A5087351037- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Air Quality and Health Impacts
- Animal Ecology and Behavior Studies
- Gut microbiota and health
- MicroRNA in disease regulation
- Multiple and Secondary Primary Cancers
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- T-cell and Retrovirus Studies
- Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Inflammatory Biomarkers in Disease Prognosis
- Reproductive System and Pregnancy
- Per- and polyfluoroalkyl substances research
University of California, Los Angeles
2015-2025
Black AIDS Institute
2014-2025
UCLA Health
2025
University of California, San Francisco
2024
Icahn School of Medicine at Mount Sinai
2024
City of Hope
2024
UCLA Jonsson Comprehensive Cancer Center
2015-2021
University of California, Santa Cruz
2018
Duke University
2018
University of California, Davis
2018
Understanding how human activities influence immune response to environmental stressors can support biodiversity conservation across increasingly urbanizing landscapes. We studied a bobcat ( Lynx rufus ) population in urban southern California that experienced rapid decline from 2002–2005 due notoedric mange. Because anticoagulant rodenticide (AR) exposure was an underlying complication mange deaths, we aimed understand sublethal contributions of urbanization and ARs on 65 biochemical...
BACKGROUND. Inflammation is implicated in many aging-related disorders. In animal models, menopause leads to increased gut permeability and inflammation. Our primary objective was determine if increases during the transition (MT) women. exploratory objectives were examine whether greater associated with more inflammation lower bone mineral density (BMD).
ABSTRACT Problem Regulatory B‐cells (Bregs, CD19 + CD24 hi CD38 ) are a specialized B‐cell subset that suppresses immune responses and potentially contribute to the maintenance of an immune‐privileged environment for fetal development during pregnancy. However, little is known about surrounding immunological Bregs in gestational physiology. The relationship regulatory T‐cells (Tregs, CD4 CD25 CD127 lo FoxP3 coordinating immunoregulation pregnancy unknown. We aimed determine whether...
Introduction: Ambient air pollution (particulate matter (PM) 2.5, defined as particles < 2.5 microns in diameter) has long been linked to increased stroke risk. However, few studies have described the specific sources or estimated effects of PM2.5 constituents responsible for and subtype Hypothesis: We hypothesize that chronic long-term exposure a major source pollution, transportation its related constituents, will be associated with elevated Methods: In prospective cohort study 133,477...
Introduction: Ambient air pollution is linked to increased stroke risk, but it unclear if associations apply long-term exposures, equally different subtypes (ischemic versus hemorrhagic) and differ by pollutants. Of particular interest exposure ultrafine particles (PM0.1) for which there sparse literature on its association with stroke. Hypothesis: Long-term exposures particulate matter (PM0 2.5, PM10, PM0.1), ozone (O 3 ), nitrogen dioxide (NO 2 ) are associated risk. Methods: In a...
Objective To evaluate the associations between brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs), exposure and circulating immune markers in a subset of women from California Teachers Study cohort. Methods In this cross-sectional study, serum 813 female participants collected 2013–2016 were evaluated for 11 BFR congeners 16 markers. Three [BDE153 [2,2′,4,4′,5,5′-Hexabromodiphenyl ether], BDE47 [2,2′,4,4′-Tetrabromodiphenyl PBB153...
Background: Chronic immune activation is a harbinger of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL), yet the underlying basis unclear. Microbial translocation, passage microbial components from gastrointestinal tract into systemic circulation, source in HIV infection and may be an important contributor to chronic B-cell subsequent AIDS-NHL development. Method: We measured biomarkers translocation including bacterial receptors/antibodies, intestinal barrier proteins, macrophage...
Gut microbial dysbiosis contributes to colorectal cancer (CRC) pathogenesis, possibly mediated in part by increased intestinal permeability endotoxin lipopolysaccharide (LPS), translocation, and subsequent endotoxemia inflammation. However, epidemiologic evidence linking circulating markers of translocation with CRC risk is limited.We conducted a prospective, nested case-control study 261 incident cases controls (matched on age time blood draw) among 18,159 men pre-diagnostic specimens the...
Non-Hodgkin's B cell lymphoma (NHL) is a common cancer in HIV infection. Many NHL are thought to result from errors class switch recombination and/or somatic hypermutation, processes that occur germinal center cells, and require the activity of activation induced cytidine deaminase (AID). Since infection, expression AID could contribute development NHL, we hypothesized would be elevated those who went on develop AIDS-associated (AIDS-NHL). mRNA levels were measured by TaqMan RT-PCR...
Most AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) arises from errors in immunoglobulin heavy-chain gene (IgH) class switch recombination (CSR) or somatic hypermutation (SHM), events that occur germinal center (GC) B cells and require the activity of activation induced cytidine deaminase (AID). Several oncogenic viruses (EBV, HCV, HPV) can induce AID (AID) expression, elevated expression is seen circulating lymphocytes prior to AIDS-NHL diagnosis. Here, we report HIV produced peripheral...
