A5081329640- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Vagus Nerve Stimulation Research
- Malaria Research and Control
- COVID-19 epidemiological studies
- Infectious Diseases and Tuberculosis
- Pregnancy and Medication Impact
- Hepatitis C virus research
- Sex work and related issues
- Nicotinic Acetylcholine Receptors Study
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Histiocytic Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
National Institute of Allergy and Infectious Diseases
2020-2024
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2015-2024
National Institutes of Health
2020-2024
NIMS University
2019-2024
Cambridge Information Group
2022
Gheskio Centers
2019
Vanderbilt University
2019
Fundacion Arriarán
2019
University of Chile
2019
Instituto Evandro Chagas
2019
Hospital length-of-Stay has been traditionally used as a surrogate to evaluate healthcare efficiency, well hospital resource utilization. Prolonged Length-of-stay (PLOS) is associated with increased mortality and other poor outcomes. Additionally, these patients represent significant economic problem on public health systems their families. We sought describe compare characteristics of Normal Length-of-Stay (NLOS) PLOS identify sociodemographic disease-specific factors in tertiary care...
To evaluate the prevalence of late HIV diagnosis (CD4<200 cell/mm³) in an clinic Mexico City between 2001-2008, to assess changes this across study period, and determine risk factors associated testing (LT).Cross-sectional analysis including all patients recently diagnosed as HIV. We estimated proportion LT compared demographic characteristics those other. using logistic regression methods.Sixty one percent present when are for first time. The did not decrease 2001 2008 (p=0.37). Older age...
Abstract Zika virus (ZIKV) outbreak in Americas led to extensive efforts develop vaccines and ZIKV-specific diagnostics. In the current study, we use whole genome phage display library spanning entire ZIKV (ZIKV-GFPDL) for in-depth immune profiling of IgG IgM antibody repertoires serum urine longitudinal samples from individuals acutely infected with ZIKV. We observe a very diverse repertoire encompassing polyprotein on day 0 both urine. antibodies increase 10-fold between 7 serum, but not...
Abstract Background Semaglutide is highly effective for decreasing weight. Concomitant loss of muscle mass often accompanies weight and may have consequences on function. Methods This a secondary analysis from the SLIM LIVER (Advancing Clinical Therapeutics Globally HIV/AIDS Other Infections, ACTG A5371) study, single-arm study semaglutide in people with human immunodeficiency virus (HIV, PWH) metabolic dysfunction–associated steatotic liver diseases (MASLD). Participants received...
To compare the efficacy of efavirenz (EFV) vs lopinavir/ritonavir (LPV/r) in combination with azidothymidine/lamivudine antiretroviral therapy naive, HIV+ individuals presenting for care CD4 counts <200/mm.Prospective, randomized, open label, multicenter trial Mexico. HIV-infected subjects <200/mm were randomized to receive label EFV or LPV/r plus (fixed-dose combination) 48 weeks. Randomization was stratified by baseline cell count (< =100 >100/mm). The primary endpoint percentage patients...
To determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled a randomized, placebo-controlled ART initiation trial South Africa and Mexico to test whether maraviroc could prevent IRIS. Participants classified prospectively as having within 6 months of initiation. Twenty measured at study enrollment 267 participants....
Immune activation associated with HIV-1 infection contributes to morbidity and mortality. We studied whether chloroquine, through Toll-like receptor (TLR) antagonist properties, could reduce immune thought be driven by TLR ligands, such as gut-derived bacterial elements RNAs. AIDS Clinical Trials Group A5258 was a randomized, double-blind, placebo-controlled study in 33 HIV-1-infected participants off antiretroviral therapy (ART) 37 on ART. Study each cohort were randomized 1:1 receive...
Late presentation to care and antiretroviral therapy (ART) initiation with advanced human immunodeficiency virus (HIV) disease are common in Latin America. We estimated the impact of these conditions on mortality region. included adults enrolled during 2001-2014 at HIV clinics. adjusted attributable risk (AR) population fraction (PAF) for all-cause (advanced LP), ART disease, not initiating ART. Advanced was defined as CD4 <200 cells/μL or acquired immune deficiency syndrome. AR PAF were...
