Rosie Mngqibisa
A5091320018- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Reproductive Health and Contraception
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Lymphoma Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Cervical Cancer and HPV Research
- HIV, Drug Use, Sexual Risk
- Genital Health and Disease
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Respiratory viral infections research
- HIV/AIDS oral health manifestations
- Pharmaceutical studies and practices
- vaccines and immunoinformatics approaches
- Sex and Gender in Healthcare
- Herpesvirus Infections and Treatments
Wentworth Hospital
2021-2024
King Edward VIII Hospital
2022-2024
University of KwaZulu-Natal
2010-2024
AIDS Clinical Trials Group
2024
GlaxoSmithKline (India)
2024
Durban University of Technology
2014-2022
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens progress toward control the disease 2019 (Covid-19) pandemic. In a phase 1–2 trial involving healthy adults, NVX-CoV2373 nanoparticle vaccine had an acceptable safety profile and was associated with strong neutralizing-antibody antigen-specific polyfunctional CD4+ T-cell responses. Evaluation efficacy needed in setting ongoing SARS-CoV-2 transmission.
Peripartum administration of single-dose nevirapine reduces mother-to-child transmission human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus.In seven African countries, women infected with HIV-1 whose CD4+ T-cell counts were below 200 per cubic millimeter and who either had or not taken at least 6 months before enrollment randomly assigned to receive antiretroviral therapy tenofovir–emtricitabine plus tenofovir-emtricitabine lopinavir boosted by a low dose...
There is a paucity of data on COVID-19 vaccines in people living with HIV-1, who could be at increased risk severe illness and death from COVID-19. We evaluated the safety immunogenicity Matrix-M adjuvanted recombinant spike protein nanoparticle vaccine (NVX-CoV2373; Novavax) HIV-negative HIV-1.In this randomised, observer-blinded, multicentre, placebo-controlled phase 2A/B trial South Africa, participants aged 18-84 years, without underlying were enrolled 16 sites randomly assigned (1:1) to...
ABSTRACT Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens progress toward control the Covid-19 pandemic. Evaluation vaccine efficacy against SARS-CoV-2 is urgently needed to inform development and use. Methods In this phase 2a/b, multicenter, randomized, observer-blinded, placebo-controlled trial in South Africa, healthy human immunodeficiency virus (HIV)-negative adults (18 84 years) or medically stable people living with HIV (PLWH)...
Young children living with HIV have few treatment options. We aimed to assess the efficacy and safety of dolutegravir-based antiretroviral therapy (ART) in weighing between 3 kg less than 14 kg.ODYSSEY is an open-label, randomised, non-inferiority trial (10% margin) comparing ART standard care comprises two cohorts (children ≥14 <14 kg). Children starting first-line or second-line were enrolled seven centres South Africa, Uganda, Zimbabwe. Randomisation, which was computer generated by...
Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but factors for in these unclear. Methods: We used data from a multisite randomized trial comparing empiric vs. preventive tuberculosis adults initiating ART CD4+ T-cell counts less than 50 cells/μl to evaluate within 48 weeks initiation. Cox proportional hazards models were fit characteristics baseline and 4 including the week...
Guidelines for limited-stage human immunodeficiency virus-associated Kaposi sarcoma (AIDS/KS) recommend antiretroviral therapy (ART) as initial treatment. However, many such individuals show worsening KS and require additional chemotherapy. Methods to identify patients are lacking.
ObjectivesTo determine if double-dose levonorgestrel emergency contraception (EC) in combination with efavirenz or rifampicin, 2 drugs known to decrease exposure, resulted similar pharmacokinetics compared standard-dose EC without drug-drug interactions.Study DesignWe conducted a phase 2, open-label, multicenter, partially randomized, 4 parallel group trial pre-menopausal females ≥16 years old an indication for and not on hormonal contraception. Participants dolutegravir-based antiretroviral...
Abstract Background. Existing data on anthropomorphic changes in resource-limited settings primarily come from observational or cross-sectional studies. Data randomized clinical trials are needed to inform treatment decisions these areas of the world. Methods. The AIDS Clinical Trials Group Prospective Evaluation Antiretrovirals Resource-Limited Settings (PEARLS) study was a prospective, evaluation efficacy emtricitabine/tenofovir + efavirenz (FTC/TDF EFV) vs lamivudine/zidovudine (3TC/ZDV...
