A5077405107- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Neurological Complications and Syndromes
- Barrier Structure and Function Studies
- Advanced Glycation End Products research
- Telomeres, Telomerase, and Senescence
- Mesenchymal stem cell research
- Vascular Malformations Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Intracerebral and Subarachnoid Hemorrhage Research
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular anomalies and interventions
- RNA regulation and disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aortic Disease and Treatment Approaches
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
University of Nottingham
2021-2025
Queen's Medical Centre
2021-2024
Chinese Institute for Brain Research
2017-2021
Capital Medical University
2017-2021
National Clinical Research Center for Digestive Diseases
2018-2020
Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI) encountered, particularly amongst elderly patients with clinical scenarios, such as age-related arteriosclerotic vascular disease, heart surgery and organ transplantation, is still an unsettled conundrum that besets clinicians.Remote ischemic conditioning (RIC), delivered via transient, repetitive noninvasive IR interventions to distant organs or tissues, regarded innovative approach against IRI.Based on...
Breakdown of blood-brain barrier (BBB) represents a key pathology in hyperglycemia-mediated cerebrovascular damage after an ischemic stroke. As changes the level and nature vasoactive agents released by endothelial cells (ECs) may contribute to BBB dysfunction, this study first explored specific impact hyperglycemia on EC characteristics secretome. It then assessed whether secretome obtained from ECs subjected normoglycaemia or might regulate pericytic cytokine profile differently. Using...
Accumulation of senescent cells in cerebrovasculature is thought to play an important role age-related disruption blood–brain barrier (BBB). Using vitro model human BBB, composed brain microvascular endothelial (BMECs), astrocytes and pericytes, this study explored the so-called correlative link between BMEC senescence BBB dysfunction absence or presence functionally distinct senotherapeutics. Replicative was deemed present at passage ≥19 where BMECs displayed shortened telomere length,...
Oxidative stress is a prominent causal factor in the premature senescence of microvascular endothelial cells and ensuing blood-brain barrier (BBB) dysfunction. Through exposure an vitro model human BBB, composed brain (BMECs), astrocytes, pericytes to H
Abstract Recently, internal jugular vein stenosis (IJVS) is gaining increasing attention from clinical researchers due to a series of confounding symptoms that impair the quality life in affected individuals but cannot be explained by other well-established causes. In this study, we aimed elucidate features, neuroimaging characteristics and pathogenesis IJVS, explore their possible correlations, attempt provide useful clues for diagnosis treatment. Forty-three eligible patients with...
Abstract Aims This study aimed to identify the clinical profiles of cervical spondylosis‐related internal jugular vein stenosis (IJVS) comprehensively. Methods A total 46 patients, who were diagnosed as IJVS induced by spondylotic compression recruited. The manifestations and imaging features presented particularly in this study. Results Vascular was present 69 out 92 veins, which, 50.7% (35/69) stenotic vessels compressed transverse process C1, 44.9% (31/69) C1 combined with styloid...
Distinguishing moyamoya disease (MMD) from intracranial atherosclerotic stenosis (IAS) is critical for its treatment and outcome evaluation. This study aimed to use the combined sequences of high-resolution magnetic resonance imaging (HRMRI) arterial spin labeling MR (ASL-MR) identify two entities accurately.This prospective enrolled 58 patients with middle cerebral artery (MCA) steno-occlusion identified by digital subtraction angiography (DSA), including 27 cases MMD 31 IAS. All underwent...
Our previous study revealed that remote ischemic conditioning (RIC) reduced the incidence of stroke or TIA in octo- and nonagenarians with intracranial atherosclerotic stenosis (ICAS). Herein, we aimed to investigate whether RIC would influence progression white matter hyperintensities (WMHs) cognitive impairment same group patients. Fifty-eight patients ICAS were randomly assigned a 1:1 ratio receive standard medical treatment (n=30) versus sham-RIC (n=28). The protocol consisted 5 cycles...
Background: The transition to dolutegravir-containing antiretroviral therapy (ART) in low- and middle-income countries (LMICs) was complicated by an initial safety signal May 2018 suggesting that exposure dolutegravir at conception possibly associated with infant neural tube defects. On the basis of additional evidence, July 2019, World Health Organization recommended for all adults adolescents living HIV. Objective: To describe uptake disparities sex age group LMICs. Design: Observational...
Accumulation of senescent endothelial cells (ECs) in vasculature represents a key step the development vascular aging and ensuing age-related diseases. Given that removal ECs may prevent disease improve health wellbeing, discovery novel biomarkers effectively identify is particular importance. As crucial elements for biological pathways reliable bioindicators cellular processes, metabolites demand attention this context. Using human brain microvascular (HBMECs) displaying secretory phenotype...
Summary Aims The objective of this study was to evaluate cerebral venous recanalization with magnetic resonance black‐blood thrombus imaging (MRBTI) in patients thrombosis (CVT) who underwent batroxobin treatment combination anticoagulation. Methods A total 31 CVT were enrolled real‐world registry study. divided into (n = 21) and control groups 10). In addition the same standard anticoagulation as group, group intravenous for a three times. Results compared we found better odds degree...
<b><i>Background:</i></b> Visual damage is one of the most common complications cerebral venous sinus thrombosis (CVST)-associated intracranial hypertension (IH). This study aimed at stratifying risk IH-induced visual in an attempt to predict its deterioration and prevent high-risk patients from irreversible eyesight impairment promptly. <b><i>Methods:</i></b> A total 94 with confirmed diagnosis CVST were eligible for enrollment this study....
Chronic cerebral circulation insufficiency (CCCI) is viewed as an alarming state induced by long-term reduction in perfusion, which associated with neurological deficits and high risk of stroke occurrence or recurrence. CCCI accounts for a large proportion both outpatients inpatients cerebrovascular diseases, while management remains formidable challenge to clinicians. Normobaric oxygen (NBO) adjuvant hyperoxygenation intervention supplied one atmosphere pressure (1 ATA =101.325 kPa). A...