A5013117074- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Infectious Diseases and Tuberculosis
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Urological Disorders and Treatments
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reproductive Health and Contraception
- Hepatitis C virus research
- Animal Virus Infections Studies
- Lipoproteins and Cardiovascular Health
- RNA Interference and Gene Delivery
HIV Netherlands Australia Thailand Research Collaboration
2017-2025
Chulalongkorn University
2019-2024
Thai Red Cross Society
2019-2024
Amsterdam Institute for Global Health and Development
2023
Amsterdam University Medical Centers
2023
University of Amsterdam
2023
ChiangRai Prachanukroh Hospital
2020
Children's Hospital 1
2020
Siriraj Hospital
2020
Mahidol University
2020
Immune restoration is often incomplete after ART in HIV patients, both quantitatively and qualitatively. We studied the incidence probability of CD4/CD8 normalization an adult Thai cohort explored predictive value ratio for developing non-AIDS defining events (NAEs).We analyzed data from HIV-infected adults between 1996 2017 HIV-NAT 006 prospective long-term Bangkok, Thailand. Normalization was defined as ≥ 1 on two consecutive visits, calculated using Kaplan-Meier method. NAEs were a...
To evaluate the applicability and accuracy of urine lipoarabinomannan (LAM) test in tuberculosis (TB)/HIV co-infected patients HIV-negative with disseminated TB.Frozen samples obtained at baseline from TB research cohort proven culture-positive were selected for blinded LAM testing. One hundred nine categorized into four groups: (1) HIV-positive TB; (2) (3) immunocompromised (4) diseases other than TB. The sensitivity testing TB, specificity without positive predictive value (PPV), negative...
Abstract Background We investigated the association between nonalcoholic fatty liver disease (NAFLD) plus or minus a concurrent diagnosis of steatohepatitis (NASH) and incident diabetes mellitus (DM) risk factors associated with NAFLD NASH development. Methods In this prospective study, we analyzed people human immunodeficiency virus (HIV; PWH) aged ≥18 years without excessive alcohol consumption hepatitis coinfections. was defined as controlled attenuation parameter ≥248 dB/m, whereas...
Abstract Background Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection is associated with metabolic changes, including dyslipidemia and cardiovascular risk. Switching from protease inhibitor (PIs)-based regimens to dolutegravir (DTG)-based offers potential benefits, but its impact on parameters requires investigation. This study aimed assess the change in low-density lipoprotein cholesterol (LDL-C) levels, a risk factor disease, people living HIV (PLWH) who...
To determine the incidence and risk factors for developing diabetes mellitus in a cohort of Thai HIV-infected patients on long-term combination antiretroviral therapy (cART).Prospective study conducted between July 1996 30 April 2015.A total 1748 (60% men) who did not have prior to ART were assessed twice year. Incident was defined as either having two consecutive fasting glucose levels more than 126 mg/dl, or reporting antidiabetes medication/diabetes diagnosis after starting cART....
Abstract ChulaCov19 mRNA vaccine demonstrated promising phase 1 results. Healthy adults aged 18–59 years were double-blind randomised 4:1 to receive two intramuscular doses of 50 µg or placebo. Primary endpoints safety and microneutralization antibody against-wild-type (Micro-VNT50) at day 50. One hundred fifty with median (IQR) age 37 (30–46) randomised. was well tolerated, most adverse events mild moderate temporary. Geometric mean titres (GMT) neutralizing titre against wild-type for on...
Abstract Background Prisons are considered as major reservoirs for tuberculosis. Preventive therapy latent TB infection (LTBI) is an adjunctive strategy to control TB. However, LTBI data in Thai prisoners limited. This study assessed the prevalence of and feasibility isoniazid preventive (IPT). Methods A cross-sectional was conducted among Klong Prem Central Prison, Bangkok. Participants were screened active by questionnaire chest X-ray. evaluated Tuberculin skin test (TST) QuantiFERON-TB...
ObjectivesTo determine if double-dose levonorgestrel emergency contraception (EC) in combination with efavirenz or rifampicin, 2 drugs known to decrease exposure, resulted similar pharmacokinetics compared standard-dose EC without drug-drug interactions.Study DesignWe conducted a phase 2, open-label, multicenter, partially randomized, 4 parallel group trial pre-menopausal females ≥16 years old an indication for and not on hormonal contraception. Participants dolutegravir-based antiretroviral...
Background: The transition to dolutegravir-containing antiretroviral therapy (ART) in low- and middle-income countries (LMICs) was complicated by an initial safety signal May 2018 suggesting that exposure dolutegravir at conception possibly associated with infant neural tube defects. On the basis of additional evidence, July 2019, World Health Organization recommended for all adults adolescents living HIV. Objective: To describe uptake disparities sex age group LMICs. Design: Observational...