Tenofovir-lamivudine-dolutegravir (TLD) is the preferred first-line antiretroviral therapy (ART) regimen. An additional 50-mg dose of dolutegravir (TLD+50) required with rifampin-containing tuberculosis (TB) co-treatment. There are limited data on effectiveness TLD+50 in individuals TB/human immunodeficiency virus (HIV). We performed a prospective, observational cohort study at 12 sites Haiti, Kenya, Malawi, South Africa, Uganda, and Zimbabwe. Participants starting TLD TB treatment were...
Tuberculosis (TB) accounts for disproportionate morbidity and mortality among persons living with HIV (PLWH). Conventional methods of TB diagnosis, including smear microscopy Xpert MTB/RIF, have lower sensitivity in PLWH. Novel high-throughput approaches, such as miRNAomics metabolomics, may advance our ability to recognize subclinical difficult-to-diagnose TB, especially very advanced HIV. We conducted a case-control study leveraging REMEMBER, multi-country, open-label randomized controlled...
Serum albumin may be used to stratify human immunodeficiency virus (HIV)–infected persons with high CD4 count according their risk of serious non-AIDS endpoints. Cox proportional hazards models were analyze the events in Strategic Timing Antiretroviral Treatment (START) study (NCT00867048) serum as a fixed and time-updated predictor. Models exclusion during initial follow-up years built assess ability predict beyond shorter periods time. Secondarily, we considered hospitalizations AIDS...
Abstract Introduction ACTG A5288 was a strategy trial conducted in diverse populations from multiple continents of people living with HIV (PLWH) failing second‐line protease inhibitor (PI)‐based antiretroviral therapy (ART) 10 low‐ and middle‐income countries (LMICs). Participants resistant to lopinavir (LPV) and/or nucleotide reverse transcriptase inhibitors started on third‐line regimens that included raltegravir (RAL), darunavir/ritonavir (DRV/r) etravirine (ETR) according their...
Abstract Background Neurocognitive impairment remains a common complication of human immunodeficiency virus (HIV) despite effective antiretroviral therapy (ART). We previously reported improved neurocognitive functioning with ART initiation in 7 resource-limited countries for HIV+ participants from the AIDS Clinical Trials Group (ACTG) 5199 International Neurological Study (INS). Here, we apply normative data Normative (INNS) to INS provide unknown rates impairment. Methods The A5199...
Early progression of AIDS-associated Kaposi sarcoma (KS-PD) and immune reconstitution inflammatory syndrome (KS-IRIS) sometimes occur after the initiation antiretroviral therapy (ART).
Objective In AIDS Clinical Trials Group study A5375, a pharmacokinetic trial of levonorgestrel emergency contraception, double-dose (3 mg, versus standard dose 1.5 mg) offset the induction effects efavirenz or rifampin on plasma exposure over 8 h post-dose (AUC 0-8h ). We characterized pharmacogenetics these interactions. Methods Cisgender women receiving efavirenz- dolutegravir-based HIV therapy, isoniazid-rifampin for tuberculosis, were followed after single oral levonorgestrel. Linear...
Distal sensory peripheral neuropathy (DSPN) is a complication of human immunodeficiency virus (HIV). We estimate DSPN prevalence in 7 resource-limited settings (RLSs) for combination antiretroviral therapy (cART)-naive people living with HIV (PLWH) compared matched participants not and PLWH virally suppressed on 1 3 cART regimens.
To characterize diet quality across a global cohort of people with HIV (PWH).
Background: Convenient dosing, potency, and low toxicity support use of tenofovir disoproxil fumarate (TDF) as preferred nucleotide reverse transcriptase inhibitor (NRTI) for HIV-1 treatment. However, renal metabolic safety TDF compared to other NRTIs has not been well described in resource-limited settings. Methods: This was a secondary analysis examining the occurrence abnormalities (RAs) serious non-AIDS-defining events (SNADEs) through study follow-up between participants randomized...