In recent years, indigenous medicinal plants exhibiting diverse biological activities have been explored in the amelioration of hepatotoxicity. This study investigates protective effect Monodora myristica (MM) on cadmium-induced liver damage experimental animals. Male Wistar albino rats were maintained 200 mg/L cadmium: Cd (Cd as CdCl2) animals' main drinking water to induce Added this, animals received aqueous extracts MM at a dose or 400 and 20 mg/kg bw Livolin forte (LF) for 21 days. At...

Currently, there is no known cure for diabetes. Different pharmaceutical therapies have been approved the management of type 2 diabetes mellitus (T2DM), some are in clinical trials and they classified according to their route or mechanism action. Insulin types, sulfonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones, meglitinides, sodium–glucose cotransporter incretin-dependent (glucagon-like peptide-1 receptor agonists: GLP-1R, dipeptidyl peptidase 4 inhibitors: DPP-4)....

Abstract The use of plant‐derived foods in the prevention, treatment, and management metabolic diseases especially diabetes has gained prominence; this been associated with their physicochemical properties. This study was conducted to compare proximate, functional, mineral, antinutrient composition fermented seeds, defatted protein isolate from Parkia biglobosa seeds. results showed that fermented, defatted, varied within parameters studied. proximate analysis revealed had highest ash (6.0%)...

Lignin recalcitrance is a key issue in producing value-added products from lignocellulose biomass. In situ biodegradable lignin-modifying enzymes-producing bacteria are considered suitable solution to lignin biodegradation problems, but exploitation of ligninolytic still limited date. Hence, this study aimed isolate and characterize potential peroxidase decomposing soil, sawdust, cow dung at Richard Bay, South Africa. The samples were collected cultured the lignin-enriched medium. Pure...

Synthetic and untreated dyes discharged in wastewater effluents are a threat to an ecosystem. This study investigated dye degradation detoxification efficiency of crude lignin peroxidase separately obtained from the cultures Escherichia coli (LR0250096.1) Pseudomonas aeruginosa (CP031449.2). The ability degrade Malachite Green (MG), Remazol Brilliant Blue R (RBBR), Congo Red (CR), Azure B (AZ) was evaluated at different operating conditions (enzyme, dye, hydrogen peroxide concentrations; pH;...

This study seeks to investigate the possible protective role of methanol extract Piper guineense seeds against CCl₄-induced hepatotoxicity in an animal model. Hepatotoxicity was induced by administering oral doses CCl₄ (1.2 g/kg bw) three times a week for weeks. Group 1 (Control) and 2 (CCl₄) were left untreated; (PG; 400 mg/kg administered 3 (T₁) gavage 14 days prior administration simultaneously with CCl₄; PG (400 4 (T₂); Livolin forte (20 5 (T₃), standard drug group. The induces...

This study sought to investigate the possible protective role of Parkia biglobosa seed protein isolate (PBPi) against streptozotocin-induced hepatic damage and oxidative stress in diabetic male rats. Prior animal experiments, a HPLC fingerprint PBPi was recorded. Diabetes induced rats by single intraperitoneal injection streptozotocin (STZ; 60 mg/kg body weight). Diabetic were orally treated daily with (200 or 400 weight) insulin (5 U/kg, i.p.) for 28 days. The degree protection evaluated...

Type 2 diabetes remains one of the leading causes death worldwide. Persistent hyperglycemia within a diabetic state is implicated in generation oxidative stress and aggravated inflammation that responsible for accelerated modification pancreatic beta cell structure. Here we investigated whether lanosteryl triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA-3), isolated from Protorhus longifolia can improve glucose tolerance ultrastructure by reducing high fat diet...

Essential oil hydrodistilled from the leaves of Croton gratissimus was analyzed by gas chromatography (GC) and chromatography-mass spectrometry (GC-MS) to identify constituents comparison their mass spectra (MS) data linear retention indices (LRI) with literature. Forty corresponding 96.7% total content were identified sample. The major compounds sabinene (14.6%), α-phellandrene (12.3%), β-phellandrene (10.7%), α-pinene (6.05%), germacrene D (5.9%). essential exhibited stronger antibacterial...

Cyanobacteria in recent times have been touted to be a suitable source for the discovery of novel compounds, including antioxidants and antibiotics, due their large arsenal metabolites. This study presents vitro antioxidant silico evaluation Cylindrospermum alatosporum NR125682 Loriellopsis cavenicola NR117881, isolated from freshwater ponds around campus University Zululand, South Africa. The isolates were confirmed using 16S rRNA. Various crude extracts microbes prepared through sequential...

