A5047747446- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Advanced Neuroimaging Techniques and Applications
- Personality Disorders and Psychopathology
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Fetal and Pediatric Neurological Disorders
- Psychosomatic Disorders and Their Treatments
- Face Recognition and Perception
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Neonatal and fetal brain pathology
- Autoimmune Neurological Disorders and Treatments
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Hemispheric Asymmetry in Neuroscience
- Cerebrospinal fluid and hydrocephalus
- Advanced NMR Techniques and Applications
- Mental Health and Psychiatry
- Attention Deficit Hyperactivity Disorder
Bielefeld University
2019-2025
Evangelisches Krankenhaus Bielefeld
2014-2025
Krankenhaus Mara
2015-2024
Klinikum Vest
2023
Laboratory Krone
2023
Bethel University
2007-2023
Klinikum Bielefeld
2003-2023
University of Zurich
2023
Meyer Children's Hospital
2022
University of Florence
2022
Comparing the determination of language dominance using fMRI with results Wada test in 100 patients different localization-related epilepsies, authors found 91% concordance between both tests. The overall rate false categorization by was 9%, ranging from 3% left-sided temporal lobe epilepsy (TLE) to 25% extratemporal epilepsy. Language might reduce necessity for lateralization, especially TLE.
MRI scans of patients with idiopathic generalized epilepsy (IGE) are normal on visual assessment. Using an interactive anatomical segmentation technique and volume-of-interest measurements MRI, we showed recently that IGE had significantly larger cortical grey matter than control subjects. Further, 40% individual juvenile myoclonic (JME), a syndrome in adolescence, significant abnormalities cerebral structure. In this study, applied the automated objective statistical parametric mapping...
EEG-triggered functional MRI (fMRI) offers the potential to localize generators of scalp EEG events, such as interictal epileptiform discharges, using a biological measurement opposed relying solely on modelling techniques. Although recent studies have demonstrated these possibilities in small number patients, wider application has been limited by concerns about patient safety, severe problems due pulse-related artefact obscuring trace, and lack reproducibility data. We systematically...
Recurrent episodes with interictal affective aggression are a rare but well-recognized problem in patients temporal lobe epilepsy. They referred to as episodic dyscontrol or, more precisely, intermittent explosive disorder (IED). The amygdala play crucial role the evaluation of multimodal sensory input and neurobiological mediation aggressive behaviour. With hippocampal sclerosis, context mesial being most common cause epilepsy, we hypothesized that might be affected by same pathogenic...
<h3>Background</h3> Two novel antibodies (abs) directed to γ-aminobutyric acid B receptor (GABA<sub>B</sub>R) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPAR) in patients with limbic encephalitis (LE) were first described by the Philadelphia/Barcelona groups confirmed Mayo group. We present a series for further clinical paraclinical refinement. <h3>Methods</h3> Serum cerebrospinal fluid samples from diagnostic laboratory selected if found be positive GABA<sub>B</sub>R or AMPAR abs...
The histopathological spectrum of human epileptogenic brain lesions is widespread including common and rare variants cortical malformations. However, 2-26% epilepsy surgery specimens are histopathologically classified as nonlesional. We hypothesized that these include also new diagnostic entities, in particular when presurgical magnetic resonance imaging (MRI) can identify abnormal signal intensities within the anatomical region seizure onset. In our series 1381 en bloc resected specimens,...
<h3>Importance</h3> A functional area associated with the piriform cortex, termed<i>area tempestas</i>, has been implicated in animal studies as having a crucial role modulating seizures, but similar evidence is limited humans. <h3>Objective</h3> To assess whether removal of cortex postoperative seizure freedom patients temporal lobe epilepsy (TLE) proof-of-concept for relevance this human TLE. <h3>Design, Setting, and Participants</h3> This cohort study used voxel-based morphometry...
Temporal lobe epilepsy (TLE) is one of the syndromes linked to antibodies against glutamic acid decarboxylase (GAD). It has been questioned whether 'limbic encephalitis with GAD antibodies' a meaningful diagnostic entity. The immunopathogenesis GAD-TLE remained enigmatic. Improvement immunological treatability an urgent clinical concern. We retrospectively assessed clinical, MRI and CSF course as well brain tissue 15 adult patients who underwent temporal surgery. Brain was studied by means...
