A5101752989- HIV/AIDS Research and Interventions
- Pharmacogenetics and Drug Metabolism
- Hemoglobinopathies and Related Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Prenatal Screening and Diagnostics
- HIV/AIDS drug development and treatment
- Epigenetics and DNA Methylation
- PARP inhibition in cancer therapy
- Viral-associated cancers and disorders
- Medication Adherence and Compliance
- Erythrocyte Function and Pathophysiology
- Estrogen and related hormone effects
- Wikis in Education and Collaboration
- Animal testing and alternatives
- Inflammatory mediators and NSAID effects
- Genomic variations and chromosomal abnormalities
- Cytomegalovirus and herpesvirus research
- Forensic and Genetic Research
- BRCA gene mutations in cancer
- Single-cell and spatial transcriptomics
- Chemotherapy-induced cardiotoxicity and mitigation
- Open Education and E-Learning
- Chronic Lymphocytic Leukemia Research
African Institute of Biomedical Science and Technology
2020-2025
University of the Witwatersrand
2020-2025
Abstract We analyzed parentage data collected over a ten-year period in Zimbabwean DNA testing laboratory. Parentage case types, prevalence, exclusion data, mutations rates and observed genotyping irregularities were analyzed. report analysis results from 1303 cases. extraction STR typing was conducted using standard commercial kits. Paternity the most requested test (87.37%) followed by indirect biological kinship tests (7.01%). Duo paternity (motherless) common for both regular court 367...
Fluoropyrimidines are commonly used in the treatment of colorectal cancer. They are, however, associated with adverse events (AEs), which gastrointestinal, myelosuppression and palmar-plantar erythrodysesthesia most common. Clinical guidelines for fluoropyrimidine dosing based on dihydropyrimidine dehydrogenase (DPYD) genetic polymorphism have been shown to reduce these AEs patients European ancestry. This study aimed evaluate, first time, clinical applicability a cohort cancer standard care...
Chloroquine/hydroxychloroquine have been proposed as potential treatments for COVID-19. These drugs warning labels use in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Analysis of whole genome sequence data 458 from sub-Saharan Africa showed significant G6PD variation across the continent. We identified nine variants, which four are potentially deleterious to function, and one (rs1050828) that is known cause supplemented rs1050828 variant genotype array over 11,000...
Abstract Tamoxifen is the most used hormonal therapy for oestrogen receptor‐positive breast cancer. CYP2D6 main enzyme in metabolic pathway of tamoxifen to endoxifen. Variations endoxifen plasma concentrations are associated with polymorphisms. This study aimed determine association between polymorphisms and a cohort Zimbabwean cancer patients ( n = 40). TaqMan genotyping copy number assays were done genotypes. metabolites quantitated using LC‐MS/MS. The population had high frequencies...
The Mu ( �) and Theta Θ) classes of glutathione transferase gene, GSTM1 GSTT1 are polymorphic in humans. enzyme deficiencies have been suggested to predispose people lung, bladder colorectal cancer. This study was carried out investigate the distribution Glutathione transferases (GSTs) genotype frequency three major Nigerian ethnic groups with a view understanding implication GST polymorphisms on disease susceptibility. Three hundred unrelated volunteers from Hausa, Ibo Yoruba who consented...
Aims Doxorubicin‐induced cardiotoxicity (DIC) is a significant cause of mortality in cancer care. This study was conducted to establish the frequency DIC Zimbabwean breast patients on doxorubicin and test predictive power genetic biomarkers. Methods A cohort 50 treated with were followed up for 12 months serial echocardiography genotyped UGTA1A6*4, SLC28A3 RARG. Eleven per cent experienced DIC. Results The frequencies (rs7853758), UGT1A6*4 (rs17863783) RARG (rs2229774) 60.7%, 17.9% 14.3%,...
Human genetics research and applications are rapidly growing areas in health innovations services. African populations reported to be highly diverse carry the greatest number of variants per genome. Exploring these is key realize genomic medicine initiative. However, grossly underrepresented various databases, which has alerted scientists address this issue with urgency. In Tanzania, human services conducted different institutions on both communicable noncommunicable diseases. there poor...
Abstract Of the 500 000 children born with sickle cell disease annually, most cases occur in Africa, contributing to significant morbidity and mortality associated limited (SCD) health outcomes data reduced access therapeutic plus preventive care. We aim develop manage a standardized electronic SCD registry, establish consistent standards of care (SoC) for patients, improve research biobanking capacity Zimbabwe Zambia. This five-year program employs mixed methods that include infrastructure...
Abstract Chloroquine/hydroxychloroquine have been proposed as potential treatments for COVID-19. These drugs warning labels use in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Analysis of whole-genome sequence data 458 from sub-Saharan Africa showed significant G6PD variation across the continent. We identified nine variants, which four are potentially deleterious to function, and one (rs1050828) that is known cause supplemented rs1050828 variant genotype array over...
Background: Pain is a common cause of hospitalization in sickle cell disease (SCD) patients. Failure to effectively control pain remains challenge patient care. Materials & methods: The authors conducted cross-sectional study determine the effect CYP2D6 and UGT2B7 polymorphisms on management 106 Zimbabwean SCD Participant information was collected questionnaire. Genotyping using GenoPharm® pharmacogenomics open array panel containing UGT genetic variants implicated opioid response. Results:...
Abstract Purpose Women living with HIV (WLWH) and breast cancer (BC) have worse overall survival than HIV-negative women BC, poor adherence to prescribed tamoxifen is known contribute survival. Methods Among 4,097 diagnosed at six hospitals in the prospective South African Breast Cancer Outcomes (SABCHO) cohort study between July 2015 December 2020, we focused on black stages I-III HR-positive who were 20mg of adjuvant daily. We analyzed concentrations its metabolites using a triple...