A5044002687- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Bacteriophages and microbial interactions
- Medical Device Sterilization and Disinfection
- Vibrio bacteria research studies
- Ocular Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Dialysis and Renal Disease Management
- Antimicrobial Peptides and Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 detection and testing
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Antifungal resistance and susceptibility
- Salmonella and Campylobacter epidemiology
- Reproductive tract infections research
- Streptococcal Infections and Treatments
- Dermatology and Skin Diseases
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Biosensors and Analytical Detection
Chulalongkorn University
2016-2025
King Chulalongkorn Memorial Hospital
2019-2025
Thai Red Cross Society
2021-2025
Princess Margaret Hospital for Children
2022
Perth Children's Hospital
2022
Bangkok University
2022
University of Florida
2019
Columbus Oncology and Hematology Associates
2019
Queen Sirikit National Institute of Child Health
2014
Faculty (United Kingdom)
2013
Abstract Tigecycline has been regarded as one of the most important last-resort antibiotics for treatment infections caused by extensively drug-resistant (XDR) bacteria, particularly carbapenem- and colistin-resistant Klebsiella pneumoniae (C-C-RKP). However, reports on tigecycline resistance have growing. Overall, ~ 4000 K. clinical isolates were collected over a five-year period (2017–2021), in which 240 C-C-RKP investigated. Most these (91.7%) resistant to tigecycline. Notably, high-risk...
The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with colistin usage for treating carbapenem-resistant K. (CRkp). Our study demonstrated the rising trend ColRkp showing extensively pandrug-resistant characteristics among CRkp, a 28.5%, which was mediated mgrB, pmrB, phoQ mutations (91.5%), mcr-1.1, mcr-8.1, mcr-8.2 alone in conjunction R256G PmrB (8.5%)....
Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials studied combinations these agents. The aim this trial was to assess effectiveness affordable, widely available, repurposed used combination for which may be particularly relevant low-resource countries.
Stevens - Johnson syndrome (SJS) has manifestation through the exfoliation of epidermis and mucosal tissue. Ocular surface is usually affected in acute chronic stage. The patients are suffered from ocular sequelae including symblepharon, limbal stem cell deficiency, etc. Furthermore, microbiome may also be altered SJS. This prospective, age sex matched analytical study which 20 SJS healthy subjects for specimen collection inferior conjunctiva analysis by conventional cultures Next-Generation...
Overcoming colistin-resistant Acinetobacter baumannii (CoR-AB) has become a major concern due to the lack of effective antibiotics. This study aimed explore prevalence CoR-AB clinical isolates in Thailand, their mechanisms resistance, and test efficacy colistin plus sulbactam against isolates. The resistance rate among carbapenem-resistant A. was 15.14%. mcr gene or its variants were not detected by PCR screening. lipid A mass spectra showed additional [M-H]- ion peak at m/z = 2034 that...
The monkeypox virus is excreted in the feces of infected individuals. Therefore, there an interest using viral load detection wastewater for sentinel early surveillance at a community level and as complementary approach to syndromic surveillance. We collected from 63 sewered non-sewered locations Bangkok city center between May August 2022. Monkeypox DNA copy numbers were quantified real-time polymerase chain reaction (PCR) confirmed positive by Sanger sequencing. was first detected second...
Abstract Cutibacterium acnes is associated with the pathogenesis of acne vulgaris (AV). The relationship between antibiotic‐resistant C. and AV remains unclear. authors aimed to determine prevalence investigate association severity topical systemic treatments in patients acne. Samples were collected inflammatory noninflammatory acne, including closed open comedones erythematous papules/pustules from face mild severe samples cultured under anaerobic conditions for isolation . Antibiotic...
Discover the shifting landscape of SARS-CoV-2 variants from October to December 2023, with JN.1 dominating South and Southeast Asia wastewater samples, increasing <10% >90%. Experience dynamic evolution viral strains in this period.
is a common pathogen associated with hospital-acquired pneumonia showing increased resistance to carbapenem and colistin antibiotics nowadays. Infections
SARS-CoV-2 RNA is excreted in feces of most patients, therefore viral load wastewater can be used as a surveillance tool to develop an early warning system help and manage future pandemics.
