A5069016381- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Neuroscience and Neuropharmacology Research
- Atomic and Subatomic Physics Research
- Neurological disorders and treatments
- Protein Hydrolysis and Bioactive Peptides
- Medical Imaging Techniques and Applications
- Probiotics and Fermented Foods
- Blind Source Separation Techniques
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Analytical Chemistry and Chromatography
- Neonatal and fetal brain pathology
- Digestive system and related health
- Biochemical Analysis and Sensing Techniques
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
University College London
2016-2025
National Hospital for Neurology and Neurosurgery
2016-2025
Epilepsy Society
2016-2025
Queen Mary University of London
2023
Harvard University
1951-2023
Epilepsy Research UK
1999-2017
Hôpital de la Timone
2012
Universitätsklinikum Erlangen
2012
Policlinico Umberto I
2009-2012
Centre for Mental Health
2011
Abstract Probabilistic atlases of neuroanatomy are more representative population anatomy than single brain atlases. They allow anatomical labeling the results group studies in stereotaxic space, automated individual imaging datasets, and statistical assessment normal ranges for structure volumes extents. No such manually constructed atlas is currently available frequently studied young adults. We 20 subjects (10 women, median age 31 years) with high‐resolution magnetic resonance (MRI)...
Abstract The hippocampus is among the first structures affected in Alzheimer's disease (AD). Hippocampal magnetic resonance imaging volumetry a potential biomarker for AD but hindered by limitations of manual segmentation. We proposed fully automatic method using probabilistic and anatomical priors Probabilistic information derived from 16 young controls knowledge modeled with automatically detected landmarks. results were previously evaluated comparison segmentation on data healthy...
Abstract A cerebral network comprising precuneus, medial frontal, and temporoparietal cortices is less active both during goal‐directed behavior states of reduced consciousness than conscious rest. We tested the hypothesis that interictal epileptic discharges affect activity in these brain regions patients with temporal lobe epilepsy who have complex partial seizures. At group level, using electroencephalography‐correlated functional magnetic resonance imaging 19 consecutive focal epilepsy,...
Abstract The acquisition of electroencephalograms (EEG) during functional magnetic resonance imaging (fMRI) experiments raises important practical issues patient safety. presence electrical wires connected to the in rapidly changing fields results currents flowing through due induced electromotive forces (EMF), by three possible mechanisms: fixed loop gradient fields; a RF electromagnetic field; moving static field. RF‐induced EMFs were identified as most potential hazard. We calculated...
EEG-triggered functional MRI (fMRI) offers the potential to localize generators of scalp EEG events, such as interictal epileptiform discharges, using a biological measurement opposed relying solely on modelling techniques. Although recent studies have demonstrated these possibilities in small number patients, wider application has been limited by concerns about patient safety, severe problems due pulse-related artefact obscuring trace, and lack reproducibility data. We systematically...
Abstract We studied a patient with idiopathic generalized epilepsy and frequent absences, using electroencephalogram‐correlated functional magnetic resonance imaging. Four prolonged runs of spike‐wave discharge occurred during 35‐minute experiment. Time‐locked activation was observed bilaterally within the thalami in conjunction widespread but symmetrical cortical deactivation frontal maximum. demonstrate reciprocal participation focal thalamic networks human absence seizures suggest...
Recurrent episodes with interictal affective aggression are a rare but well-recognized problem in patients temporal lobe epilepsy. They referred to as episodic dyscontrol or, more precisely, intermittent explosive disorder (IED). The amygdala play crucial role the evaluation of multimodal sensory input and neurobiological mediation aggressive behaviour. With hippocampal sclerosis, context mesial being most common cause epilepsy, we hypothesized that might be affected by same pathogenic...
An automatic method for the accurate registration of computed tomography (CT) data with two camera‐calibrated radiographs is presented. The based on skull as visualized both in plain and digitally reconstructed from CT. A reference coordinate system established radiographic projection parameters obtained using an angiographic stereotactic localizer. CT‐derived are aligned iteratively at multiple resolutions until a best match found by adjusting position orientation CT set relative to system....
Visual inspection and volumetric analysis of MRIs allow mesial temporal sclerosis (MTS) to be reliably identified in patients with lobe epilepsy. The presence unilateral MTS ipsilateral the side habitual seizure onset is an indicator for prognosis good outcome after resection. There evidence suggest that widespread pathology, leading atrophy, may associated such abnormal tissue play important role epileptogenesis. We have analysed quantitatively volumes lateral substructures from 62...
In patients with medically refractory focal epilepsy who are candidates for surgery, concordant non-invasive neuroimaging data useful to guide invasive electroencephalographic recordings or surgical resection. Simultaneous electroencephalography and functional magnetic resonance imaging can reveal regions of haemodynamic fluctuations related epileptic activity help localize its generators. However, many these studies (40–70%) remain inconclusive, principally due the absence interictal...
The segmentation from MRI of macroscopically ill-defined and highly variable structures, such as the hippocampus (Hc) amygdala (Am), requires use specific constraints. Here, we describe evaluate a fast fully automatic hybrid that uses knowledge derived probabilistic atlases anatomical landmarks, adapted semi-automatic method. algorithm was designed at outset for application on images healthy subjects patients with hippocampal sclerosis. Probabilistic were built 16 subjects, registered using...
Our aim was to investigate the presence of brain gray matter (GM) abnormalities in patients with different forms essential tremor (ET).We used optimized voxel-based morphometry (VBM) and manually traced single region-of-interest analysis 50 familial ET 32 healthy subjects. Thirty had arms (a-ET), whereas remaining 20 both arm head (h-ET).VBM showed marked atrophy cerebellar vermis h-ET respect subjects (P(corrected) < .001). Patients a-ET a trend toward vermal GM volume loss that did not...
Epileptic encephalopathy with continuous spikes and waves during slow sleep is an age-related disorder characterized by the presence of interictal epileptiform discharges at least >85% cognitive deficits associated this electroencephalography pattern. The pathophysiological mechanisms neuropsychological condition are still poorly understood. Here, we investigated haemodynamic changes epileptic activity using simultaneous acquisitions functional magnetic resonance imaging in 12 children...
Generalised spike wave (GSW) discharges are the electroencephalographic (EEG) hallmark of absence seizures, clinically characterised by a transitory interruption ongoing activities and impaired consciousness, occurring during states reduced awareness. Several theories have been proposed to explain pathophysiology GSW role thalamus cortex as generators. In this work we extend existing hypothesizing for precuneus, brain region neglected in previous works on generation but already known be...
<h3>Background</h3> The main challenge in assessing patients with epilepsy for resective surgery is localising seizure onset. Frequently, identification of the irritative and onset zones requires invasive EEG. EEG correlated functional MRI (EEG-fMRI) a novel imaging technique which may provide information regard to these regions. In focal epilepsy, interictal epileptiform discharge (IED) blood oxygen dependent level (BOLD) signal changes were observed approximately 50% whom IEDs are...