A5074730046- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- NMR spectroscopy and applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Electron Spin Resonance Studies
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Neurotransmitter Receptor Influence on Behavior
- Coronary Interventions and Diagnostics
- Neural and Behavioral Psychology Studies
- Solid-state spectroscopy and crystallography
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Lanthanide and Transition Metal Complexes
- Aortic Thrombus and Embolism
University of Freiburg
2016-2025
Justus-Liebig-Universität Gießen
2005-2024
Fraunhofer Institute for Digital Medicine
2018-2024
Charité - Universitätsmedizin Berlin
1995-2024
University Hospital and Clinics
2024
University Medical Center Freiburg
2014-2023
Faculty (United Kingdom)
2021
Bernstein Center for Computational Neuroscience Freiburg
2007-2020
Brain (Germany)
2007-2020
Technical University of Darmstadt
2020
Abstract Based on the principles of echo imaging, we presnet a method to acquire sufficient data for 256 × image in from 2 40s. The contrast is dominated by transverse relaxation time T Sampling all projections 2D FT reconstruction one (or few) trains leads artifacts due different weighting echo. These cannot be described simple smearing out phase direction. Proper distribution phase‐encoding steps echoes can used minimize and even lead resolution enhancement. In spite short acquisition...
Built on an analogy between the visual and auditory systems, following dual stream model for language processing was suggested recently: a dorsal is involved in mapping sound to articulation, ventral meaning. The goal of study presented here test neuroanatomical basis this model. Combining functional magnetic resonance imaging (fMRI) with novel diffusion tensor (DTI)-based tractography method we were able identify most probable anatomical pathways connecting brain regions activated during...
The concept of schizotypy or "psychosis proneness" captures individual differences in perceptual, cognitive, and affective experiences that may relate to a range psychotic disorders. is an important way assess the contribution pre-existing psychological genetically based biological features development illnesses such as schizophrenia (so called endophenotypes). Oxford-Liverpool Inventory Feelings Experiences (O-LIFE) widely used multi-dimensional measure construct consists four scales which...
PTK787/ZK 222584 (PTK/ZK), an orally active inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, inhibits VEGF-mediated angiogenesis. The pharmacodynamic effects PTK/ZK were evaluated by assessing changes in contrast-enhancement parameters metastatic liver lesions using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) patients with advanced colorectal cancer treated two ongoing, dose-escalating phase I studies.Twenty-six had DCE-MRI performed at...
Abstract Quantification of CINE phase contrast (PC)‐MRI data is a challenging task because the limited spatiotemporal resolution and signal‐to‐noise ratio (SNR). The method presented in this work combines B‐spline interpolation Green's theorem to provide optimized quantification blood flow vessel wall parameters. model provided optimal derivatives measured three‐directional velocities onto contour, as required for vectorial shear stress (WSS) computation. Eight planes distributed along...
Recent in vivo studies using proton magnetic resonance (1H-MR) spectroscopy showed low levels of myo-inositol the brain hepatic encephalopathy; pathogenetic relevance this observation is unclear.Myo-inositol and glutamine were studied by 1H-MR patients with hypo-osmolarity encephalopathy.A patient severe plasma (222 mOsm/L) had almost undetectable signals for glutamine/glutamate brain. Both reappeared after normalization osmolarity, suggesting that both released as organic osmolytes from A...
Abstract Purpose To evaluate an improved image acquisition and data‐processing strategy for assessing aortic vascular geometry 3D blood flow at 3T. Materials Methods In a study with five normal volunteers seven patients known pathology, prospectively ECG‐gated cine three‐dimensional (3D) MR velocity mapping navigator gating, real‐time adaptive k‐space ordering dynamic adjustment of the acceptance criteria was performed. addition to morphological information three‐directional velocities,...
Neural correlates of electroencephalographic (EEG) alpha rhythm are poorly understood. Here, we related EEG in awake humans to blood-oxygen-level-dependent (BOLD) signal change determined by functional magnetic resonance imaging (fMRI). Topographical was recorded simultaneously with fMRI during an open versus closed eyes and auditory stimulation silence condition. separated into spatial components maximal temporal independence using independent component analysis. Alpha amplitudes stimulus...