Abstract Development of an effective therapy to overcome colistin resistance in Klebsiella pneumoniae , a common pathogen causing catheter-related biofilm infections vascular catheters, has become serious therapeutic challenge that must be addressed urgently. Although and EDTA have successful roles for eradicating biofilms, no vitro vivo studies investigated their efficacy colistin-resistant K. . In this study, was significantly reversed both planktonic mature biofilms by combination (0.25–1...
Some multidrug-resistant gram-negative bacteria as a global threat have been recently prioritized for research and development of new treatments. We studied the efficacy methylene blue-mediated antimicrobial photodynamic therapy (MB-aPDT) reduction extensively drug-resistant Acinetobacter baumannii (XDR-AB) Pseudomonas aeruginosa (XDR-PS) Klebsiella pneumoniae (MDR-KP) isolated in university hospital setting Thailand.Two isolates each selected bacterium were collected, XDR-AB1 AB2, XDR- PS1...
High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance six Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians helps allocate resources like testing, vaccines therapeutics resource-limited countries.
Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam or ceftazidime-avibactam in vitro and vivo against diverse CPKp clinical isolates. The synergy testing of this study demonstrated novel aztreonam-Ca-EDTA ceftazidime-avibactam-Ca-EDTA was significantly eliminating planktonic mature biofilms vitro, as well eradicating...
The study explored SARS-CoV-2 viral concentrations in the dust as a surveillance tool Lockdown reduced concentrations, curbing spread Viral levels dropped public areas but transmission persisted Our results provide another non-invasive avenue for monitoring COVID-19 outbreaks
Background and aim: Gardenia jasminoides (G. jasminoides) could treat various inflammatory diseases. This study aimed to investigate the effects of G. fruit extract on gastric inflammation protective mechanisms in Helicobacter pylori (H. pylori)-induced gastritis. Experimental procedure: was prepared analyzed for geniposide content. The inhibitory effect H. growth investigated using disk diffusion method. vitro anti-inflammatory property evaluated erythrocyte membrane stabilization...
Abstract Background Nanopore sequencing enables rapid DNA/RNA analysis without amplification. Implementing this for point-of-care diagnostics reduces time delays in traditional AST methods, potentially enhancing patient outcomes. We aim to evaluate the performance of Oxford Technologies from positive blood culture bacterial identification and antimicrobial susceptibility prediction S. aureus epidermidis by detecting mecA gene. Methods conducted a cross-sectional descriptive study on...
Pseudomonas aeruginosa infections in the lungs affect millions of children and adults worldwide. To our knowledge, no clinically validated prognostic biomarkers for chronic pulmonary P. exist. Therefore, this study aims to identify potential markers biofilm lung infections. Here, we screened expression 11 regulatory genes (tesG, algD, lasR, lasA, lasB, pelB, phzF, rhlA, rsmY, rsmZ, sagS) associations between clinical status infection. RNA was extracted from 210 sputum samples patients (n =...
Purpose Endophthalmitis is a serious eye infection that can occur after intravitreal injections. Topical antibiotics are frequently used as preventative measure, but their impact on the conjunctival microbiome not fully understood. Methods Conjunctival swabs were collected from 33 eyes of patients undergoing injections, both before and 3-day course prophylactic topical levofloxacin 0.5%. analysis was conducted using 16S rRNA sequencing Illumina MiSeq platform. Bioinformatics processing...
Abstract Despite strengthened antimicrobial therapy, biofilm infections of Acinetobacter baumannii are associated with poor prognosis and limited therapeutic options. Assessing antibiotics on planktonic bacteria can result in failure against infections. Currently, to treat administered empirically, usually without considering the susceptibility objectively before beginning treatment. For effective therapy resolve it is essential assess efficacy commonly used biofilms. Here, we offer a robust...
Abstract The global rapid emergence of azithromycin/ceftriaxone resistant Neisseria gonorrhoeae threatens current recommend dual therapy for gonorrhea to ensure effective treatment. Here, we identified the first two N. isolates with decreased ceftriaxone susceptibility in Thailand. Among 134 collected from Thai Red Cross Anonymous Clinic, Bangkok, (NG-083 and NG-091) urethral swab male heterosexual patients had reduced (MICs 0.125 mg/L). Both were multidrug strong biofilm producers tolerance...