Type I interferons have been typically studied for their effects in the context of bacterial or viral infections. However this report, we provide evidence that Interferon-alpha (IFN-α) expressing cells are present thymus absence infection. We show pDC express highest level IFN-α and MxA, which is exclusively expressed after engagement type IFN receptor by IFN-α/β, normal fetal post-natal thymus, but not periphery. The MxA mature thymocytes located medulla at cortico-medullary junction....
Guidelines for limited-stage human immunodeficiency virus-associated Kaposi sarcoma (AIDS/KS) recommend antiretroviral therapy (ART) as initial treatment. However, many such individuals show worsening KS and require additional chemotherapy. Methods to identify patients are lacking.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that have been linked to a number of health outcomes, including those related immune dysfunction. However, there limited numbers epidemiological-based studies directly examine the association between PFAS exposure responses.
CD30, first described as the Ki antigen on malignant B cells in Hodgkin’s lymphoma, is also expressed normal activated and T cells. It can be cleaved from cell surface detected serum soluble CD30 (sCD30), where it an indicator of levels immune activation. In a cross-sectional study utilizing archived sera at time point close to but preceding diagnosis acquired immunodeficiency syndrome (AIDS)-associated non-Hodgkin’s AIDS lymphoma subjects (n = 49) showed elevated mean sCD30 compared...
Abstract The risk for non-Hodgkin lymphoma (NHL) is markedly increased in persons living with human immunodeficiency virus (HIV) infection, and remains elevated those on anti-retroviral therapy (cART). Both the loss of immunoregulation Epstein-Barr (EBV) infected cells, as well chronic B-cell activation, are believed to contribute genesis AIDS-related NHL (AIDS-NHL). However, mechanisms that lead AIDS-NHL have not been completely defined. A subset B cells characterized by secretion IL10,...
Abstract BACKGROUND Homocysteine is a nonessential aminoacid whose increase related to the appearance of neural tube defects in humans. In chick embryos, high levels homocysteine produce and alteration crest cell migration. METHODS our study, 8 μl L ‐homocysteine thiolactone (20 μmol) was added embryos Stages 3–8/10 (Hamburger Hamilton, 1951 ), (12–38 hr incubation). Three days later, 50 externally normal or carrying isolated spinal defects, were sectioned stained by hematoxilin‐eosin...
Abstract Background The formation of the neural tube (neurulation) involves two mechanisms: primary and secondary neurulation. In chicks, there is also an overlap zone, where both mechanisms work together. Homocysteine (Hcy) may have important teratogenic role in defects (NTD) when folic acid levels are considered normal. Recently, Hcy capability to generate NTD modify crest cell migration has been demonstrated chick embryos. This study was aimed evaluate effects on neurulation development...
The aims of this study were to determine whether pretreatment plasma levels cytokines and immune activation-associated molecules changed following treatment for AIDS-NHL with rituximab plus infusional EPOCH, these associated response and/or survival.We quantified B-cell (sCD27, sCD30, sCD23) (IL6, IL10, CXCL13) before after the initiation in persons (n = 69) AIDS Malignancies Consortium (AMC) 034 study, which evaluated EPOCH chemotherapy rituximab.Treatment resulted decreased some (CXCL13,...
Infection by Kaposi sarcoma-associated herpesvirus (KSHV) can cause severe consequences, such as cancers and lymphoproliferative diseases. Whole inactivated viruses (WIV) with chemically destroyed genetic materials have been used antigens in several licensed vaccines. During KSHV productive replication, virus-like vesicles (VLVs) that lack capsids viral genomes are generated along virions. Here, we investigated the immunogenicity of VLVs produced from a mutant was defective capsid formation...
In contrast to peripheral plasmacytoid DCs (pDCs), thymic pDCs constitutively express low levels of IFN-α. This leads induction interferon secondary genes (ISGs) in medullary thymocytes, raising the question whether IFN-α may play a role T-cell development. When characterizing further differences between and pDCs, we found that have phenotype consistent with an "activated signature" including expression TNF-α bone marrow stromal cell antigen 2 (BST2), but no ILT7. Given BST2 is induced by...
Abstract Emerging evidence shows that tumor cells secrete extracellular vesicles (EVs) carry bioactive cell surface markers, such as programmed death-ligand 1 (PD-L1), which can modulate immune responses and inhibit anti-tumor responses, potentially playing a role in lymphomagenesis promoting the growth of these cancers. In this study, we investigated EVs expressing molecules associated with B activation regulation. We measured levels derived from plasma 57 subjects AIDS-related non-Hodgkin...