999 Brain Hospital
2021-2025
Henan University
2009-2024
Guizhou University
2024
Nanjing University of Chinese Medicine
2024
Betta Pharmaceuticals (China)
2024
California State University, Chico
2018-2023
Northwest A&F University
2023
Chongqing University
2023
Chongqing Cancer Hospital
2023
Xuzhou Central Hospital
2023
Abstract Background Gut microbiota alterations have been implicated in sepsis and related infectious diseases, but the causal relationship underlying mechanisms remain unclear. Methods We evaluated association between gut composition using two-sample Mendelian randomization (MR) analysis based on published genome-wide study (GWAS) summary statistics. Sensitivity analyses were conducted to validate robustness of results. Reverse MR integration GWAS expression quantitative trait loci (eQTL)...
Toxicogenomic responses in Medicago truncatula A17 were monitored following exposure to biosolids-amended soils. Treatments included biosolids produced using a pilot wastewater treatment plant with either no metal introduced into the influent (control); bulk/ionic TiO2, ZnO, and AgNO3 added (bulk/dissolved treatment); or Ag, TiO2 engineered nanomaterials (ENM treatment) then soil, which was aged field for 6 months. In our companion study, we found inhibition of nodulation ENM but not...
Importance Recombinant human prourokinase (rhPro-UK) is a thrombolytic agent that has shown promising findings in phase 2 clinical trial patients with acute ischemic stroke (AIS). Objective To evaluate the efficacy and safety of rhPro-UK thrombolysis within 4.5 hours symptom onset AIS. Design, Setting, Participants This randomized, alteplase-controlled, open-label, 3 was conducted from May 2018 to 2020 at 35 medical centers China. A total 684 were screened 674 enrolled. Included aged 18 80...
Sepsis-associated encephalopathy (SAE) causes acute and long-term cognitive deficits. However, information on the prevention treatment of dysfunction after sepsis is limited. The neuropeptide orexin-A (OXA) has been shown to play a protective role against neurological diseases by modulating inflammatory response through activation OXR1 OXR2 receptors. OXA in mediating neuroprotective effects SAE not yet reported.
Earlier experiments in this laboratory identified a highly expressed 65-68-kDa protein both mouse and human corneas (Cuthbertson, R. A. , Tomarev, S. I., Piatigorsky J. (1992) Proc. Natl. Acad. Sci. U. 89, 4004-4008). Here, we demonstrate that is transketolase (TKT; EC 2.2.1.1), an enzyme the nonoxidative branch of pentose-phosphate pathway, based on peptide cDNA isolation sequence analysis cornea RNA samples, respectively. While at low levels number tissues, 2.1-kilobase TKT mRNA was...
This study was designed to investigate the effects of inquiry chemical experiment in chemistry teaching promoting preservice teachers' critical thinking skills. A pretest and posttest experimental design with a comparison group employed validate effectiveness proposed approach. Ten experiments were selected, 42 teachers aged at 19-22 voluntarily participated research. The California Critical Thinking Skills Test (CCTST) used assess level CCTST pre post scores training have significant...
Abstract Glioblastoma (GBM) exhibits significant intratumor heterogeneity (ITH), indicating the presence of tumor cells with diverse growth rates. Here, we aimed to identify fast‐growing in GBM and elucidate underlying mechanisms. Precisely targeting these could offer an improved treatment option. Our results found that ALKBH5 expression impaired proliferation stemness. Nuclear but not overall differs between monoclonal derived from same patient different Mechanistically, interacted TAR...
Diabetic nephropathy (DN), associated with high mobility and disability, is the leading cause of end-stage kidney disease worldwide. Dysfunction mammalian target rapamycin (mTOR) pathway reactive oxygen species (ROS) activation in glomeruli main hypnosis for DN progression. However, use mTOR inhibitors treatment remains controversial. In this study, we built a multifunctional selective mechanistic complex 1 (mTORC1) inhibiting nanoplatform (naming as ESC-HCM-B) that targets release ROS near...
The objective of this study was to investigate the association between chronic back pain and urinary incontinence in women.This a cross-sectional, observational study.There are numerous factors associated with development pain, yet little consideration has been given pelvic floor musculature dysfunction which may also cause incontinence. Currently, limited research exists evaluating relationship incontinence.Data from sample 2,341 women Kentucky Women's Health Registry were used for...
