A5000879955- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- DNA Repair Mechanisms
- Science, Research, and Medicine
- Genetics, Bioinformatics, and Biomedical Research
- Genetic Associations and Epidemiology
- Cell Adhesion Molecules Research
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Epigenetics and DNA Methylation
- Global Cancer Incidence and Screening
- Glycosylation and Glycoproteins Research
- Nutrition, Genetics, and Disease
- Breast Cancer Treatment Studies
- Genomic variations and chromosomal abnormalities
- Reproductive Physiology in Livestock
- BRCA gene mutations in cancer
Mbeya University of Science and Technology
2021-2022
University of Dar es Salaam
2019-2022
Muhimbili University of Health and Allied Sciences
2019
Abstract Background Reproductive history and genetics are well‐known risk factors of breast cancer (BC). Little is known about how these interact to effect BC. This study investigated the association ten polymorphisms in DNA repair genes with BC susceptibility Tanzanian samples further analyzed between reproductive disease Methods A hospital‐based case–control 263 histopathological confirmed patients 250 age‐matched cancer‐free controls was carried out. Allelic, genotypic, haplotype analyses...
Background: During cancer growth, immunosuppressive microenvironment is created that enables tumour cells to evade an eliminative immune response and hence manage grow into malignancy. HLA-G, existing as either membrane-bound (mHLA-G) or soluble (sHLA-G) molecule thought be produced more by tumor cells. The +3142G/C polymorphism in HLA-G gene affects its expression, G allele considered a protective mutant associated with less expression of HLA-G. implication development has been reported...
Human genetics research and applications are rapidly growing areas in health innovations services. African populations reported to be highly diverse carry the greatest number of variants per genome. Exploring these is key realize genomic medicine initiative. However, grossly underrepresented various databases, which has alerted scientists address this issue with urgency. In Tanzania, human services conducted different institutions on both communicable noncommunicable diseases. there poor...
Abstract Background Recent epidemiological studies suggest that reproductive factors are associated with breast cancer (BC) molecular subtypes. However, these associations have not been thoroughly studied in the African populations. The present study aimed to investigate prevalence of BC subtypes and assess their association Tanzanian patients. Methods This hospital-based case-only cross-sectional consisted 263 histologically confirmed patients Tanzania. Clinico-pathological data,...
Genome-wide association studies (GWAS) have recently confirmed a strong of the 9p21.3 locus with Coronary Artery Disease (CAD) in different populations but no data has been reported for Tanzanian population. This study aimed to investigate harboring disease-causing hotspot variations CAD patients and their associations risk factors. 135 140 non-CAD were enrolled into study. Further biochemical analysis, genotyping assays performed by use qRT-PCR. The genotype allele frequencies rs1333049,...