A5077212574- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Ethics in Clinical Research
- Palliative Care and End-of-Life Issues
- Grief, Bereavement, and Mental Health
- HIV, Drug Use, Sexual Risk
- Biomedical Ethics and Regulation
- HIV/AIDS drug development and treatment
- Patient Dignity and Privacy
- CRISPR and Genetic Engineering
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Virus-based gene therapy research
- Surgical Simulation and Training
- Elbow and Forearm Trauma Treatment
- Hormonal and reproductive studies
- Dupuytren's Contracture and Treatments
- Hepatitis C virus research
- Reproductive Health and Technologies
- Muscle and Compartmental Disorders
- Anatomy and Medical Technology
- Bone Tumor Diagnosis and Treatments
- Autism Spectrum Disorder Research
- Systemic Lupus Erythematosus Research
University of California, San Diego
2023-2025
Kansas City University
2024-2025
University of California System
2023
University of North Carolina at Chapel Hill
2018-2022
Current trials toward an HIV cure involve combination strategies aimed at achieving durable antiretroviral treatment (ART)-free viral control or elimination, many relying on analytical interruptions (ATIs) to evaluate efficacy. Given the physical, psychosocial, and interpersonal risks associated with ATIs, it is critical monitor participants' experiences so that support can be provided when needed. While qualitative approaches have been used in similar settings, we designed implemented a...
Osteoarthritis (OA) of the first carpometacarpal (CMC) joint, or basilar thumb arthritis, is most common symptomatic hand leading to significant healthcare costs. This study analyzed trends in managing arthritis and determined approaches linked favorable outcomes guide future treatments. retrospective cohort queried TriNetX United States Collaborative Network from 2013 2023. Patients with primary OA CMC joint were identified using International Classification Diseases-10 codes, surgical...
There are two concurrent and novel major research pathways toward strategies for HIV control: (1) long-acting antiretroviral therapy (ART) formulations (2) aimed at conferring sustained ART-free remission, considered a step an cure. The importance of perspectives from people living with on the development new modalities is high, but data lacking. We administered online survey in which respondents selected their likelihood participation or nonparticipation cure/remission based potential risks...
Multiple strategies to cure HIV infection are under investigation, including cell and gene therapy (C>) approaches. Research, ultimately treatment, with these novel will require patients' willingness participate. To elicit the perspectives of people living specific approaches, we conducted 4 focus group discussions a diverse 19 English-speaking men women in care at large academic clinic northwestern United States. Thematic analysis indicated participants expressed initial fear about C>...
The question of what motivates people to participate in research is particularly salient the HIV field. While participation was driven by survival 1980's and early 1990's, access novel therapies became primary motivator with advent combination antiretroviral therapy (cART) late 1990s. In cure-related context, concept altruism has remained insufficiently studied.
The U.S. National Institute of Allergies and Infectious Diseases (NIAID) the Mental Health (NIMH) have a new research priority: inclusion terminally ill persons living with HIV (PLWHIV) in cure-related research. For example, Last Gift is clinical study at University California San Diego (UCSD) for PLWHIV who terminal illness, prognosis less than 6 months. As end-of-life (EOL) cure relatively new, scientific community has timely opportunity to examine related ethical challenges. Following an...
End-of-life (EOL) HIV cure-related research provides a novel approach to studying reservoirs. The Last Gift is rapid autopsy study at the University of California San Diego that enrolls terminally ill people living with (PLWHIV) desire contribute research. We conducted in-depth baseline and follow-up interviews participants. analyzed interview data applying conventional content analysis. Since summer 2017, 13 participants have been enrolled (
Background: HIV cure-directed clinical trials using analytical treatment interruptions (ATIs) require participants to adhere frequent monitoring visits for viral load tests. Novel strategies are needed decrease participant burden during ATIs.Objective: To examine acceptability of a novel home-based blood collection device testing in the context two ongoing ATI Philadelphia, PA, United States.Methods: From January 2021 February 2022, completed three in-depth interviews via teleconference...
A growing number of people living with HIV/AIDS are participating in HIV cure-related research at the end life (EOL). Due to novelty EOL research, there is a need understand how their next-of-kin (NOK) perceive such research. We conducted in-depth interviews NOK Last Gift study participants University California, San Diego. The occurs context and involves full body donation. completed two interviews: (1) shortly after participants' enrollment (2) following death. applied thematic analysis...
