A5100361352- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Lipid metabolism and biosynthesis
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Effects of Environmental Stressors on Livestock
- Muscle Physiology and Disorders
- Genetic and Kidney Cyst Diseases
- Genomic variations and chromosomal abnormalities
- Ruminant Nutrition and Digestive Physiology
- Forensic and Genetic Research
- Renal and related cancers
- Sustainability and Ecological Systems Analysis
- Gut microbiota and health
- Muscle metabolism and nutrition
Sichuan Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2022-2025
China Three Gorges University
2025
Xinjiang Institute of Ecology and Geography
2024-2025
Chinese Academy of Sciences
2013-2025
Xiamen University
2025
Bavarian Research Alliance
2025
South China Agricultural University
2020-2024
University of Science and Technology of China
2022-2024
Yunnan Agricultural University
2024
Uncoupling protein 1 (UCP1) is a crucial located in the mitochondrial inner membrane that mediates nonshivering thermogenesis. However, molecular mechanisms by which enhancer–promoter chromatin interactions control Ucp1 transcriptional regulation brown adipose tissue (BAT) are unclear. Here, we employed circularized chromosome conformation capture coupled with next-generation sequencing (4C-seq) to generate high-resolution interaction profiles of interscapular (iBAT) and epididymal white...
Abstract Comparative population genomics analysis is an effective approach to identify selection signatures in farm animals. In this study, we systematically investigated the six phenotypically diverse goat breeds using SNPs obtained from pooled whole-genome resequencing data. More than 95.5% of 446–642 million clean reads were mapped latest reference genome, which generated a sequencing depth ranging 22.30 31.75-fold for each breed. A total 5,802,307, 6,794,020, 7,562,312, 5,325,119,...
Research studies have recently focused on circle RNAs (circRNAs) in relation to their regulatory functions animals. However, the systematic identification of circRNAs plants, especially non-model is limited. In addition, raw report prediction potential role plant response pathogen invasion currently available. We conducted from four materials originating three species belonging genus Actinidia under different situations using ribosomal RNA (rRNA) depleted RNA-Seq data. A total 3,582 were...
Long non-coding RNAs (lncRNAs) have been studied extensively over the past few years. Large numbers of lncRNAs identified in mouse, rat, and human, some them shown to play important roles muscle development myogenesis. However, there are reports on characterization covering all stages skeletal livestock. RNA libraries constructed from developing longissimus dorsi fetal (45, 60, 105 days gestation) postnatal (3 after birth) goat (Capra hircus) were sequenced. A total 1,034,049,894 clean reads...
Exosome-encapsulated microRNAs (miRNAs) are being considered as either diagnostic or predictive markers in different types of diseases. Here, we discussed the effects exosome-encapsulated miR-127-3p from bone marrow-derived mesenchymal stem cells (BM-MSCs) on osteoarthritis (OA).BM-MSCs and primary chondrocytes were isolated Sprague Dawley rats. IL-1β was utilized to treat mimic an OA vitro model, exosomes extracted BM-MSCs so verify their protective OA. Through online website prediction...
Cilia are microtubule-based protrusions from the cell surface that involved in a number of essential signaling pathways, yet little is known about many proteins regulate their structure and function. A putative cilia genes have been identified by proteomics comparative sequence analyses, but functional data lacking for vast majority. We therefore monitored effects three lines small interfering RNA (siRNA) knockdown 40 these high-content analysis. assayed number, length, transport two...
Although obstructive sleep apnea (OSA) is known to have a strong familial basis, no genetic polymorphisms influencing risk been identified in cross-cohort analyses. We utilized the National Heart, Lung, and Blood Institute (NHLBI) Candidate Gene Association Resource (CARe) identify susceptibility loci. Using panel of 46,449 from roughly 2,100 candidate genes on customized Illumina iSelect chip, we tested for association with hypopnea index (AHI) as well moderate severe OSA (AHI≥15) 3,551...
This study demonstrated berberine to be a potential natural compound against Actinobacillus pleuropneumoniae. Liquid doubling dilution, transmission electron microscopy (TEM), SDS-PAGE and 4′,6-diamidino-2-phenylindole (DAPI) staining were employed elucidate the antibacterial activity mechanism of berberine. The minimal inhibitory concentration was 0.3125 mg/mL, time–kill curves showed time dependence. TEM micrographs displayed damaged cell wall, concentrated cytoplasm, cytoplasmic content...
Adaptive thermogenesis by brown adipose tissue (BAT) is important to the maintenance of temperature in newborn mammals. Cold exposure activates gene expression and lipid metabolism provide energy for BAT thermogenesis. However, knowledge large animals after cold still limited.In this study, we found that induced genes increased protein levels UCP1 PGC1α. Pathway analysis showed activated metabolism, which involved cGMP-PKG, TCA cycle, fatty acid elongation, degradation pathways. These were...
β-1,4-N-acetylgalactosamine transferase 2 (B4GALNT2) is a vital candidate gene that affects the growth traits in sheep. However, whether it has same function goats remains to be investigated further. This study selected 348 Nanjiang Yellow goats, screened all exons, and conserved non-coding regions of B4GALNT2 for single-nucleotide polymorphisms (SNPs). Our results revealed presence synonymous mutation, rs672215506, within exon goat population. The mutation resulted decrease mRNA stability...
Abstract Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici ( Pst ), is an air-borne fungal disease, and its spores can be spread far away from origin to colonize in new territory, causing inter-regional epidemics. Xinjiang not only important independent epidemic region other rust epidemiological regions China but also has distinguished genetic structure spatial features. However, the inoculum source of remained unknown. It clear whether inocula Central Asian countries migrate...
Introduction: Recent investigations have underscored the importance of long non-coding RNAs (lncRNAs), which exhibit more specific expression in tissues and cells than mRNA are involved gene regulation during development, pathology, other processes through various mechanisms. Despite predominant focus on role lncRNA Dio3os cancer research, there has been relatively limited exploration its potential involvement glycolipid metabolism. Therefore, this study aims to consolidate existing...
Previous research has identified several potential biomarkers associated with pathological tumor (pT) staging in prostate cancer (PCa) patients. Among these biomarkers, CX3CR1 is notable for its connection to the immune microenvironment.. To further investigate significance of as a key biomarker predicting pT staging and PCa progression.. Prostate tissue samples were analyzed using quantitative reverse transcription polymerase chain reaction (qRT-PCR) immunohistochemical staining. The...