A5051811691- Cannabis and Cannabinoid Research
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Cholinesterase and Neurodegenerative Diseases
- GABA and Rice Research
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Vitamin K Research Studies
- Protein Tyrosine Phosphatases
- Ginkgo biloba and Cashew Applications
- Cassava research and cyanide
- Medicinal Plant Extracts Effects
- Papaya Research and Applications
- Drug-Induced Hepatotoxicity and Protection
- Transgenic Plants and Applications
- Prenatal Substance Exposure Effects
- Moringa oleifera research and applications
- Heavy Metal Exposure and Toxicity
- Medicinal Plants and Neuroprotection
- Poisoning and overdose treatments
- Environmental Toxicology and Ecotoxicology
- Rabbits: Nutrition, Reproduction, Health
- SARS-CoV-2 and COVID-19 Research
- Vitamin C and Antioxidants Research
- Phytoestrogen effects and research
Federal University of Agriculture
2020-2023
McPherson University
2022
Ekiti State University
2020
Landmark University
2020
Neurodegenerative diseases, for example Alzheimer’s, are perceived as driven by hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, flavonoids, documented in studies having the ability to pass blood-brain barrier moderate development of such illnesses. Computer-aided drug design (CADD) has achieved importance discovery world; innovative developments aspects structure identification characterization, bio-computational science, molecular biology have added...
The management of diabetes over the years has involved use herbal plants, which are now attracting interest. We assessed antidiabetic properties aqueous extract
The purpose of this study was to investigate the therapeutic activity cinnamic acid derivative KAD-3 (ethyl 3-(4-methoxyphenyl) acrylate) on Fe2+-induced oxidative hepatic damage via experimental and computer aided studies. Oxidative induced incubation tissue supernatant with 0.1 mM FeSO4 for 30 min at 37 °C ex vivo different concentration KAD-3. Molecular docking, ADMET profiling, density functional theory were conducted candidate filter properties drug design. GSH, CAT, ENTPDase activities...
Consumption of water polluted by crude oil is a major environmental problem typical in exploration areas. Numerous health complications such as high blood pressure, myocardial infarction, and other heart are prevalent ravaging. These have gradually become age-defiling disease conditions that usually maintained with lifestyle changes diet control. The effect dietary supplementation 10% 20% roasted cashew nuts (RCN) on systolic pressure angiotensin converting enzyme I (ACE I) activities mixed...
Abstract Humans are daily exposed to 7,12‐dimethylbenz(a)anthracene (DMBA), a well known polycyclic aromatic hydrocarbons (PAH). This study investigated the role of dietary intake Vitamin K (VK), polyphenolic compound, with potential antioxidative properties, against DMBA‐induced hepatotoxicity. Sixty experimental animals (120‐150 g) were divided into six groups (A‐F): Control, DMBA (80 mg/kg bw) only, VK (0.00 g/10 kg) diet (7.5 + (0.0 and diet. Single oral administration body weight)...
Abstract SARS-CoV-2 a single stranded RNA virus which triggered the global pandemic Coronavirus Disease- 2019 (COVID-2019). It has infected about 2,844,712 patients and brought forth mortality rate to 201,315 among 216 countries as cited by WHO. Drugs including Chloroquine Hydroxychloroquine derivatives are being administered in most urgent cases; although, with probable side effects people metabolic disorders. Thus, unavailability of authorized drugs treatment for this demands research...
Medicinally, cannabis is gaining popularity and acceptance around the world despite public concerns regarding its legality. The wide range of phytochemical found in Cannabis sativa (C. sativa) plant predisposes it to use treatment a ailments or complications existing diseases. purpose this study was compare efficacy some reported phytochemicals hemp against three male fertility-associated proteins: testis expressed protein 11 (TEX 11), cation channel sperm associated 1 (CatSper 1),...
This study aimed to examine the therapeutic activity of cinnamic acid derivative KAD-7 (N'-(2,4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe2+-induced oxidative hepatic injury via experimental and computational models. In addition, role ATPase ectonucleoside triphosphate diphosphohydrolase (ENTPDase) in coordination cellular signals is speculated upon proffer suitable therapeutics for metabolic stress disorder their inhibition. While we know little about with flexible dual...
The gene expression of serotonin 5-hydroxytryptamine receptor 3A (receptor 3A:HTR3A) as well the concentration electrolytes in male Wistar rats after administration graded doses marijuana extract was investigated. Twelve groups (3 control and 9 test groups) 6 animals each were daily exposed to 12.5, 25 50 mg/kg b.w petroleum ether for 4, 8 12 weeks. expressions obtained using reverse transcriptase-polymerase chain reaction (RT-PCR) while concentrations determined. An upregulation over 90%...
Abstract One of the well‐known toxicants mammary tissue is 7,12‐dimethylbenz[a]anthracene (DMBA). This study was carried out to investigate possible prophylactic's role increased dietary intake vitamin K on induction toxicity in lung tissue. Twenty‐eight Wistar albino rats (120‐150 g) were randomly divided into different groups. Group 1 served as control and fed with a normal diet (containing recommended daily allowance (0.0075%)). Groups 2 3 received single dose DMBA (80 mg/kg body weight)...
Cannabis and cannabinoids affect almost every system of the body exert systemic effects such as alterations in memory cognitive functions, neurotransmission impediment, well obstruction endocrine reproductive functions. Reproduction is a complicated phenomenon that integrates biological, psychological behavioural aspects, hence susceptible to intracellular extracellular modulations by numerous chemicals toxicants like cannabis.The early-life exposure cannabis on function biomarkers genes...
Protein tyrosine phosphatase 1B (PTP1B) has been identified as a promising drug target for the development of diabetes medications via an inhibition mechanism. Using computational approach, this study investigates binding mechanism lead optimized natural compounds from Allium sativum against human PTP1B. The molecular docking, induced-fit and free energy calculations were analyzed using Schrödinger Suite 2021-2. MD simulation, gene enrichment analysis was achieved Desmond module to identify...
This study examined the probable effects of graded doses Cannabis sativa (C. sativa) extract on gene expressions monoamine oxidase B and serotonin receptor 2C (HTR2C) in an attempt to correlate duration use with neurodegeneration tendencies chronic marijuana users. Male Wistar rats weighing between 90 g ± 100 were treated petroleum ether C. (12.5, 25 50 mg/kg body weight) orally. The exposure was monitored at 4, 8, 12 weeks for each employed, after which brain removed. determined by reverse...
Automobile repair workshops contribute immensely to the generation of soil and water contamination. This study was conducted compare microbial load, heavy metals, consequent toxicological effects, in three (3) automobile mechanic sites.Soil samples were randomly collected from 3 different auto workshop Abeokuta town Ogun-State, Nigeria. Bacterial fungal counts done via standard procedures. High-performance liquid chromatography employed for aflatoxin quantification. Also, 24 Wistar rats...