A5091119648- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Coronary Artery Anomalies
- Cardiac and Coronary Surgery Techniques
- Pluripotent Stem Cells Research
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Issues in Pregnancy
- Cardiovascular and Diving-Related Complications
- Cardiac, Anesthesia and Surgical Outcomes
- CRISPR and Genetic Engineering
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Tracheal and airway disorders
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
Deutsches Herzzentrum München
2016-2025
German Centre for Cardiovascular Research
2016-2025
Technical University of Munich
2015-2024
Paracelsus Medizinische Privatuniversität
2016-2024
Nuremberg Hospital
2000-2021
Klinikum rechts der Isar
2002-2021
München Klinik
2007-2020
Stanford University
2017
Deutsches Herzzentrum der Charité
1999-2015
University Medical Center Freiburg
2008-2012
Although transcatheter aortic-valve replacement (TAVR) is an accepted alternative to surgery in patients with severe aortic stenosis who are at high surgical risk, less known about comparative outcomes among intermediate risk.We evaluated the clinical intermediate-risk severe, symptomatic a randomized trial comparing TAVR (performed use of self-expanding prosthesis) replacement. The primary end point was composite death from any cause or disabling stroke 24 months undergoing attempted We...
Transcatheter aortic valve implantation was developed to mitigate the mortality and morbidity associated with high-risk traditional replacement. The Edwards SAPIEN approved for transcatheter transfemoral delivery in European Union November 2007 transapical January 2008.The Aortic Bioprosthesis Outcome (SOURCE) Registry designed assess initial clinical results of consecutive patients Europe after commercialization. Cohort 1 consists 1038 enrolled at 32 centers. Patients who were treated...
Transcatheter aortic valve implantation was developed to provide a therapeutic option for patients considered be ineligible for, and mitigate mortality morbidity associated with, high-risk surgical replacement.The Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry designed assess initial post commercial clinical transcatheter results of the in consecutive Europe. Cohort 1 consists 1038 enrolled at 32 centers. One-year outcomes are presented. Patients with transapical...
Abstract The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge identity quantity constituent proteins still lacking. Here, we determine healthy proteome by measuring 16 anatomical regions three major cardiac cell types high-resolution mass spectrometry-based proteomics. From low microgram sample amounts, quantify over 10,700 in this high dynamic range tissue. We combine copy numbers per with protein organellar assignments to...
Abstract Monoclonal Abs against CD20 reduce the number of relapses in multiple sclerosis (MS); commonly this effect is solely attributed to depletion B cells. Recently, however, a subset CD3+CD20+ T cells has been described that also targeted by anti-CD20 mAb rituximab. Because existence coexpressing CD3 and controversial features subpopulation are poorly understood, we studied issue detail. In study, confirm 3–5% circulating human display on their surface transcribe both CD20. We report...
In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter replacement (TAVR) a self-expanding supra-annular was noninferior to surgery for all-cause mortality or disabling stroke 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these are limited.To report prespecified secondary 5-year from the Symptomatic Aortic Stenosis Intermediate Risk Subjects Who Need Valve Replacement (SURTAVI) randomized trial.SURTAVI is prospective randomized,...
The German Aortic Valve Registry (GARY) seeks to provide information on a real-world, all-comers basis for patients undergoing aortic valve interventions. This registry comprises the complete spectrum of transcutaneous and conventional surgical aim this study was use GARY evaluate catheter-based interventions in several risk groups. A total 13 860 consecutive intervention disease [conventional replacement (AVR) or transvascular/transapical TAVR (TV-/TA-TAVR)] were enrolled 78 centres 2011....
We explored interhemispheric facilitation (IHF) between (a) left and right primary motor cortex (M1) (b) dorsal premotor (dPM) M1 in 20 right-handed healthy human subjects using a paired pulse transcranial magnetic stimulation (TMS) protocol. A conditioning TMS (CP) applied to or dPM with an intensity of 80% 60% active threshold (CP(80%AMT) CP(60%AMT), respectively) was followed by test (TP) over induced anterior-posterior- posterior-anterior- (TP(AP), TP(PA)) directed currents the brain at...
This analysis presents the first report of 1-year outcomes 120 patients enrolled in REPRISE II (Repositionable Percutaneous Placement Stenotic Aortic Valve Through Implantation Lotus System–Evaluation Safety and Performance) study. The fully repositionable retrievable (Boston Scientific, Marlborough, Massachusetts) was designed to facilitate accurate positioning, early valve function, hemodynamic stability during deployment minimize paravalvular regurgitation undergoing transcatheter aortic...
<b>Background</b> The increasing prevalence of severe aortic valve defects correlates with the increase life expectancy. For decades, surgical replacement (AVR), under use extracorporeal circulation, has been gold standard for treatment diseases. In Germany ~12,000 patients receive isolated surgery per year. some time, percutaneous balloon valvuloplasty used as a palliative therapeutic option very few patients. Currently, alternatives established procedures such transcatheter implantation...
This study aims to evaluate the clinical outcome following total cavopulmonary connection (TCPC) and identify factors affecting early late outcome.Between May 1994 March 2015, 434 patients underwent TCPC with 50 lateral tunnels 374 extracardiac conduits. The outcome, exercise capacity liver examination results were retrospectively reviewed.Thirty-day survival was 98.2%, estimated rate at 15 years 92.3%. Freedom from tachyarrhythmia 91.0%. Other morbidities included bradyarrhythmia in 17,...
The study analyses the outcome of patients undergoing transcatheter aortic valve implantation (TAVI) for different subtypes severe stenosis (AS) based on data from GARY registry.Low-EF, low-gradient (LEF-LGAS: EF ≤40%, MPG <40 mmHg), paradoxical (PLF-LGAS: ≥50%, mmHg) and high-gradient AS (HGAS: ≥40 were observed in 11.7% (n=359), 20.8% (n=640) 60.6% (n=1,864) population, respectively. EuroSCORE I (36.7±20.9 vs. 22.6±15.7 24.3±17.4; p<0.001) differed significantly among subgroups....
We sought to determine the long-term outcome of high-risk patients who underwent transcatheter aortic valve replacement (TAVR) with first-generation devices a focus on identification predictors for mortality and durability.Consecutive in our prospective single-centre registry undergoing TAVR (n=214 CoreValve; n=86 SAPIEN) between 06/2007 07/2009 were retrospectively analysed (n=300, mean age 81.43±6.55 years, STS score 6.5±4.5%). Kaplan-Meier estimates survival Cox proportional hazards model...
Background —Coronary reimplantation is used in therapy for congenital heart disease, such as the arterial switch (ASO) and Ross operations. The adequacy of myocardial perfusion may remain a matter concern. aim present study was to stratify effect coronary on highlight clinical relevance any attenuation perfusion. Methods Results —A total 21 children with transposition great arteries at mean interval 11.2±2.9 years after ASO 9 adolescents 4.2±2.1 procedure were investigated. All patients...