A5008410976- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Advances in Oncology and Radiotherapy
- Advanced Radiotherapy Techniques
- Palliative Care and End-of-Life Issues
- Estrogen and related hormone effects
- Viral-associated cancers and disorders
- Global Health and Surgery
- Inflammatory mediators and NSAID effects
- Cancer survivorship and care
- Family Support in Illness
- Management of metastatic bone disease
- Economic and Financial Impacts of Cancer
- Breast Cancer Treatment Studies
- Pharmacogenetics and Drug Metabolism
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Innovations in Medical Education
- Pediatric Pain Management Techniques
- Colorectal Cancer Screening and Detection
- Endometrial and Cervical Cancer Treatments
- Multiple and Secondary Primary Cancers
- Lymphoma Diagnosis and Treatment
- Pain Management and Opioid Use
- BRCA gene mutations in cancer
University of Zimbabwe
2016-2023
Parirenyatwa Hospital
2003-2023
University of Pretoria
2020
Ministry of Health and Child Welfare
2019
American Society of Clinical Oncology
2016
Incidence rates of different cancers have been calculated for the black population Harare, Zimbabwe a 20‐year period (1991–2010) coinciding with continuing social and lifestyle changes, peak, subsequent wane, HIV‐AIDS epidemic. The overall risk cancer increased during in both sexes, cervix prostate showing particularly dramatic increases (3.3% 6.4% annually, respectively). By 2004, had become most common men. incidence esophagus, formerly men, has remained relatively constant, whereas breast...
Cervical cancer is the most common and a major cause of morbidity mortality among women in Zimbabwe yet it preventable, early detectable highly curable. The objective this study was to investigate knowledge, attitudes, beliefs practices towards cervical cancer, its prevention treatment Harare, Zimbabwe. Sequential explanatory mixed methods approach consisting analytical cross sectional survey qualitative inquiry used. Study population consisted with health workers other stakeholders who are...
Abstract This paper provides the first comprehensive population based cancer survival estimates from African continent. Five‐year absolute and relative are presented for black white Zimbabwean patients diagnosed with in Harare, Zimbabwe between years 1993 1997. The of among lowest ever reported registries. For most sites, have much higher than Zimbabweans, except lung colorectal cancer, which similarly poor. Race specific comparisons to United States show that lower American gap is broader...
Cervical cancer is the most commonly diagnosed among women in Zimbabwe; however; access to screening and treatment services remain challenged. The objective of this study was investigate socio-demographic inequities cervical utilization Harare, Zimbabwe.Two cross sectional surveys were conducted Harare with a total sample 277 aged at least 25 years. In community survey, stratified random sampling select 143 healthy Glen View, Cranborne, Highlands Hopely communities present high, medium, low...
PURPOSE Hypofractionated breast radiotherapy has been found to be equivalent conventional fractionation in many clinical trials. Using data from the European Society for Radiotherapy and Oncology Global Impact of survey, we identified preferences hypofractionation cancer across World Bank income groups perceived facilitators barriers its use. MATERIALS AND METHODS An international, electronic survey was administered radiation oncologists 2018 2019. Demographics, practice characteristics,...
Abstract Background Cervical cancer is mostly diagnosed at advanced stages among the majority of women in low-income settings, with palliative care being only feasible form care. This study was aimed investigating knowledge and access cervical Harare, Zimbabwe. Methods Sequential mixed methods design used, consisting two surveys a qualitative inquiry. A census 134 who visited treating health facilities one provider Harare between January April, 2018 were enrolled study. Seventy-eight workers...
Abstract The survival experience of 284 patients with cancer the cervix uteri registered by population‐based Zimbabwe National Cancer Registry in 1995–1997 is described. vital status these subjects was established linkage death registration and retrieval patient files from medical records departments. Untraced were contacted at home. Of 284, 177 (62.3%) dead 76 (26.8%) alive closing date study (31 December 1999), only 31 cases (10.9%) lost to follow‐up. Overall observed relative 3 years...
Cervical cancer treatment and care services have remained largely centralized in Zimbabwe thereby entrenching inequities to access amongst patients. The objective of this study was investigate the determinants among women with cervical Harare, Zimbabwe.A sequential explanatory mixed methods design used. In phase 1, three surveys (namely community, patient health worker) were conducted sample sizes 143, 134 78 participants respectively. Validated structured questionnaires programmed Android...
Abstract Background Cervical cancer is a major cause of morbidity and mortality among women yet access to treatment care remains huge challenge in Zimbabwe. The objective this study was investigate health system constraints affecting engagement into by with cervical Harare, Methods A sequential explanatory mixed methods design used for study. Phase 1 comprised two surveys namely: patient worker sample sizes 134 78 participants respectively. Validated structured questionnaires programmed...
