A5045844684- Pharmacogenetics and Drug Metabolism
- Plant and animal studies
- Insect and Pesticide Research
- Inflammatory mediators and NSAID effects
- Bee Products Chemical Analysis
- Estrogen and related hormone effects
- Acute Lymphoblastic Leukemia research
- Neonatal Health and Biochemistry
- Genomics and Rare Diseases
- HIV/AIDS drug development and treatment
- Genetic Associations and Epidemiology
African Institute of Biomedical Science and Technology
2022-2023
Chinhoyi University of Technology
2023
Pharmacogenomics (PGx) is a clinically significant factor in the safe and efficacious use of medicines. While PGx knowledge abundant for other populations, there are scarce data on African populations little drug-gene interactions medicines used to treat diseases common Africa. The aim this study was custom-designed open array genotype actionable variants Zimbabwean population. This also identified some commonly drugs Zimbabwe associated genes involved their metabolism.A that covers 120...
Abstract Tamoxifen is the most used hormonal therapy for oestrogen receptor‐positive breast cancer. CYP2D6 main enzyme in metabolic pathway of tamoxifen to endoxifen. Variations endoxifen plasma concentrations are associated with polymorphisms. This study aimed determine association between polymorphisms and a cohort Zimbabwean cancer patients ( n = 40). TaqMan genotyping copy number assays were done genotypes. metabolites quantitated using LC‐MS/MS. The population had high frequencies...
Pharmacogenomic testing may be used to improve treatment outcomes and reduce the frequency of adverse drug reactions (ADRs). Population specific, targeted pharmacogenetics (PGx) panel-based methods enable sensitive, accurate economical implementation precision medicine. We evaluated analytical performance GenoPharm® custom open array platform which evaluates 120 SNPs across 46 pharmacogenes. Using commercially available reference samples (Coriell Biorepository) in-house extracted DNA, we...
Tamoxifen is the most used hormonal therapy for estrogen receptor positive breast cancer. CYP2D6 main enzyme in metabolic pathway of tamoxifen to endoxifen. Variations endoxifen plasma concentrations are associated with polymorphisms. This study aimed determine association between polymorphisms and a cohort Zimbabwean cancer patients (n = 40). TaqMan genotyping copy number assays were done genotypes. metabolites quantitated using LC-MS/MS. The population had high frequencies reduced function...