Abstract Introduction Among high tuberculosis (TB) and HIV burden countries in Asia, preventive therapy (TPT) people living with (PLWH) has been underutilized despite its proven benefits independent of antiretroviral (ART). Therefore, we determined the incidence active TB mortality among 9179 adult PLWH who attended received ART from 15 tertiary care hospitals across Thailand. Methods A retrospective study was conducted 2018 using follow‐up data 1999 to 2018. The primary endpoint incident...
Abstract Background Non-sputum-based tests are needed to predict or diagnose tuberculosis (TB) disease in people living with HIV (PWH). The enzyme indoleamine 2, 3-dioxygenase-1 (IDO1) is expressed tuberculoid granuloma and catabolizes tryptophan (Trp) kynurenine (Kyn). IDO1 activity compromises innate adaptive immune responses, promoting mycobacterial survival. plasma Kyn-to-Trp (K/T) ratio a potential TB diagnostic and/or predictive biomarker PWH on long-term antiretroviral therapy (ART)....
The Phase 3 randomized controlled trial, TBTC Study 31/ACTG A5349 (NCT02410772) demonstrated that a 4-month rifapentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. primary efficacy outcome 12-month disease free survival, while the safety proportion of grade or higher adverse events during treatment period. We conducted an analysis demographic, clinical, microbiologic, radiographic, pharmacokinetic data identified risk factors unfavorable outcomes...
ObjectiveTo assess the efficacy and safety of a new single-tablet regimen (STR) tenofovir disoproxil fumarate (TDF) 300 mg, lamivudine (3TC) efavirenz (EFV) 600 mg in HIV-infected Thai patients.MethodsThis was prospective study performed for 144 weeks among 51 treatment-naïve patients 49 experienced on separate tablets TDF, 3TC, EFV with HIV RNA<50 copies/ml. CD4, RNA, liver renal function, lipid profiles were assessed at baseline, 12, 24, 48, then every 24 weeks.ResultsThe median baseline...
Infection with high-risk human papillomavirus (HR-HPV) may be higher in perinatally immunodeficiency virus (HIV)-infected (PHIV) than HIV-uninfected (HU) adolescents because of long-standing immune deficiency.PHIV and HU females aged 12-24 years Thailand Vietnam were matched by age group lifetime sexual partners. At enrollment, blood, cervical, vaginal, anal, oral samples obtained for HPV-related testing. The Wilcoxon Fisher exact tests used univariate logistic regression multivariate...
BACKGROUND: Diagnostic tools to identify incipient or subclinical TB stages will be helpful for preventive intervention. A simple biomarker predict may the monocytes lymphocytes ratio (ML ratio) in peripheral blood. METHODS: We assessed relationship between multiple time-updated ML measurements and incidence of people living with HIV (PLWH) after antiretroviral therapy (ART) was initiated. The updated at least every 6 months. corresponding 95% confidence intervals stratified according...
Abstract Background Aging characteristics in people living with HIV (PLWH) are heterogeneous, and the identification of risk factors associated aging-related comorbidities such as neurocognitive impairment (NCI) frailty is important. We evaluated predictors novel aging markers, phenotypic age (PhenoAge) acceleration (PAA) their association comorbidities, frailty, NCI. Methods In a cohort PLWH age- sex-matched HIV-negative controls, we calculated PhenoAge using chronological 9 biomarkers from...
BIT225 is a first-in-class inhibitor of human immunodeficiency virus (HIV) type 1 Vpu. A phase II trial enrolled 36 HIV-1-infected, treatment-naive participants in Thailand to receive standard-of-care antiretroviral therapy (ART), tenofovir disoproxil fumarate/emtricitabine/efavirenz (Atripla), with 100 or 200 mg placebo (daily) for 12 weeks. Combined treatment and ART was found be generally safe well tolerated, antiviral efficacy comparable that alone. The secondary end point-soluble CD163,...
Abstract Background Antiretroviral therapy (ART) is known to reduce tuberculosis (TB) incidence among people living with HIV (PLWH). However, studies describing the impact of long-term ART and CD4 count recovery on TB remain scarce due limited follow up in previous studies. We evaluated a cohort PLWH Thailand. Methods conducted an analysis aged ≥ 18 years who started between 1996 December 2020. Participants were followed every 6 months for routine care. risk factors, body mass index (BMI),...
Abstract Introduction Immune dysregulation persists in people with HIV (PWH) on antiretroviral therapy (ART) and may lead to accelerated vascular ageing cardiovascular disease (CVD). While delayed time initiation of ART has been linked worse outcomes, the effect during acute infection these outcomes is not well understood. Methods Participants were enrolled from SEARCH010/RV254 (AHI) HIV‐NAT chronic (CHI) cohorts Thailand. 6‐year follow‐up viral suppression (viral load < 50 copies/μL) at...