A5029562926- Viral-associated cancers and disorders
- HIV/AIDS Research and Interventions
- Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- Cervical Cancer and HPV Research
- HIV Research and Treatment
- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- Colorectal Cancer Screening and Detection
- Polyomavirus and related diseases
- HIV/AIDS drug development and treatment
- Chronic Lymphocytic Leukemia Research
- Innovations in Medical Education
- Histiocytic Disorders and Treatments
- Advances in Oncology and Radiotherapy
- Global Health Workforce Issues
- Global Health and Surgery
- HIV/AIDS Impact and Responses
- CNS Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Economic and Financial Impacts of Cancer
- Esophageal Cancer Research and Treatment
- Pharmaceutical Economics and Policy
University of Zimbabwe
2014-2025
National Blood Service Zimbabwe
2003-2023
University of Colorado Anschutz Medical Campus
2023
London School of Hygiene & Tropical Medicine
2023
Sapienza University of Rome
2023
Chinhoyi University of Technology
2022
Parirenyatwa Hospital
2013-2021
National Cancer Registration Service
2020
Cancer Association of South Africa
2018
Joint Clinical Research Centre
2013
Breast cancer is the leading diagnosis and second most common cause of deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from none on differences by stage at diagnosis. Here, we estimate breast within SSA area, country-level human development index (HDI). We obtained a random sample 2,588 incident cases, diagnosed 2008-2015 14 population-based registries 12 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mali, Mauritius, Mozambique, Namibia, Seychelles,...
Cervical cancer is the second most common and leading cause of death in women sub-Saharan Africa (SSA).
BackgroundWHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed examine whether is non-inferior darunavir, the best-in-class protease inhibitor drug, and maintaining in therapy zidovudine.MethodsIn this prospective, multicentre, open-label, factorial, randomised, non-inferiority trial (NADIA), participants confirmed treatment failure (HIV-1 RNA ≥1000...
Incidence rates of different cancers have been calculated for the black population Harare, Zimbabwe a 20‐year period (1991–2010) coinciding with continuing social and lifestyle changes, peak, subsequent wane, HIV‐AIDS epidemic. The overall risk cancer increased during in both sexes, cervix prostate showing particularly dramatic increases (3.3% 6.4% annually, respectively). By 2004, had become most common men. incidence esophagus, formerly men, has remained relatively constant, whereas breast...
Abstract Cervical cancer is the leading cause of death in African women. We sought to estimate population‐based survival and evaluate excess hazards for mortality women with cervical cancer, examining effects country‐level Human Development Index (HDI), age stage at diagnosis. selected a random sample 2760 incident cases, diagnosed 2005 2015 from 13 registries 11 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Uganda Zimbabwe)...
Objective To determine the relationship between human herpesvirus 8 (HHV-8 or Kaposi's sarcoma-associated herpesvirus) peripheral blood virus load and sarcoma (KS) clinical stage. Design Blinded, cross-sectional analysis of HHV-8 DNA levels in persons with AIDS-related KS Harare, Zimbabwe. Methods Subjects were stratified by The amount plasma mononuclear cells (PBMC) was determined quantitative real-time PCR amplification open reading frame 26. Results Thirty-one HIV-1/HHV-8-coinfected...
Due to the scale up of antiretroviral therapy, increasing numbers HIV-infected children are living into adolescence. As these grow and surpass immediate threat death, issue informing them their HIV status arises. This study aimed understand how perinatally-infected adolescents learn about HIV-status as well examine preferences for disclosure process.In-depth interviews were conducted with 31 (14 male, 17 female) aged 16-20 at an clinic in Harare, Zimbabwe, focused on adolescents' experiences...
The widespread availability of antiretroviral therapy (ART) has dramatically reduced mortality and improved life expectancy for people living with HIV (PLWH). However, even HIV-1 suppression, chronic immune activation elevated inflammation persist have been linked to a pro-inflammatory gut microbiome composition compromised intestinal barrier integrity. PLWH in urban versus rural areas sub-Saharan Africa experience differences environmental factors that may impact the system, response ART,...
