A5037791386- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- GABA and Rice Research
- Cancer, Hypoxia, and Metabolism
- Stress Responses and Cortisol
- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Long-Term Effects of COVID-19
- Free Radicals and Antioxidants
- Graphene and Nanomaterials Applications
- T-cell and B-cell Immunology
- Nanotechnology research and applications
- Biochemical Analysis and Sensing Techniques
- Advancements in Transdermal Drug Delivery
- Virus-based gene therapy research
- melanin and skin pigmentation
- Vitamin C and Antioxidants Research
- Bacterial Infections and Vaccines
- Nanoparticles: synthesis and applications
- High Altitude and Hypoxia
- Advanced Drug Delivery Systems
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Reproductive tract infections research
African Institute of Biomedical Science and Technology
2023
Chinhoyi University of Technology
2023
Landmark University
2020-2022
Federal University of Technology Minna
2020
Owing to the urgent need for therapeutic interventions against SARS-coronavirus 2 (SARS-CoV-2) pandemic, we employed an in silico approach evaluate SARS-CoV-2 inhibitory potential of newly synthesized imidazoles. The potentials compounds drug targets - main protease (Mpro), spike protein (Spro) and RNA-dependent RNA polymerase (RdRp) were investigated through molecular docking analysis. binding free energy protein-ligand complexes estimated, pharmacophore models generated absorption,...
Fluoropyrimidines are commonly used in the treatment of colorectal cancer. They are, however, associated with adverse events (AEs), which gastrointestinal, myelosuppression and palmar-plantar erythrodysesthesia most common. Clinical guidelines for fluoropyrimidine dosing based on dihydropyrimidine dehydrogenase (DPYD) genetic polymorphism have been shown to reduce these AEs patients European ancestry. This study aimed evaluate, first time, clinical applicability a cohort cancer standard care...
Melanin is s most widely distributed pigment and found in bacteria, fungi, plants, animals. Melanogenesis under complex regulatory control by multiple agents interacting through pathways activated hormonal receptor-dependent -independent mechanisms. There are about 20 genes that involved the biochemical pathway of melanogenesis its regulation, which include: tyrosinase, microphthalmia-associated transcription factor, melanocortin1 receptor, adenylate cyclase, protein kinase A. Human proteins...
The challenges of SARS-CoV-2 have frightened the world due to a lack effective treatment. Many clinicians adopted drug repositioning because urgent need contain viral pandemic. Several studies demonstrated in vitro and vivo antiviral efficacy chloroquine hydroxychloroquine treatment SARS-CoV-2. However, cardiovascular toxicity stand as limitation their general use treat Thus, it is necessitated search for an adjuvant that could be used alongside these treatments mitigate undesired effect....
Silver nanoparticles are increasingly being used in a wide variety of ways that may lead to frequency exposure for humans and the environment. Thus, it is necessary understand biological effect(s) these nanoparticles. Previously, we showed AgNPs activated kynurenine pathway rat brain independently oxidative stress rats. This present study aimed at evaluating effect on some selected cytokines, redox parameters, level Male Wistar rats (130‐150 g) were divided into 4 groups. Rats grouped...
Hypoxia-inducible factors (HIFs) are transcription that initiate the expression of cellular processes to cope with hypoxic conditions. HIFs principal regulators adaptation, regulating gene involved in glycolysis, erythropoiesis, angiogenesis, proliferation, and stem cell function under low O 2 . may play a pivotal role tumor survival metastasis cancer formation growth. Likewise, key microbial pathogenesis, particularly host-pathogen interaction. Because HIF-1alpha plays biology infections,...