A5035607585- CAR-T cell therapy research
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Biomedical Ethics and Regulation
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Biomedical and Engineering Education
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Nanowire Synthesis and Applications
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Advancements in Semiconductor Devices and Circuit Design
- Prenatal Screening and Diagnostics
Capital Caring
2022-2024
University of Houston
2012-2023
The University of Texas at Austin
2023
Lentigen Technology (United States)
2019-2022
Trispecific duoCAR-T cells with optimized costimulatory domains effectively kill tumor in antigen-heterogeneous and antigen-replete models.
Multispecific duoCAR-T cells potently suppress HIV infection in a humanized mouse model.
HIV-specific chimeric antigen receptor–T cell (CAR T cell) therapies are candidates to functionally cure HIV infection in people with (PWH) by eliminating reactivated HIV-infected cells derived from latently infected within the reservoir. Paramount translating such therapeutic successfully into clinic will require anti-HIV CAR localize lymphoid tissues body and eliminate as CD4+ monocytes/macrophages. Here we show that i.v. injected duoCAR cells, generated using a clinical-grade lentiviral...
Recent work has shown that the combinatorial use of multiple TALE activators can selectively activate certain cellular genes in inaccessible chromatin regions. In this study, we aimed to interrogate activation potential TALEs upon transcriptionally silenced immune context non-immune cells. We designed a unique strategy, which single fused TATA-box binding protein (TBP-TALE) is coupled with VP64-TALE activators. found our strategy significantly more potent than alone activating expression...
Abstract Background HIV cure research involving cell and gene therapy has intensified in recent years. There is a growing need to identify ethical standards safeguards ensure (CGT) remains valued acceptable as many stakeholders possible it advances on global scale. Methods To elicit preliminary practical considerations guide CGT research, we implemented qualitative, in-depth interview study with three key stakeholder groups the United States: (1) biomedical researchers, (2) bioethicists, (3)...
Background While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility these circulating prenatal diagnosis, early cancer detection, diagnosis infectious diseases. However, DNA blood is usually present at very low concentrations (ng/ml), form relatively small fragments (<1,000 bp), making its isolation challenging. Methods Here we...