Abstract Tamoxifen is the most used hormonal therapy for oestrogen receptor‐positive breast cancer. CYP2D6 main enzyme in metabolic pathway of tamoxifen to endoxifen. Variations endoxifen plasma concentrations are associated with polymorphisms. This study aimed determine association between polymorphisms and a cohort Zimbabwean cancer patients ( n = 40). TaqMan genotyping copy number assays were done genotypes. metabolites quantitated using LC‐MS/MS. The population had high frequencies...
Abstract Background Breast cancer is the second most common among women in Zimbabwe. Patients face socioeconomic barriers to accessing oncology care, including radiotherapy. We sought understand patterns of care and adherence for with breast sub‐Saharan Africa (SSA) radiotherapy access. Methods A retrospective cohort was created evaluated at Parirenyatwa Hospital Radiotherapy Oncology Center (RTC) from 2014 2018. Clinical data were collected define care. Non‐adherence modeled as a binary...
Abstract Background Cervical cancer treatment and care remains limited in Zimbabwe despite the growing burden of disease among women. This study was aimed at investigating strategies to address barriers accessing by women with cervical Harare, Zimbabwe. Methods A qualitative inquiry conducted generate evidence for this study. Eighty-four (84) participants were purposively selected interviews participation focus group discussions. The from patients, caregivers health workers involved patients...
Background: Cervical cancer treatment and care services have remained largely centralized in Zimbabwe thereby entrenching inequities to access amongst patients. The objective of this study was investigate the determinants for cervical Harare, Zimbabwe. Methods: A sequential explanatory mixed methods design used. In phase 1, three surveys (namely community, patient health worker) were conducted with sample sizes 143, 134 78 participants respectively. Validated structured questionnaires...
Cervical cancer is the second most common and leading cause of cancer-related death in women sub-Saharan Africa. It estimated that more than 200 million females older 15 years are at risk this region. This paper highlights current burden cervical Africa, reviews latest clinical data on primary prevention, outlines challenges region, offers potential solutions to these barriers. Based factors, recommendations for prevention from African Cancer Working Group expert panel presented.
The burden of cancer in low- to middle-income countries is growing and expected rise dramatically while resources manage this disease remain inadequate. All authorities for the management recommend multidisciplinary care. Educational efforts by international organizations assist local professionals caring their patients tend have a lasting impact because they empower enhance skills. A course was designed American Society Clinical Oncology staff experts provide roadmap cross-specialty...
In sub-Saharan Africa, radiotherapy (RT) utilization and delivery patterns have not been extensively studied in patients with metastatic breast cancer.A retrospective cohort study of female cancer seen at Parirenyatwa Radiotherapy Centre Zimbabwe from 2014 to 2018 was conducted. Demographics, pathology, staging, treatment data were abstracted through chart review. Fisher's exact test chi-squared independence used compare proportions, independent two-sample t-tests means.Of 351 cancer, 152...
Background: In Zimbabwe, the hormone receptor status is not always available when patients with breast cancer are started on treatment. Aim: This study evaluated discordance of treatment approach in such patients, National Comprehensive Cancer Network (NCCN) guideline recommendations as reference standard these results eventually available. Setting: Female who presented to Parirenyatwa Central Hospital Radiotherapy and Oncology Centre a histological diagnosis cancer, managed between 1...
It is of serious concern that there a lack focus on pain management in patients with cancer Africa. Most present advanced disease diagnosis, experiencing moderate to severe and need palliative care. Integration oncology care recommended by European Society Medical Oncology (ESMO) the World Health Assembly resolution WHA67.19. At recent ESMO Summit Africa 2020, Pain Workshop was attended representatives from across A consensus reached escalate concerns about call make universal control, int...
Abstract Background Cervical cancer is the fourth most common amongst women globally and it accounts for many deaths among females in Zimbabwe. The objective of this midterm review was to measure progress cervical prevention control interventions Methods A mixed methods approach used review. Secondary data collected from programme documents, published grey literature. Primary six provinces, including Harare Metropolitan. Key informant interviews were conducted with officials relevant...
Tamoxifen is the most used hormonal therapy for estrogen receptor positive breast cancer. CYP2D6 main enzyme in metabolic pathway of tamoxifen to endoxifen. Variations endoxifen plasma concentrations are associated with polymorphisms. This study aimed determine association between polymorphisms and a cohort Zimbabwean cancer patients (n = 40). TaqMan genotyping copy number assays were done genotypes. metabolites quantitated using LC-MS/MS. The population had high frequencies reduced function...