Zusammenfassung In der neuen S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ werden Empfehlungen zu klinisch relevanten Fragestellungen in fünf großen Themenblöcken gegeben: Management erster Anfall, Pharmakotherapie, Epilepsiechirurgie, komplementäre supportive Therapieverfahren psychosoziale Aspekte. Beim Thema Leitlinie zunächst zur Unterscheidung beiden maßgeblichen Differenzialdiagnosen, Synkope psychogener nicht-epileptischer gegeben. Zudem wird...
The dynamic integration of the lateralized and specialized capacities two cerebral hemispheres constitutes a hallmark feature human brain function. This inter-hemispheric exchange information is thought to critically depend upon corpus callosum. Classical anatomical descriptions callosal organization outline topographic gradient from front back, such that specific transcallosal fibers support distinct aspects integrated Here we present challenge this conventional model. Using neuroimaging...
The assessment of mesial temporal lobe (MTL) function is important for the diagnosis and treatment epilepsy (TLE) other brain diseases. Declarative memory depends on integrity MTL region.To investigate hemispheric asymmetries activity in patients with symptomatic TLE.With use blood oxygenation level-dependent fMRI, activation 30 individual refractory TLE 17 healthy control subjects were studied. Activation was induced by a task employing mental navigation recall landmarks based retrieval...
A new fast automated algorithm has been developed to segment the brain from T1-weighted volume MR images. The uses thresholding and morphological operations. It is fully three-dimensional therefore independent of scan orientation. validity performance were evaluated by comparing automatically calculated with semi-automated measurements in 10 subjects, calculating repeated scans another visual inspection. mean standard deviation difference between 0.56% 2.8% volume, respectively, which within...
Post-mortem and structural brain imaging studies in schizophrenia have reported macroscopic changes such as global regional cortical volume reductions, but it has been more difficult to characterize the histopathological that underlie these abnormalities. Magnetization transfer (MTI), a novel MRI technique, sensitive subtle or early neuropathological than conventional MRI, provides quantitative measure of macromolecular integrity represented by magnetization ratio (MTR). In this study, we...
The principal MRI features of hippocampal sclerosis are volume loss and increased T2 weighted signal intensity. Minor localised abnormalities may be overlooked without careful quantitation. Hippocampal relaxation time (HT2) can quantified, but previously has only been measured on a few thick coronal slices with interslice gaps. In this study HT2 was along the entire length hippocampus contiguous used, quantitative measures (HV) distribution atrophy, to better define range sclerosis.Thirty...
Abstract We examined the localization of cerebral functions in 28 patients with focal epilepsy and malformations cortical development (MCDs). Polymicrogyria occurred nine, hemimegalencephaly four, heterotopia eight, dysplasia (FCD) nine cases. used simple (sensomotor, visual) or complex (language, memory) functional magnetic resonance imaging (fMRI) paradigms. Two thirds MCDs were activated by fMRI paradigms, whereas they less frequently showed activity during cognitive During all...
Psychosis of epilepsy (POE) has been recognized as a severe complication chronic intractable for more than century. Most the clinical symptoms POE are reminiscent schizophrenia. Nevertheless, there is general agreement that phenomenology differs from classical The temporal lobe hypothesis schizophrenia put forward in 1960s notes episodes with paranoid psychoses prevalent (TLE). However, aetiology and pathogenesis poorly understood. One strongest biological findings volume loss structures...
Summary: Purpose: Anterior temporal lobe resection (ATR) is a treatment option in drug‐resistant epilepsy. An important risk of ATR loss memory because mesiotemporal structures contribute substantially to function. We investigated whether memory‐activated functional MRI ( f MRI) can predict postoperative after anterior lobectomy right‐sided medial epilepsy (MTLE). Methods: included 16 patients (10 women) aged 16–54 years. The mean age at onset was 12.5 years (range, 1–26 years). patients'...
In patients with idiopathic generalized epilepsy (IGE), visual inspection of routine MRI is normal. However, pathological studies have shown microdysgenesis in grey and white matter a large percentage autopsies from cases IGE. Recently, widespread structural changes not evident on high resolution been using quantitative apparently focal cerebral dysgenesis. We sought to determine whether similar might be present IGE, reflecting possible underlying abnormalities. Twenty juvenile myoclonic...
Quantitative analysis of 1H-magnetic resonance spectroscopic imaging (MRSI) data was developed using the user-independent spectral routine LCModel. Tissue segmentation performed statistical parametric mapping software (SPM 96), and results were used to correct for cerebrospinal fluid contamination. A correction imperfections in excitation profile order improve uniformity metabolite images. After validation phantoms, these techniques applied study differences concentrations between gray white...