A5070234793- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Action Observation and Synchronization
- Visual perception and processing mechanisms
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Spatial Neglect and Hemispheric Dysfunction
- Motor Control and Adaptation
- Eating Disorders and Behaviors
- Attention Deficit Hyperactivity Disorder
- Transcranial Magnetic Stimulation Studies
- Reading and Literacy Development
- Neuroscience and Music Perception
- Genetic Neurodegenerative Diseases
- Neural and Behavioral Psychology Studies
- Pain Mechanisms and Treatments
- Hemispheric Asymmetry in Neuroscience
- MRI in cancer diagnosis
- Stroke Rehabilitation and Recovery
- Pain Management and Placebo Effect
- Phonetics and Phonology Research
- Neural dynamics and brain function
- Neurological disorders and treatments
- Language, Metaphor, and Cognition
University of Freiburg
2011-2024
Hudson Institute
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
University Medical Center Freiburg
2009-2022
King's College London
2017
Bernstein Center for Computational Neuroscience Freiburg
2007-2014
Medical University of Vienna
2008
Universität Hamburg
2001-2007
University Medical Center Hamburg-Eppendorf
2004-2007
Built on an analogy between the visual and auditory systems, following dual stream model for language processing was suggested recently: a dorsal is involved in mapping sound to articulation, ventral meaning. The goal of study presented here test neuroanatomical basis this model. Combining functional magnetic resonance imaging (fMRI) with novel diffusion tensor (DTI)-based tractography method we were able identify most probable anatomical pathways connecting brain regions activated during...
Only recently have neuroimaging studies moved away from describing regions activated by noxious stimuli and started to disentangle subprocesses within the nociceptive system. One approach characterizing role of individual is record brain responses evoked different stimulus intensities. We used such a parametric single-trial functional MRI design in combination with thulium:yttrium-aluminium-granate infrared laser investigated pain, intensity awareness (i.e. pain-unrelated) nine healthy...
Neuroimaging studies have demonstrated activations in the anterior cingulate cortex (ACC) related to affective component of pain, but not stimulus intensity. However, it is possible that low spatial resolution positron emission tomography, as used majority these studies, obscured areas coding We revisited this issue, using a parametric single-trial functional magnetic resonance imaging design, and investigated intensity, awareness (i.e., pain unrelated) responses within ACC nine healthy...
Converging evidence from neuroimaging studies and computational modelling suggests an organization of language in a dual dorsal–ventral brain network: dorsal stream connects temporoparietal with frontal premotor regions through the superior longitudinal arcuate fasciculus integrates sensorimotor processing, e.g. repetition speech. A ventral temporal prefrontal via extreme capsule mediates meaning, auditory comprehension. The aim our study was to test, large sample 100 aphasic stroke...
According to the basal ganglia-thalamocortical circuit model, dopamine depletion in nigrostriatal system leads hypoactivation supplementary motor area (SMA) and primary cortex (M1) Parkinson's disease. This functional cortical deafferentation its reversibility by levodopa (L-dopa) treatment has been established previous studies for SMA but remains controversial M1. We used MRI (fMRI) a simple finger opposition task correlate blood oxygenation level-dependent (BOLD) signal changes with...
In the present study, we identified most probable trajectories of point-to-point segregated connections between functional attentional centers using a combination magnetic resonance imaging and novel diffusion tensor imaging-based algorithm for pathway extraction. Cortical regions activated by visuospatial attention task were subsequently used as seeds probabilistic fiber tracking in 26 healthy subjects. Combining probability maps frontal temporoparietal yielded network that consisted dorsal...
Background. Mirror therapy (MT) is a promising therapeutic approach in stroke patients with severe hand paresis. Objective. The ipsilateral (contralesional) primary sensorimotor cortex (SMC) and the mirror neuron system have been suggested to play decisive roles MT network. present study investigated its underlying neural plasticity. Methods. Two groups of healthy participants (n = 13 each group) performed standardized fine motor tasks moving pegs marbles (20 min/d for 4 days) their right...
Perception of surface orientation is an essential step for the reconstruction three-dimensional (3D) structure object. Human lesion and functional neuroimaging studies have demonstrated importance parietal lobe in this task. In primate single-unit studies, neurons caudal part intraparietal sulcus (CIP) were found to be active during extraction through monocular (two-dimensional) cues such as texture gradients linear perspective well binocular disparity gradient disparity. We used...
THE present study addresses phonological processing in children with developmental dyslexia. Following the hypothesis of a core deficit assembled phonology dyslexia set hierarchically structured tasks was applied that specifically control for different kinds coding (assembled versus addressed strategies). Seventeen dyslexics and 17 normal reading were scanned during four tasks: (1) passive viewing letter strings (control condition), (2) non-words, (3) legal words, (4) task requiring...
In the monkey lateral bank of anterior part intraparietal sulcus (area AIP), contains neurons that are involved in visually guided, object-related hand movements. It has also been shown caudal CIP) preferentially respond to 3D surface orientation. According these results, it hypothesized area CIP primarily encode features an object and forwards this information AIP. AIP then utilizes for appropriate actions towards object. Based on analogies primate studies, recent neuroimaging studies have...
Background Cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) is the psychotherapeutic treatment of choice for obsessive–compulsive disorder (OCD). However, little known about impact CBT on frontostriatal dysfunctioning, to be neuronal correlate OCD. Method A probabilistic reversal learning (RL) task probing adaptive strategy switching capabilities was used in 10 unmedicated patients OCD healthy controls during an event-related functional magnetic resonance...
The neural mechanisms underlying spatial neglect are still disputed. Abnormal left parietal hyperactivation is proposed to lead the rightward attentional bias, a clinical hallmark of neglect. Extinction, another deficit visuospatial attention, regarded as either 'mild' form or distinct syndrome. Although both and extinction typical syndromes acute right hemispheric stroke, all imaging studies investigating these were conducted at least several weeks after stroke onset, in phase when brain...
Numerical cognition is a case of multi-modular and distributed cerebral processing. So far neither the anatomo-functional connections between cortex areas involved nor their integration into established frameworks such as differentiation dorsal ventral processing streams have been specified. The current study addressed this issue combining re-analysis previously published fMRI data with probabilistic fiber tracking from an independent sample. We aimed at differentiating neural correlates...
Objectives. Affective dysregulation is a clinical hallmark of borderline personality disorder (BPD). This study used an instructed fear task combined with functional MRI (fMRI) and skin conductance response (SCR) to test hypotheses about mechanisms disturbed fronto-limbic neural circuitry underlying dysfunctional emotional processing in BPD. Methods. Female BPD patients matched control subjects were exposed two visual stimuli during fMRI scanning SCR recording. Subjects shortly before that...
Background and Purpose — Diffusion-weighted MR imaging is very sensitive for the detection of restricted molecular water diffusion in acute ischemic stroke. CT to net uptake edema. We compared decrease apparent coefficient (ADC) diffusion-weighted with density changes study correlation between restriction stroke patients. Methods Twenty-five patients anterior cerebral circulation underwent 1.3 5.4 hours after symptom onset. ADC data were transferred into a common 3-dimensional space, regions...
BackgroundLearning to play a musical piece is prime example of complex sensorimotor learning in humans. Recent studies using electroencephalography (EEG) and transcranial magnetic stimulation (TMS) indicate that passive listening melodies previously rehearsed by subjects on instrument evokes differential brain activation as compared with unrehearsed melodies. These changes were already evident after 20–30 minutes training. The exact regions involved these responses have not yet been...