The population of aging adults living with human immunodeficiency virus (HIV) is growing worldwide and evidence suggests that frailty occurs prematurely among them. In turn, has been associated cognitive decline. It unknown, however, if people both HIV infection have a higher risk impairment compared nonfrail HIV-infected persons. Therefore, the main objective this study was to determine association between phenotype HIV-associated neurocognitive disorders (HAND) aged 50 years or older...
We studied the prevalence of HIV, syphilis, hepatitis B virus (HBV), and C (HCV) infection associated risk behaviors in prison state system Guanajuato, Mexico between September 2011 February 2012. Blood samples were drawn from adult inmates all State prisons who agreed to participate this cross-sectional study. Data on collected by using self-administered questionnaires. The HBV, HCV was 0.6% [95% confidence interval (CI) = 0.2–1.1], 0.7% (95% CI 0.4–1.0), 0.4 0.04–0.74), 4.8 3.6–5.9),...
To estimate the prevalence of HCV-infection and identify associated factors among inmates in State Prison System Guanajuato Mexico (Sep-2011 to Feb-2012).Cross-sectional, observational study 10 prisons (2011-2012). We offered HCV-testing applied audio computer-assisted self-interviews all adults imprisoned System. used a complex survey analysis distribution variables its corresponding 95% confidence intervals, taking into consideration expected cluster effect by common characteristics within...
ObjectivesTo determine if double-dose levonorgestrel emergency contraception (EC) in combination with efavirenz or rifampicin, 2 drugs known to decrease exposure, resulted similar pharmacokinetics compared standard-dose EC without drug-drug interactions.Study DesignWe conducted a phase 2, open-label, multicenter, partially randomized, 4 parallel group trial pre-menopausal females ≥16 years old an indication for and not on hormonal contraception. Participants dolutegravir-based antiretroviral...
To estimate the impact of immune reconstitution inflammatory syndrome (IRIS) on morbidity and mortality in patients starting highly-active antiretroviral therapy (HAART).A retrospective cohort study HIV-positive HAART was conducted at a tertiary care referral center Mexico City. We estimated incidence IRIS, hospitalizations death rates during first 2 years HAART. The relative risk (RR) hospitalization for with IRIS were adjusted relevant covariates using regression methods.During 2-year...
A growing population of older adults with HIV will increase demands on HIV-related healthcare. Nearly a quarter people receiving care for in Latin America are currently 50 years or older, yet little is known about the frequency comorbidities this population. We estimated prevalence and incidence non-communicable diseases (NCDs) among age (≥50yo) during 2000-2015 six centers affiliated Caribbean, Central South American network epidemiology (CCASAnet).We annual prevalence, overall...
People with HIV (PWH) are at increased risk of developing active tuberculosis (TB), and anemia is a common complication in both conditions. Anemia TB patients has been linked to immune activation, levels inflammatory biomarkers blood, for disease progression death. In this study we show that was associated more pronounced profile HIV-TB coinfected persons cohort 159 individuals advanced (CD4 count &lt; 100 cells/µL) recruited as part randomized clinical trial (NCT00988780). A panel...
The growing elderly population of HIV-infected patients is leading to a significant epidemiological transition and HIV infection has been proposed as premature accelerated aging model rending the individual more susceptible disability. However, determinants disability among this emergent are still lacking. Therefore, aim study determine correlates prevalent in adults ≥50 years with infection. A cross-sectional 184 receiving ambulatory care an clinic tertiary care, university-affiliated...
To determine the prevalence of adequate monitoring and costs measuring CD4+ T-lymphocytes (CD4+ cell) human immunodeficiency virus (HIV) viral load in people receiving antiretroviral therapy (ART) seven countries WHO Region Americas.We obtained retrospective, longitudinal data for 14 476 adults who started a first ART regimen at HIV clinics Argentina, Brazil, Chile, Haiti, Honduras, Mexico Peru between 2000 2011. We estimated proportion 180-day periods with monitoring, which we defined as...
Background The HIV care cascade has improved in Latin America over the last decade. However, influence of alcohol and noninjected drug use (NIDU) on outcomes is mostly unknown. This study estimated association NIDU with retention care, loss to follow up (LTFU), virologic failure (VF). Methods Individuals ≥18 years attending routine clinic visits completing Rapid Screening Tool (RST; evaluating ART adherence 7-day recall period) during 2012–13 were followed 2015 Caribbean, Central South...