Abstract Echo‐planar imaging (EPI) is an ultrafast magnetic resonance (MR) technique prone to geometric distortions. Various correction techniques have been developed remedy these Here improvements of the point spread function (PSF) mapping approach are presented, which enable reliable and fully automated distortion echo‐planar images at high field strengths. The novel method compatible with EPI acquisitions using parallel imaging. applicability further accelerate PSF acquisition shown....
The theory on the glymphatic convection mechanism of cerebrospinal fluid holds that cardiac pulsations in part pump from peri-arterial spaces through extracellular tissue into peri-venous facilitated by aquaporin water channels. Since pulses cannot be sole propulsion, we searched for additional human brain with ultra-fast magnetic resonance encephalography. We detected three types physiological mechanisms affecting cerebral pulsations: cardiac, respiratory, and very low frequency pulsations....
Diffusion-sensitized magnetic resonance imaging probes the cellular structure of human brain, but primary microstructural information gets lost in averaging over higher-level, mesoscopic tissue organization such as different orientations neuronal fibers. While is inevitable due to limited resolution, we propose a method for disentangling microscopic cell properties from effects structure. We further avoid classical fitting paradigm and use supervised machine learning terms Bayesian estimator...
We have examined the activity levels produced in various areas of human occipital cortex response to motion stimuli using functional magnetic resonance imaging (fMRI) methods. In addition standard luminance-defined (first-order) motion, three types second-order were used. The area V5 (MT) and following that delineated retinotopic mapping procedures: V1, V2, V3, VP, V3A, a new we refer as V3B. Area is strongly activated by well first-order motion. This activation highly motion-specific. Areas...
<h3>Context</h3> A characteristic feature of borderline personality disorder (BPD) is self-injurious behavior in conjunction with stress-induced reduction pain perception. Reduced sensitivity has been experimentally confirmed patients BPD, but the neural correlates antinociceptive mechanisms BPD are unknown. We predicted that heat stimuli would activate brain areas concerned cognitive and emotional evaluation pain. <h3>Objective</h3> To assess psychophysical properties altered processing...
To better understand variations in spectra of brain tumors, 122 vivo proton tumors 82 patients were analyzed. The changes relative metabolite concentrations compared with those normal and the presence any new assessed. evaluate clinical usefulness hydrogen-1 magnetic resonance (MR) spectroscopy authors looked for specific spectral on basis tumor grade. All showed differences from reference spectra. differential diagnosis was limited because intraindividual between one at different locations...
Abstract A spectroscopic MR technique was used to investigate the time course of signal following a single visual stimulus. Gated experiments demonstrate there is an early response (500 ms after stimulus) leading reduction by −0.25% ( P = 0.02), whereas slower (>1500 results in increase +0.59% 0.01). The fast negative may be attributed increased oxygen consumption, followed vascular with overcompensation blood oxygenatioln. This explanation would agreement oxygenation level dependent...
Morphometric analysis of magnetic resonance imaging brain scans was used to investigate possible neuroanatomic differences between patients with primary insomnia compared good sleepers.MRI images (1.5 Tesla) the were obtained from and sleepers. MRI analyzed bilaterally by manual morphometry for different areas including hippocampus, amygdala, anterior cingulate, orbitofron-tal dorsolateral prefrontal cortex.University Hospital Sleep Center Radiology Department8 unmedicated physician-referred...
A variation of the rapid acquisition with relaxation enhancement (RARE) sequence (also called turbo spin-echo (TSE) or fast (FSE)) is presented. This technique uses variable flip angles along echo train such that magnetization initially prepared into static pseudo steady state (PSS) for a low refocusing angle (alpha < 180 degrees ). It shown after preparation, will always stay very close to PSS even significant subsequent angles. allows design TSE sequences in which high yielding 100%...
Abstract Spin echoes have been known since 1950. Although their formal description by use of the Bloch equations is straightforward, it does not lead to an intuitive understanding behavior except for special cases 180° or 90° pulses, especially when many pulses are applied before magnetization has returned into thermal equilibrium. The extended‐phasegraph algorithm, which takes account that total in spin‐echo sequences a superposition isochromats, allows recognition all possible echo signals...