A5021397433- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Sex and Gender in Healthcare
- HIV/AIDS drug development and treatment
- Diversity and Career in Medicine
- Ethics in Clinical Research
- Adolescent Sexual and Reproductive Health
- Reproductive Health and Contraception
- Gender Roles and Identity Studies
- HIV, Drug Use, Sexual Risk
- Pregnancy and Medication Impact
- Obesity and Health Practices
- Pharmacological Effects and Toxicity Studies
- COVID-19 Impact on Reproduction
- Poverty, Education, and Child Welfare
- HIV-related health complications and treatments
- Intimate Partner and Family Violence
- Global Cancer Incidence and Screening
- Mentoring and Academic Development
- Chronic Disease Management Strategies
- Healthcare Systems and Challenges
- HIV/AIDS Impact and Responses
- Sex work and related issues
- Pregnancy and preeclampsia studies
- LGBTQ Health, Identity, and Policy
Office of the Director
2021-2024
National Institutes of Health
2021-2024
AIDS Clinical Trials Group
2016-2024
American Medical Association
2023
New York University
2023
University of Baltimore
2021
University of Maryland, Baltimore County
2019-2020
Treatment Action Group
2019-2020
Johns Hopkins University
2019
Development of human immunodeficiency virus (HIV) remission strategies requires precise information on time to HIV rebound after treatment interruption, but there is uncertainty regarding whether modern antiretroviral therapy (ART) regimens and timing ART initiation may affect this outcome.AIDS Clinical Trials Group (ACTG) A5345 enrolled individuals who initiated during chronic or early infection suppressive for ≥2 years. Participants underwent carefully monitored interruption. was restarted...
Abstract Gender is a social and structural variable that encompasses multiple domains, each of which influences health: gender identity expression, roles norms, gendered power relations, equality equity. As such, has far-reaching impacts on health. Additional research needed to continue delineating untangling the effects from sex other biological variables. The National Institutes Health (NIH) vision for women’s health world in influence and/or are integrated into enterprise. However, much...
BACKGROUND. Identifying factors that predict the timing of HIV rebound after treatment interruption will be crucial for designing and evaluating interventions remission.
Historically, the physician professional identity and organizational structure of Western medicine have been defined by masculine norms such as authority assertiveness. The past five decades seen a rapid shift in demographics attendees medical schools, with equal numbers women men matriculants for nearly twenty years. Gender social, cultural, structural variable continues to influence workforce. entry into medicine, has had far reaching effects on expectations patients, interactions...
Despite progress toward equity within our broad social context, the domains of gender as a social, cultural, and structural variable continue to exert influence on delivery oncology care. Although there have been vast advances in understanding biological underpinnings cancer significant improvements clinical care, disparities care for all women—including cisgender, transgender, diverse women—persist. Similarly, despite inclusion physician workforce, women minorities, particularly those with...
There are two concurrent and novel major research pathways toward strategies for HIV control: (1) long-acting antiretroviral therapy (ART) formulations (2) aimed at conferring sustained ART-free remission, considered a step an cure. The importance of perspectives from people living with on the development new modalities is high, but data lacking. We administered online survey in which respondents selected their likelihood participation or nonparticipation cure/remission based potential risks...
Women remain underrepresented in HIV research. The AIDS Clinical Trials Group (ACTG) 5366 study was the first cure-related trial conducted exclusively women. Our multidisciplinary team integrated participant-centered reports into ACTG protocol to elicit their perspectives. We nested mixed-methods surveys at enrollment and final visits assess participants' perceptions experiences. Of 31 participants enrolled 5366, 29 agreed complete entry questionnaire 27 completed exit survey. majority of...
ObjectivesTo determine if double-dose levonorgestrel emergency contraception (EC) in combination with efavirenz or rifampicin, 2 drugs known to decrease exposure, resulted similar pharmacokinetics compared standard-dose EC without drug-drug interactions.Study DesignWe conducted a phase 2, open-label, multicenter, partially randomized, 4 parallel group trial pre-menopausal females ≥16 years old an indication for and not on hormonal contraception. Participants dolutegravir-based antiretroviral...
In 2018, we surveyed investigators conducting HIV cure-related clinical research, drawing on information from the online listing established by Treatment Action Group (TAG). The purpose of survey was to facilitate a landscape analysis field. 2019, fielded second in order provide updated and assess any shifts landscape.Trials observational studies listed as August 16, 2019 formed sample set. Survey questions addressed funding, trial development, recruitment, enrollment, participant...
Cisgender women represent over half of people living with HIV globally. However, current research efforts toward a cure for focus predominantly on cisgender men. The under-representation in clinical studies is particularly problematic given data suggesting that sex-dependent phenotypes limit scientific discovery.
The AIDS Clinical Trials Group A5345 study (NCT03001128) included an intensively monitored antiretroviral pause (IMAP), during which participants living with HIV temporarily stopped treatment (ART) in effort to identify biomarkers that could predict rebound. We evaluated the potential impact of IMAP on United States by questioning them immediately after and at end study. administered longitudinal sociobehavioral questionnaires following when they resumed ART summarized descriptive data from...
Objective In AIDS Clinical Trials Group study A5375, a pharmacokinetic trial of levonorgestrel emergency contraception, double-dose (3 mg, versus standard dose 1.5 mg) offset the induction effects efavirenz or rifampin on plasma exposure over 8 h post-dose (AUC 0-8h ). We characterized pharmacogenetics these interactions. Methods Cisgender women receiving efavirenz- dolutegravir-based HIV therapy, isoniazid-rifampin for tuberculosis, were followed after single oral levonorgestrel. Linear...
The AIDS Clinical Trials Group (ACTG) A5345 study included an intensively monitored antiretroviral pause (IMAP), during which a cohort of participants temporarily stopped treatment chronic HIV infection. We surveyed participant perceptions and understanding using cross-sectional sociobehavioral questionnaire. Participants completed the baseline questionnaire either before or after initiating study's IMAP. Questionnaire responses were linked to existing demographic data. Quantitative analyzed...
Abstract Sex and gender influence every aspect of human health; thus, sex- gender-related topics should be incorporated in all aspects health education curricula. (SGHE) is the rigorous, intersectional, data-driven integration sex into elements education. A multisectoral group thought leaders has collaborated to advance SGHE since 2012. This cross-sector collaboration been successful on several fronts, primarily developing robust interprofessional programs, hosting a series international...
Women are underrepresented in human immunodeficiency virus (HIV) research the United States. To determine if women screening for HIV clinical trials enrolled at lower rates than men, we performed a retrospective, cross-trial analysis.We conducted an analysis of and enrollment during 2003-2013 to 31 99 AIDS Clinical Trials Group network sites Random-effects meta regression estimated whether sex differences not enrolling ("screen out") varied by various individual, trial, or site...
Objectives: To assist with planning a congressionally requested conference on women's health research, the National Institutes of Health (NIH) Office Research Women's (ORWH) invited comments to characterize public concerns related any or all specified issues: maternal morbidity and mortality (MMM); stagnant rates cervical cancer survival; growing incidence chronic debilitating conditions in women (CDCW). This analysis summarizes priorities research. Materials Methods: All received response...