A5074824322- Burkholderia infections and melioidosis
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Diagnosis and Treatment of Venous Diseases
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Brucella: diagnosis, epidemiology, treatment
- Infectious Diseases and Mycology
- Nosocomial Infections in ICU
- Myxozoan Parasites in Aquatic Species
- Vibrio bacteria research studies
- Subcritical and Supercritical Water Processes
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Salmonella and Campylobacter epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Moringa oleifera research and applications
- Patient Satisfaction in Healthcare
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Clinical practice guidelines implementation
- Amoebic Infections and Treatments
- Acute Ischemic Stroke Management
Surin Hospital
2019-2025
Technical University of Munich
2019
Melioidosis is a neglected tropical infection caused by the environmental saprophyte Burkholderia pseudomallei.We conducted prospective, observational study at nine hospitals in northeastern Thailand, hyperendemic melioidosis zone, to define current characteristics of patients and quantify outcomes over one year.2574 individuals hospitalised with culture-confirmed were screened 1352 analysed. The median age was 55 years, 975 (72%) male, 951 (70%) had diabetes. 565 (42%) presented lung...
Abstract Background Vascular pythiosis, caused by Pythium insidiosum, is a life-threatening disease with high mortality rate in patients residual post-surgery. This study evaluated the effectiveness of combination therapy surgery, azithromycin, doxycycline, and itraconazole. Methods In this open-label, Phase II multicenter trial, 51 were enrolled. Patients categorized based on post-surgery (unresectable lesions, incomplete resection, or persistent symptoms). received azithromycin (500 mg...
Abstract Nontyphoidal Salmonella , an important zoonotic pathogen and a major cause of foodborne illnesses, could be potential reservoir plasmids harbouring mobile colistin resistance gene ( mcr ). This study reported, for the first time, high rate -carrying clinical isolates (3.3%, 24/724) in Thailand, associated with mcr-3 (3.0%, 22/724) S. 4,[5],12:i:-(15.4%, 4/26), S . Typhimurium (8.8%, 5/57), Choleraesuis (5.6%, 13/231). Remarkably, increasing trends extended-spectrum cephalosporin...
Melioidosis is an often fatal infection in tropical regions caused by environmental bacterium, Burkholderia pseudomallei . Current recommended melioidosis treatment requires intravenous β-lactam antibiotics such as ceftazidime (CAZ), meropenem (MEM), or amoxicillin-clavulanic acid (AMC) and oral trimethoprim-sulfamethoxazole.
Abstract Introduction Among high tuberculosis (TB) and HIV burden countries in Asia, preventive therapy (TPT) people living with (PLWH) has been underutilized despite its proven benefits independent of antiretroviral (ART). Therefore, we determined the incidence active TB mortality among 9179 adult PLWH who attended received ART from 15 tertiary care hospitals across Thailand. Methods A retrospective study was conducted 2018 using follow‐up data 1999 to 2018. The primary endpoint incident...
: Melioidosis is an infectious disease caused by
Abstract The rapidly increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) over the past decade has increased concern in healthcare facilities and impact on public health. bla KPC (KPC) Thailand remains very low; only KPC-13 been described previously. This study is first to describe characteristics KPC-2 -carrying Klebsiella pneumoniae , Escherichia coli Enterobacter asburiae Thailand. rate isolates was 0.13% among CRE our study. Based carbapenem susceptibility testing, K....
Melioidosis is an often lethal tropical disease caused by the Gram-negative bacillus, Burkholderia pseudomallei. The study objective was to characterize transcriptomes in melioidosis patients and identify genes associated with outcome. Whole blood RNA-seq performed a discovery set of 29 3 healthy controls. Transcriptomic profiles who did not survive 28 days were compared survived controls, showing 65 significantly up-regulated 218 down-regulated non-survivors survivors. Up-regulated involved...
Abstract Although substantial progress has been made in the pathophysiology and management of post-thrombotic syndrome (PTS), several aspects still need clarification. Among them, incidence severity PTS real world, risk factors for its development, value patient’s self-evaluation, ability to identify patients at severe PTS. Eligible participants (n = 1107) with proximal deep-vein thrombosis (DVT) from global GARFIELD-VTE registry underwent conventional physician’s evaluation 36 months after...
The Global Antimicrobial Resistance Surveillance System (GLASS) is one of the pillars global action plan on antimicrobial resistance launched by World Health Organization in 2015. This study was conducted to determine feasibility and benefits GLASS as a component stewardship strategies three provincial hospitals Thailand. Data types bacteria isolated their antibiotic susceptibility during January-December 2019 January-April 2020 were retrieved from microbiology laboratory each participating...
A quasi-experimental study was conducted on the implementation of locally developed clinical practice guidelines (CPGs) for empirical antibiotic (ATB) therapy common infections (bacteremia, urinary tract infection (UTI), pneumonia) in hospitals from January 2019 to December 2020. The CPGs were using data patients with these at individual hospitals. Relevant CPG pre- and post-implementation collected compared. Of 1644 enrolled study, 808 836 periods, respectively, patient outcomes Significant...
ABSTRACT. Melioidosis, infection caused by Burkholderia pseudomallei , is characterized robust innate immune responses. We have previously reported associations of TLR1 single nucleotide missense variant rs76600635 with mortality and TLR5 nonsense rs5744168 both bacteremia in single-center studies patients melioidosis northeastern Thailand. The objective this study was to externally validate the a large multicenter cohort patients. genotyped 1,338 enrolled prospective parent conducted at...
Background: Melioidosis, a disease induced by Burkholderia pseudomallei, poses significant health threat in tropical areas where it is endemic. Despite the availability of effective treatments, mortality rates remain notably elevated. Many risk factors are associated with mortality. This study aims to develop scoring system for predicting in-hospital from melioidosis using readily available clinical data. Methods: The data were collected Surin Hospital, Surin, Thailand, during period April...
Abstract Background Vascular pythiosis, caused by Pythium insidiosum, is a neglected, life-threatening condition which carried 100% mortality rate, within 3 months, among patients with residual disease after surgery, regardless of antifungal treatment. Recently, Thai P. insidiosum isolates were found to susceptible doxycycline and azithromycin, evidence synergy. We report results clinical trial from 15 centers in Thailand (Thai Clinical Trial Registry number TCTR20191217006). Methods This...
Implementing antimicrobial stewardship (AMS) at non-university hospitals is challenging. A quasi-experimental study was conducted to determine the impact of customised antibiotic authorisation implementation on consumption and clinical outcomes three provincial in Thailand. Customised pre-authorisation selected restricted antibiotics post-authorisation controlled were undertaken implemented each hospital by local AMS team with guidance from university hospital. From January 2019−December...
Rationale: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) use is associated with a lower risk of incident pneumonia and, less robustly, nonpulmonary infections. Whether statin than other clinical presentations infection the same pathogen unknown. Objectives: To assess whether preadmission nonpneumonia among patients hospitalized Burkholderia pseudomallei (melioidosis). Methods: We performed secondary analysis prospective multicenter cohort study culture-confirmed B. used...