A5040283872- Nanoparticles: synthesis and applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Computational Drug Discovery Methods
- Medicinal Plants and Neuroprotection
- Nanoparticle-Based Drug Delivery
- Moringa oleifera research and applications
- Biochemical and Structural Characterization
- Biosensors and Analytical Detection
- Synthesis and biological activity
- Wound Healing and Treatments
- Essential Oils and Antimicrobial Activity
- Organometallic Compounds Synthesis and Characterization
- Antimicrobial Peptides and Activities
- Crystal structures of chemical compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Quantum Dots Synthesis And Properties
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Toxin Mechanisms and Immunotoxins
- Magnetism in coordination complexes
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
University of the Western Cape
2016-2025
Mintek
2016-2025
Cape Peninsula University of Technology
2022
City of Cape Town
2020-2021
Bell (Canada)
2021
Medical Research Council
2015
University of Limpopo
2007
Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes and is potentially capable of enhancing this infection. Although vaccination believed induce durable protective responses all the dengue virus (DENV) in order reduce burden posed virus, development safe efficacious vaccine remains challenge. Immunoinformatics computational...
New palladium (Pd)II and platinum (Pt)II complexes (C1–C5) from the Schiff base ligands, R-(phenyl)methanamine (L1), R-(pyridin-2-yl)methanamine (L2), R-(furan-2-yl)methanamine (L3) (R-(E)-N-((1H-pyrrol-2-yl) methylene)) are herein reported. The were characterized by FTIR, 1H 13C NMR, UV–vis, microanalyses. Single-crystal X-ray crystallographic analysis was performed for two ligands (L1–L2) a Pt complex. Both L1 L2 belong to P21/n monoclinic P-1 triclinic space systems, respectively. complex...
Abstract Chronic wounds continue to pose severe threats public health and the global economy. This is because healing process hindered by several factors, such as bacterial infections, comorbid conditions, age, lifestyle. Medical wound therapy currently based on long-term antibiotic use, its activity has been limited various including treatment efficacy, toxicity, increased risk of opportunistic infections. The advent novel techniques nanotechnology can provide sustainable platforms for...
A detailed, methodical approach was used to synthesise silver and gold nanoparticles using two differently prepared aqueous extracts of the brown algae
The global increase in outbreaks and mortality rates associated with multi-drug-resistant (MDR) bacteria is a major health concern calls for alternative treatments. Natural-derived products have shown potential combating the most dreadful diseases, therefore serve as an effective source of bioactive compounds that can be used anti-bacterial agents. These are able to reduce metal ions cap nanoparticles form biogenic (NPs) remarkable activities. This study explores use Terminalia mantaly (TM)...
Green nanotechnology has drawn major attention because of its ecofriendly and economical biosynthetic protocols. Synthesis gold nanoparticles (AuNPs) using plant secondary metabolites is considered as a safer cheaper option. Plants contain phytochemicals that been used traditionally for treatment various diseases, proved to be non-toxic healthy tissues. These play an important role in bio-reduction processes reducing stabilizing agents, renders NPs selective toxicity towards diseased The...
Silver nanoparticles (AgNPs) are the most commercialized nanomaterials and presumed to be biocompatible based on biological effects of bulk material. However, their physico-chemical properties differ significantly materials associated with unique properties. The study investigated antimicrobial cytotoxicity AgNPs synthesized using gum arabic (GA), sodium borohydride (NaBH
Scientists have demonstrated the potential of plant materials as ‘green’ reducing and stabilizing agents for synthesis gold nanoparticles (AuNPs) opened new ecofriendly horizons to develop effective less harmful treatment strategies. The current study use Terminalia mantaly (TM) extracts synthesize AuNPs with enhanced cytotoxic effects. TM-AuNPs were synthesized at 25 70 °C using water (WTM) methanolic (MTM) leaf, root stem/bark parts plant. characterized UV–visible spectrophotometry,...
Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported have numerous biological activities, including anti-tumor activity. MGF and extracts contain concentrations MGF, such as from Mangifera indica L. or mango been synthesize gold nanoparticles (AuNPs) using green nanotechnology. It has previously shown when AuNPs synthesized M. are...
There is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to control and prevent dental diseases. The incorporation AgNPs into dentifrices reduce pathogenic oral microbes motivated by their presumed biocompatibility broad-spectrum antimicrobial activity. In present study, gum arabic (GA-AgNPs) were formulated a toothpaste (TP) using commercial TP at non-active concentration, produce GA-AgNPs_TP. was selected after evaluating activity four TPs 1-4 on agar disc...
Disposal of agricultural waste has a negative impact on the environment and human health may contribute to greenhouse effect. The field nanotechnology could provide alternative solutions upcycle wastes in safer manner into high-end value products. Organic from plants contain biomaterials that serve as reducing capping agents synthesis nanomaterials with enhanced activities for use biomedical environmental applications. Persea americana (avocado) is fruit high nutritional value; however,...
Severe protein clumping in the lens can block light and lead to vision issues cataract patients. Recent studies have linked β-crystallins, which are key proteins lens, development of cataracts. Specifically, S175G/H181Q mutation βB2-crystallin gene plays a major role formation. To understand how this be activated, we utilized computational methods predict activators from Phaseolus vulgaris. The Schrödinger platform was employed screen bioactive compounds simulate molecular interactions order...
Abstract The increasing incidence of antimicrobial resistance (AMR) poses a serious threat to public health, which necessitates the development alternative countermeasures combat it. Green nanotechnology, in particular use silver nanoparticles (AgNPs), shows promise combating AMR. Although synthesis AgNPs using medicinal plant extracts has been explored, combining from two plants synthesize with enhanced properties received less attention. Therefore, this study addresses gap by presenting...
The use of natural products as chemotherapeutic agents is well established; however, many these are associated with undesirable side effects, including high toxicity and instability. Furthermore, the development drug resistant cancers makes search for new anticancer lead compounds a priority. In this study, extraction an Ircinia sp. sponge resulted in isolation inseparable mixture (7E,12E,20Z)-variabilin (1) (7E,12Z,20Z)-variabilin (2) structural assignment was established using standard 1D...
The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs treat this infection. Using silico molecular docking approaches, study investigated the inhibitory effects Pradimicin A, Lamivudine, Plerixafor Lopinavir against SARS-CoV-2 Mpro. ADME/Tox ligands, pharmacophore hypothesis co-crystalized ligand receptor, studies were carried out on different modules Schrodinger (2019-4) Maestro v12.2. Among ligands subjected by QikProp,...