Abstract This study was designed to investigate the effects of inquiry chemical experiment in chemistry teaching promoting preservice teachers’ critical thinking dispositions. A pretest and posttest experimental design with a comparison group employed validate effectiveness proposed approach. Ten experiments were selected, 42 teachers aged at 19-22 voluntarily participated research. The California Critical Thinking Disposition Inventory (CCTDI) used assess level skills. CCTDI post scores...
Tibet, a region where average elevation is above 3500 m and socio-economic development relatively lower, was not included in National Oral Health Survey over decades. The cross-sectional study aimed to investigate the status of dental caries associated factors Tibetan adults.Participants aged 35-44, 55-64 65-74 years were selected. Decayed, missing, filled tooth (DMFT), decayed root (DF-Root) canal index (RCI) used evaluate caries. Questionnaire survey on demographic information,...
Introduction With the increasing number of children’s publications that integrate new media technologies in global publishing community, understanding adoption and use these from a child’s perspective is great significance for both education practitioners industry. Methods This article integrates dual-effect path based on utilitarian-motivation system (UMS) hedonic-motivation (HMS) information technology via questionnaire, systematically demonstrating psychological mechanism reading with...
This study aimed to explore the underlying mechanisms of sepsis and acute kidney injury (AKI), including sepsis-associated AKI (SA-AKI), a frequent complication in critically ill patients.
In expressive and controllable Text-to-Speech (TTS), explicit prosodic features significantly improve the naturalness controllability of synthesised speech. However, manual prosody annotation is labor-intensive inconsistent. To address this issue, a two-stage automatic pipeline novelly proposed in paper. first stage, we use contrastive pretraining Speech-Silence Word-Punctuation (SSWP) pairs to enhance information latent representations. second build multi-modal annotator, comprising...
Functional dyspepsia (FD) is known to be influenced by gut microbiota (GM) and circulating inflammatory proteins (CIPs), however, the causal relationship between GM, CIPs FD haven't been investigated. This study employed two-sample Mendelian Randomization (TSMR) investigate their associations using data from Genome-Wide Association Studies (GWAS). In this study, Inverse-variance weighted (IVW) method was as primary analysis, with supplementary approaches including median, mode, simple...
Abstract Background Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation prognostic marker adult diffuse gliomas. Methods In this study, we investigated expression surgical glioma tissue samples. addition, conducted bisulfite amplicon sequencing (BSAS) methylation-specific PCR (MSP) evaluate glioblastoma (GBM) cells. Subsequently, biological...
Abstract Background Whether there is a causal association between digoxin and mortality among patients with atrial fibrillation (AF), or without congestive heart failure (HF), has been controversial; in particular, two prior analyses of data from the Atrial Fibrillation Follow‐up Investigation Rhythm Management (AFFIRM) trial have yielded conflicting results. We sought to investigate how impacts mortality, full AFFIRM cohort for various subgroups, by applying marginal structural modeling...
Interactive book reading (IBR) has proven effective for increasing children’s lexicons with most of the results based on students’ learning nouns. Little is known about application IBR to instructional verbs (i.e., words used during instruction academic content). To address this gap, 122 prekindergarten children were recruited from seven elementary schools. Each school was randomly assigned intervention group or control group. Children in taught 12 across a 3-week period using interactive...
Based upon the subject librarian training practice of CALIS Phase III "Librarian Literacy Training and Qualification Certification" in charge Shanghai Jiao Tong University Library, this paper elaborates a design for system concerning objectives, methods, courses, tests, organization management mechanisms. From November 2010 to December 2011, program has held four phases liaison respectively trained 322 liaisons 197 universities China. Additionally, it analyzes major characteristics points...
There is an increasing interest in processing data described by graph structures resulting signal (GSP) and neural networks (GNN). One of the fundamental problems GSP learning, which uncovers network topology from signals measured at vertices. However, most existing approaches to learning merely look functional mapping smooth without considering signals' regressors. This paper proposes a novel algorithm (GLReg) for on other regressors, smoothness their relationship with The theoretical...