Raphael Taiwo Aruleba
A5029068222- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Computational Drug Discovery Methods
- Mitochondrial Function and Pathology
- Climate Change and Health Impacts
- ATP Synthase and ATPases Research
- Global Maternal and Child Health
- Antimicrobial Peptides and Activities
- Global Health Care Issues
- vaccines and immunoinformatics approaches
- Natural Antidiabetic Agents Studies
- Oral Health Pathology and Treatment
- COVID-19 and healthcare impacts
- Health disparities and outcomes
- Helminth infection and control
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Enzyme function and inhibition
- COVID-19 Clinical Research Studies
Atrium Health Wake Forest Baptist
2025
Institute for Health Metrics and Evaluation
2022-2024
University of Washington
2022-2024
East Carolina University
2023-2024
University of Cape Town
2020-2023
Veterans Health Administration
2022
University of Zululand
2017-2021
Diabetes is one of the leading causes death and disability worldwide, affects people regardless country, age group, or sex. Using most recent evidentiary analytical framework from Global Burden Diseases, Injuries, Risk Factors Study (GBD), we produced location-specific, age-specific, sex-specific estimates diabetes prevalence burden 1990 to 2021, proportion type 1 2 in attributable selected risk factors, projections through 2050.
Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated number deaths associated with drug-resistant infections and sepsis found that remain a leading cause globally. Understanding common bacterial pathogens (both susceptible resistant antimicrobials) essential identify greatest threats health. To our knowledge, this first study present comprehensive estimates 33 across 11 major infectious syndromes.
Detailed, comprehensive, and timely reporting on population health by underlying causes of disability premature death is crucial to understanding responding complex patterns disease injury burden over time across age groups, sexes, locations. The availability estimates can promote evidence-based interventions that enable public researchers, policy makers, other professionals implement strategies mitigate diseases. It also facilitate more rigorous monitoring progress towards national...
Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets disease mitigation. We describe the prevalence, years lived with disability, and trends its underlying causes in 204 countries territories.We estimated population-level distributions haemoglobin concentration by age sex each location from 1990 2021. then calculated severity associated disability (YLDs). With data on...
<h2>Summary</h2><h3>Background</h3> The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these is issue of financing national especially low-income middle-income countries (LMICs), as well a robust global system for preparedness. We aimed provide comparative assessment spending at onset pandemic; characterise amount development assistance preparedness response disbursed first 2 years...
The global burden of lower respiratory infections (LRIs) and corresponding risk factors in children older than 5 years adults has not been studied as comprehensively it younger years. We assessed the trends LRIs across all age groups by sex, for 204 countries territories.
A critical and persistent challenge to global health modern care is the threat of antimicrobial resistance (AMR). Previous studies have reported a disproportionate burden AMR in low-income middle-income countries, but there remains an urgent need for more in-depth analyses across Africa. This study presents one most comprehensive sets regional country-level estimates bacterial WHO African region date.
<h2>Summary</h2><h3>Background</h3> Global evaluations of the progress towards WHO End TB Strategy 2020 interim milestones on mortality (35% reduction) and incidence (20% have not been age specific. We aimed to assess global, regional, national-level burdens trends in tuberculosis its risk factors across five separate groups, from 1990 2021, report age-specific between 2015 2020. <h3>Methods</h3> used Burden Diseases, Injuries, Risk Factors Study 2021 (GBD 2021) analytical framework compute...
Presently, many studies have focused on exploring in silico approaches the identification and development of alternative therapy for treatment management cancer. Solute carrier family-2-member-4-gene (Slc2a4) which encodes glucose transporter 4 protein (GLUT4), has been identified as a promising therapeutic target Though Slc2a4 is known to play major regulatory role pathophysiology type 2 diabetes, emerging evidence suggests that successful pharmacological inhibition this may lead novel drug...
The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs treat this infection. Using silico molecular docking approaches, study investigated the inhibitory effects Pradimicin A, Lamivudine, Plerixafor Lopinavir against SARS-CoV-2 Mpro. ADME/Tox ligands, pharmacophore hypothesis co-crystalized ligand receptor, studies were carried out on different modules Schrodinger (2019-4) Maestro v12.2. Among ligands subjected by QikProp,...
The burden of human schistosomiasis, a known but neglected tropical disease in Sub-Saharan Africa, has been worrisome recent years. It is becoming increasingly difficult to tackle schistosomiasis with praziquantel, drug be effective against all Schistosoma species, due reports reduced efficacy and resistance. Therefore, this study seeks investigate the antischistosomal potential phytochemicals from Azadirachta indica proteins that have implicated as druggable targets for treatment using...
OxPhos inhibitors have struggled to show a clinical benefit because of their inability distinguish healthy from cancerous mitochondria. Herein, we describe an actionable bioenergetic mechanism unique acute myeloid leukemia (AML) Unlike cells that couple respiration ATP synthesis, AML mitochondria support inner-membrane polarization by consuming ATP. Matrix consumption allows survive stress. Thus, hypothesized may resist chemotherapy-induced cell death reversing the synthase reaction. In...
Major histocompatibility complex class 1 chain-related gene sequence A is a polymorphic found at about 46.6 kb centromeric to HLA-B. It encodes transmembrane protein, which non-classical human leukocyte antigen whose expression normally induced by stress conditions like cancer and viral infections. The of MIC-A leads the activation NKG2D receptors natural killer T cells, leading generation innate immune response that can easily eliminate/cleanse tumour cells other express protein. Several...
The worldwide expanding increment in cancer pervasiveness is disturbing and this disease ranks among the main causes of mortality both developing developed countries. Unfortunately, available treatment options come with serious side effects do not guarantee complete success. Although numerous models have been proposed for development better therapeutic agent, however exact mechanism are still poorly understood. This then calls continued research aimed at new drugs as an alternative or...
In recent years, there has been an exponential increase in the global burden of cancer which associated with several factors including environmental influence, aging, diet, infectious agents, hormonal imbalance and chronic inflammation, among others. Cancerous cells utilize more glucose for its proliferation survival than normal cells. Thus, regulation consumption cancerous through inhibition transporter-4-protein (GLUT4) encoded by solute carrier family-2-member-4-gene (Slc2a4) selected...
Schistosomiasis is an infectious tropical disease caused by parasitic flatworm of the genus Schistosoma. This debilitating chronically infects about 200 million people globally and management relies on chemotherapy. Unfortunately, solely available schistosomicide (praziquantel) against all forms adult schistosmes has been faced with numerous drawbacks. Thus, there urgent need to design develop a new regimen for schistosomiasis. In light this, current study focuses inhibiting schistosome...
Lignin recalcitrance is a key issue in producing value-added products from lignocellulose biomass. In situ biodegradable lignin-modifying enzymes-producing bacteria are considered suitable solution to lignin biodegradation problems, but exploitation of ligninolytic still limited date. Hence, this study aimed isolate and characterize potential peroxidase decomposing soil, sawdust, cow dung at Richard Bay, South Africa. The samples were collected cultured the lignin-enriched medium. Pure...