A5054989034- Cell Image Analysis Techniques
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Growth Hormone and Insulin-like Growth Factors
- Advanced Image and Video Retrieval Techniques
- RNA modifications and cancer
- Remote-Sensing Image Classification
- Image Processing Techniques and Applications
- Industrial Automation and Control Systems
- Ferroptosis and cancer prognosis
- Gene Regulatory Network Analysis
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Phytochemistry and Biological Activities
- Nanocomposite Films for Food Packaging
- Wnt/β-catenin signaling in development and cancer
- Vitamin C and Antioxidants Research
- Animal Genetics and Reproduction
- Advanced Drug Delivery Systems
- Antimicrobial agents and applications
- Handwritten Text Recognition Techniques
- Genetic Mapping and Diversity in Plants and Animals
Yancheng Institute of Technology
2025
Fudan University
2025
Zhongshan Hospital
2025
Broad Institute
2023-2024
Qilu University of Technology
2024
Shandong Academy of Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Sichuan Agricultural University
2021-2024
Nanjing Municipal Center for Disease Control And Prevention
2023
Ji Hua Laboratory
2022
Obesity, a surging global health challenge, necessitates effective, accessible and innovative therapeutic models. Here we develop spatiotemporally controllable microneedle (MN) drug delivery platform for sono-gene therapy to fight obesity. The delivers the methoxy polyethylene glycol-polyethyleneimine (mPEG-PEI) modified metal-organic frameworks (MOFs) sonosensitizer clustered regularly interspaced short palindromic repeats-activating (CRISPRa)/CRISPRa-uncoupling protein 1 (UCP1) system...
Abstract Accurately quantifying cellular morphology at scale could substantially empower existing single-cell approaches. However, measuring cell remains an active field of research, which has inspired multiple computer vision algorithms over the years. Here, we show that DINO, a vision-transformer based, self-supervised algorithm, remarkable ability for learning rich representations without manual annotations or any other type supervision. We evaluate DINO on wide variety tasks across three...
β-1,4-N-acetylgalactosamine transferase 2 (B4GALNT2) is a vital candidate gene that affects the growth traits in sheep. However, whether it has same function goats remains to be investigated further. This study selected 348 Nanjiang Yellow goats, screened all exons, and conserved non-coding regions of B4GALNT2 for single-nucleotide polymorphisms (SNPs). Our results revealed presence synonymous mutation, rs672215506, within exon goat population. The mutation resulted decrease mRNA stability...
Insulin-like Growth Factor 2 mRNA-binding Protein 1 (IGF2BP1) is a candidate gene of significant interest for modulating economically important traits in livestock and poultry. The second intron IGF2BP1 has been implicated growth-related traits, though its precise mechanistic role remains elusive. Initial resequencing analyses our laboratory indicated strong selective pressures on the genomic region, prompting selection identification several single nucleotide polymorphisms (SNPs). Seven...
Abstract The "watershed transformation" is a well‐known powerful tool for automated image segmentation. However, it often computationally expensive and can produce over‐segmentation in situations of high gradient noise, quantity error detailed texture. Here, new method has been designed to overcome these inherent drawbacks. After pre‐processing the imagery using nonlinear filter order an optimized watershed transformation applied provide initial segmentation result. Then, multi‐scale,...
<i>Forsythia suspensa</i>, belonging to the deciduous shrubs of Luteaceae family, a traditional Chinese medicine, has effects alleviating swelling, clearing heat, detoxification and promoting blood circulation. The leaves suspensa</i> contain multiple chemical components have long history use in folk medicines health foods. purpose this study was explore forsythin extract from on intestinal microbiota short chain fatty acid (SCFA) content rats with obesity induced by high-fat diet. Forsythin...
Design is an iterative process that aims at problem-solving. While the importance of mental iteration has been identified, there are little research on how to improve in design process. In this paper, we propose a method augment by AI. An experiment was conducted study effect AI iteration. The results indicate could designers' performance fluency and stylization.
Abstract Insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) plays essential roles in the proliferation of skeletal muscle satellite cells (MuSCs). Increasing evidence has shown that IGF2BP1 regulates expression noncoding RNAs and mRNAs. However, related molecular network remains to be fully understood. Therefore, we performed RNA sequencing analyzed microRNAs (miRNAs), long (lncRNAs), mRNAs differentially expressed goat MuSCs treated with overexpressing empty vectors. A total 36...
Insulin-like Growth Factor 2 mRNA binding Protein 1 (IGF2BP1) is a promising candidate gene for influencing economic traits in livestock and poultry. The second intronic region of IGF2BP1 closely related to growth traits, although the exact mechanism remains unclear. preliminary resequencing results goats our laboratory demonstrated that was subject strong selection, then we selected multiple single nucleotide polymorphisms (SNPs) identify. Seven SNPs were located conserved intron, their...
Cell Painting images offer valuable insights into the state of a cell and enable many biological applications, but publicly available arrayed datasets only include hundreds genes perturbed. The JUMP (Joint Undertaking in Morphological Profiling) Consortium perturbed roughly 75% protein-coding genome human U-2 OS cells, generating rich resource single-cell extracted features. These profiles capture phenotypic impacts perturbing 15,243 genes, including overexpressing 12,609 (using open reading...
Bladder cancer (BC) is the most common malignant tumour of urinary system and one leading causes cancer-related death. Cuproptosis a novel form programmed cell death, its mechanism in tumours remains unclear. This study aimed to establish prognostic signatures cuproptosis-related lncRNAs determine their clinical value. RNA sequencing data from The Cancer Genome Atlas were used detect expression levels genes BC. Cuproptosis-related linked survival identified using co-expression univariate Cox...
Museum exhibitions on traditional Chinese paintings are gaining popularity for educational and cultural value. characterized by a long history implicit emotional expression, it is challenging non-professional non-Chinese visitors to understand. To enhance museum visitors' interest comprehension of artworks, we design an EEG-based interactive installation. The installation simulates the process creation work art, in this case painting. Visitors can control generation lines, colors, movements...
B4GALNT2 is a vital candidate gene that affects the growth traits litter size in and of sheep, but whether it has same function goats remains to be further investigated. In this study, we utilized 348 Nanjiang Yellow as experimental subjects, conducted whole exon, conserved non-coding region SNP scanning gene. Our results revealed presence synonymous mutation, rs672215506, within exon goat population. This mutation was found associated with reduced mRNA stability The SNPs detection showed...
Most neural networks assume that input images have a fixed number of channels (three for RGB images). However, there are many settings where the may vary, such as microscopy changes depending on instruments and experimental goals. Yet, has not been systemic attempt to create evaluate invariant type channels. As result, trained models remain specific individual studies hardly reusable other settings. In this paper, we present benchmark investigating channel-adaptive in imaging, which consists...
Abstract Aim To investigate the role of iodine‐125 ( 125 I) combined with epirubicin (EPI) in inhibiting hepatocellular carcinoma (HCC) growth and promoting apoptosis. Methods Both vivo vitro experiments were conducted. CCK‐8 assay was performed to determine cells viability after EPI treatment. HepG2 SMMC7721 treated or I combination. Colony formation assays verify antiproliferation effect. Annexin V–FITC/PI, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays,...
Proposes a new splitting algorithm for two-letter state name (state-name abbreviation) segmentation to recognize the on mail pieces. The merit of this is that point located near center 0-projections, and it especially effective images in which widths each latter are different, such as "IN", "HI", "WI" "MI". performance tested by real USPS envelopes. correct rate obtained 95.4% (91.7% Kimura's method) (932 images).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML"...