For over a decade, the binary concepts of 'sterilizing' versus 'functional' cure have provided an organizing framework for field HIV cure-related research. In this article, we examine how expression 'functional cure' is employed within field, published literature, and community understanding our synthesis different meanings attributed to contemporary biomedical discourse, argue that employing terminology poses series problems. The itself contradictory inconsistently used across wide array...
Advancements in long-acting (LA) HIV treatment and cure research with analytical interruptions (ATIs) have generated important scientific implementation questions. There is an urgent need to examine challenges navigating the evolving landscape. From August October 2022, we conducted 26 semistructured interviews biomedical researchers community members representing a predominantly woman demographic explore complexity of rapidly therapeutic We purposively sampled individuals recruited from...
As end-of-life (EOL) HIV cure-related research expands, understanding perspectives of participants’ next-of-kin (NOK) is critical to maintaining ethical study conduct. We conducted two small focus groups and one-on-one interviews using group guides with the NOK Last Gift participants at University California, San Diego (UCSD). Participating included six individuals ( n = 5 male 1 female), including a grandmother, grandfather, partner, spouse, close friends. Researchers double-coded...
Background: Research on stakeholder perspectives of HIV cure research has involved people with (PWH), who generally cite the importance clinician advice in making decisions about trial participation. However, there been little exploration non-researcher community perspectives, which are clearly critical to success cure-related research.Objective: We aimed learn how clinicians perceive and identify factors that would lead them support or discourage participation by their patients.Methods:...
Abstract Background One of the next frontiers in HIV research is focused on finding a cure. A new priority includes people with (PWH) non-AIDS terminal illnesses who are willing to donate their bodies at end-of-life (EOL) advance search towards an We endeavored understand perceptions this and identify ethical practical considerations relevant implementing it. Methods conducted 20 in-depth interviews 3 virtual focus groups among four types key stakeholders United States (PWH, biomedical cure...
Background A unique window of opportunity currently exists to generate ethical and practical considerations presented by interventional HIV cure-related research at the end-of-life (EOL). Because participants would enroll in these studies for almost completely altruistic reasons, they are owed highest standards, safeguards, protections. This qualitative empirical ethics study sought identify EOL. Methods findings We conducted 20 in-depth interviews three virtual focus groups (N = 36) with...
The Last Gift is an observational HIV cure-related research study conducted with people at the end of life (EOL) University California San Diego. Participants agree to voluntarily donate blood and other biospecimens while living their bodies for a rapid autopsy postmortem better understand reservoir dynamics throughout entire body. was initiated in 2017. Since then, 30 volunteers were enrolled who are either (1) terminally ill concomitant condition have prognosis 6 months or less (2)...
Introduction Little is known about the effects of HIV reservoir research at end life on staff members involved. Staff members’ perceptions and experiences were assessed related to their involvement in Last Gift, a rapid autopsy study University California San Diego enrolling people living with who are terminally ill have desire contribute cure-related research. Methods Two focus group discussions consisting clinical ( n = 7) 8) conducted understand perspectives impact Gift had them. The...
Abstract Background HIV cure research involving cell and gene therapy has intensified in recent years. There is a growing need to identify ethical standards safeguards ensure (CGT) remains valued acceptable as many stakeholders possible it advances on global scale. Methods To elicit preliminary practical considerations guide CGT research, we implemented qualitative, in-depth interview study with three key stakeholder groups the United States: (1) biomedical researchers, (2) bioethicists, (3)...
A man in his 30s came to our clinic with a year-long history of progressive pain and swelling knee. Diagnostic imaging revealed displaced patellar fracture an osteolytic, septated lesion thinned expanded cortex both fragments. core needle biopsy confirmed the diagnosis giant cell tumour. Treatment involved wide excision tumour use polypropylene mesh peroneal longus tendon autograft reconstruct extensor mechanism knee joint. One year postoperatively, patient experienced no pain, demonstrated...
Introduction Recently within surgical education, the development of extended reality (XR) devices has become a topic interest to improve trainees’ technique outside operating room. There is growing body literature which supports use XR, and it important understand perceptions orthopedic surgery trainees on XR as an adjunct during training. Purpose Understand adjunctive training tool. Methods An internally validated 18-question survey was sent all US residency program coordinators with intent...