A5019376654- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- vaccines and immunoinformatics approaches
- Pneumonia and Respiratory Infections
- interferon and immune responses
- Bacteriophages and microbial interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 and healthcare impacts
- RNA and protein synthesis mechanisms
- Bacillus and Francisella bacterial research
- Monoclonal and Polyclonal Antibodies Research
- Diet and metabolism studies
- Bioactive Compounds in Plants
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Infrared Thermography in Medicine
- Viral Infections and Outbreaks Research
- Natural product bioactivities and synthesis
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Biochemical and Structural Characterization
- SARS-CoV-2 detection and testing
- Natural Compounds in Disease Treatment
- Venous Thromboembolism Diagnosis and Management
University of the Western Cape
2019-2024
Mintek
2019-2024
South African Medical Research Council
2021-2024
South African National Biodiversity Institute
2024
Osakidetza
2021
Hospital Santiago Apostol
2021
Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes and is potentially capable of enhancing this infection. Although vaccination believed induce durable protective responses all the dengue virus (DENV) in order reduce burden posed virus, development safe efficacious vaccine remains challenge. Immunoinformatics computational...
Ebola viral disease (EVD) is a highly infectious and potentially fatal illness with case fatality rate ranging from 25% to 90%. To effectively control its spread, there need for rapid, reliable lowcost point-of-care (P OC) diagnostic tests. While various EVD tests exist, few are P OC tests, many not cost-effective. The use of antibodies in these has limitations, prompting the exploration aptamers as potential alternatives. Various proteins virus (EBOV) proteome, including EBOV nucleoprotein...
The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but rate at which they are being administered slow in several countries, and mutations could render them less effective. Moreover, remdesivir seems to work only with some types COVID-19 patients. Hence, continuous investigation new treatments this disease pivotal. This study investigated inhibitory role natural products against Mpro repurposable...
Abstract Background HIV-1 produces Tat, a crucial protein for transcription, viral replication, and CNS neurotoxicity. Tat interacts with TAR, enhancing HIV reverse transcription. Subtype C variants (C31S, R57S, Q63E) are associated reduced transactivation neurovirulence compared to subtype B. However, their precise impact on Tat-TAR binding is unclear. This study investigates how these substitutions affect interaction. Methods We utilized molecular modelling techniques, including MODELLER,...
The estimated prevalence of diabetes in Kenya is around 2.2%. There a lack awareness on Kenya, leading to delayed diagnosis and management. This hinders early intervention control the disease. adoption more Westernized diet, which often high processed foods low nutritional value, coupled with decrease physical activity, has contributed rise cases. Access affordable medications, regular blood glucose testing, specialized care can be challenging for many Kenyans. lead inadequate glycemic...