In this randomized controlled study, individuals taking dolutegravir+darunavir/ritonavir had greater increases in systolic and diastolic blood pressure than those 2 nucleoside reverse-transcriptase inhibitors+darunavir/ritonavir at week-48. The difference remained significant after controlling for confounding factors, including weight gain.
Background: Zimbabwe is severely affected by the AIDS epidemic, and many cancers in African populations are related to infectious agents. Objective: To study current pattern, short-term changes incidence, of agents (and especially HIV), with respect evolving epidemic AIDS. Methods: Analysis data on population Harare, Zimbabwe, from Cancer Registry, for period 1990-1995. Comparison prevalence HIV seropositivity, notifications Results: Comparing results 1993-1995 those 1990-1992 shows a...
Abstract Individuals with AIDS and Kaposi sarcoma (AIDS‐KS) pulmonary involvement have high‐risk of poor outcomes but diagnosis KS in low‐resource settings is difficult. We aimed to discover plasma proteins that distinguish individuals from those without involvement. SomaScan proteomics screen measured 7288 22 cases 17 controls selected 181 participants HIV‐1 cutaneous who underwent bronchoscopy. Cases had the lower respiratory tract by Controls no lesions detected Results were confirmed...
The usefulness of plasma human herpesvirus 8 (HHV-8) DNA as a marker response to treatment for acquired immunodeficiency syndrome-associated Kaposi sarcoma (AIDS-KS) in an African setting is unknown.We conducted prospective pilot study at the Parirenyatwa Hospital Sarcoma Clinic (Harare, Zimbabwe) investigate hypothesis that clinical AIDS-KS associated with suppression HHV-8 DNA. Antiretroviral therapy (ART) was provided coformulation abacavir, lamivudine, and zidovudine. Clinical defined...
Cancers occurring in children Africa are often underdiagnosed, or at best diagnosed late. As a result, survival is poor, even for cancers considered 'curable'. With limited population-level data, understanding the actual burden and from childhood difficult. In this study, we aimed providing estimates most common types of affecting aged 0-14 years, three population-based Eastern African registries; Harare, Zimbabwe (Kaposi sarcoma, Wilms tumour (WT), non-Hodgkin lymphoma (NHL),...
Abstract This paper provides the first comprehensive population based cancer survival estimates from African continent. Five‐year absolute and relative are presented for black white Zimbabwean patients diagnosed with in Harare, Zimbabwe between years 1993 1997. The of among lowest ever reported registries. For most sites, have much higher than Zimbabweans, except lung colorectal cancer, which similarly poor. Race specific comparisons to United States show that lower American gap is broader...
Mild-to-moderate AIDS-associated Kaposi sarcoma (KS) often responds to antiretroviral therapy (ART) alone; the role of chemotherapy is unclear. We assessed impact immediate vs as-needed oral etoposide (ET) among human immunodeficiency virus (HIV)-infected individuals with mild-to-moderate KS initiating ART.Chemotherapy-naive, HIV type 1-infected adults ART in Africa and South America were randomized (tenofovir/emtricitabine/efavirenz) alone (chemotherapy "as-needed" arm) plus up 8 cycles ET...
Kaposi's sarcoma is currently the most common tumor in Zimbabwe. The purpose of our study to compare effectiveness supportive care vs. 3 intervention approaches, namely oral Etoposide, a 3-drug combination, and radiotherapy using quality life (QOL) as primary measure success. In addition, was determine whether disease-specific module has greater sensitivity group differences than generic QOL questionnaire pragmatic approach treating epidemic (EKS) Histologically confirmed HIV-positive...
Kaposi's sarcoma—associated herpesvirus (KSHV) in oral and genital secretions of women may be involved horizontal vertical transmission endemic regions. Nested polymerase chain reaction assays were used to detect KSHV DNA sequences one-third oral, vaginal, cervical specimens 42% peripheral blood mononuclear cell (PBMC) collected from 41 infected with human immunodeficiency virus type 1 who had sarcoma (KS). was not detected 100 without KS, 9 whom seropositive for KSHV. A positive association...