Background: Acacia senegal (Fabaceae) Wild is a leguminous tree with economic values, but its leaves are under-utilised. Objective: To investigate the phytochemical constituents and antioxidant potential of crude extracts from A. Senegal's leaves. Methods: Methanol acetone were prepared by maceration using organic solvents, methanol respectively. Qualitative quantitative analysis evaluated Association Agricultural Chemist (AOAC) protocols. Antioxidant activities determined 2,...

Alzheimer's disease (AD) is the most common form of dementia and constitutes fifth leading cause mortality across globe. Available treatment modalities drugs have abysmally failed to curtail AD. This study evaluated mitigation Aβ aggregation anti-cholinesterase activities with crude extracts Ptaeroxylon obliquum Bauhinia bowkeri. Computational studies abundant phytochemicals from both plants proteins were investigated. The phytochemical composition different (hexane, DCM, ethanol) analyzed...

Purpose: To investigate the antithrombotic, anticoagulant and antiplatelet activity of betulinic acid (BA) 3β-acetoxybetulinic (BAA) from Melaleuca bracteata 'Revolution Gold'.Methods: Betulinic was isolated ethyl acetate extract M. leaves by column chromatography, which BAA subsequently synthesized acetylation. Structural elucidation compounds conducted using mass spectrometry (MS), infra-red (IR) spectroscopy nuclear magnetic resonance (NMR). The antithrombotic potential assessed...

Reports from previous studies now provide evidence that dyslipidaemia and oxidative stress play crucial roles in the pathogenesis progression of diabetes its related complications. This research is aimed to investigate potential effects protein isolate Parkia biglobosa seeds (PBPI) streptozotocin (STZ)-induced diabetic rats by measuring blood glucose levels, changes lipid metabolism biomarkers stress. Diabetic were treated orally with graded doses PBPI, 200 mg/kg bw 400 bw, 5 U/kg,...

Considering the global health threat posed by kidney disease burden, a search for new nephroprotective drugs from our local flora could prove powerful strategy to respond this threat. In study we investigated antihyperuricemic and potential of RA-3, plant-derived lanosteryl triterpene. The effect RA-3 was using adenine gentamicin induced hyperuricemic nephrotoxicity rat model. Following induction hyperuricemia nephrotoxicity, experimental model rats (Sprague Dawley) were orally administered...

Background: Diabetes mellitus has been identified as one of the global cause disability and death. Objectives: The study aim to investigate in-vitro antidibetic antioxidant activities methanolic extract Encephalartos ferox leaves. Materials Methods: plant was screened for its Phytochemical composition. material extracted with methanol (in-vitro) activity using ABTS DPPH assays. potential antidiabetic evaluated against some carbohydrates (α- amylase α-glucosidase) lipid (pancreatic lipase)...

Purpose: To evaluate the anti-oxidant, anti-inflammatory and anti-acetylcholine esterase activities of betulinic acid (BA) 3β- acetoxybetulinic (BAA) from Melaleuca bracteata. ‘Revolution Gold’.Methods: Betulinic was isolated ethyl acetate extract M. braceteata while BAA synthesized by acetylation BA. Structural elucidation compounds achieved spectroscopic methods. Antioxidant potential determined using superoxide dismustase (SOD) catalase assay kits iron chelation activity assessed with...

Background: Oxidative stress is implicated in most life threaten diseases. Objectives: This study evaluated the phytochemical constituents and antioxidant activity of Lippia javanica's crude extracts. Methods: Phytochemical screening was carried out on pulverized javanica leaves using standard protocols. Crude extracts were prepared various solvents (hexane, acetone, ethylacetate, methanol, dichloromethane respectively), percentage yields calculated. The activities monitored with DPPH, ABTS...

Protein isolate from Parkia biglobosa seeds is believed to possess excellent anti-diabetic properties. The purpose of this study was identify differentially expressed proteins in liver streptozotocin-induced diabetic rats treated with protein (PBPi). In study, total extracted rat were separated on one-dimensional SDS polyacrylamide gel (1D SDS-PAGE) and stained Coomassie brilliant blue (CBB) visualize bands. We observed that bands the region 10-15 kDa altered by different treatments; these...

Diabetes mellitus remains a global health issue despite the advance in orthodox medicine. This study investigated vitro antioxidant and antidiabetic potential of crude extracts from seed coat pulp Strychnos madagascariensis. The phytochemical screening was carried out using standard protocols. Different were prepared fruit parts by maceration methanol, n-hexane, ethyl acetate, water for assays, their percentage yield calculated. determined 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic...