A5029887767- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Diet, Metabolism, and Disease
- Cholinesterase and Neurodegenerative Diseases
- Moringa oleifera research and applications
- Medicinal Plants and Neuroprotection
- SARS-CoV-2 and COVID-19 Research
- Hibiscus Plant Research Studies
- African Botany and Ecology Studies
- Heavy Metal Exposure and Toxicity
- Parasites and Host Interactions
- Ginger and Zingiberaceae research
- Sesame and Sesamin Research
- Piperaceae Chemical and Biological Studies
- Bioactive natural compounds
- Free Radicals and Antioxidants
- Phytochemicals and Medicinal Plants
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Metabolism, Diabetes, and Cancer
- Phytochemical and Pharmacological Studies
- Pharmacological Effects of Medicinal Plants
- Essential Oils and Antimicrobial Activity
University of Zululand
2016-2025
Afe Babalola University
2016-2025
Adekunle Ajasin University
2024
University of Cambridge
2023
Babcock University
2023
Federal University Oye Ekiti
2023
University of the Western Cape
2019-2023
International Islamic University Malaysia
2023
Valens Clinics
2023
London School of Hygiene & Tropical Medicine
2021
The treatment of diabetes involves the use herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract Persea americana seeds (AEPAS) was explored this study as a possible therapeutic agent rats with mellitus. induction achieved by injecting 65 mg/kg body weight (BWt) alloxan along 5% glucose. This conducted using thirty-six (36) male Wistar rats. animals were divided into 6 equal groups, (n = 6) treated for 14 days. In vitro assays total flavonoid,...
The increasing global burden of diabetes mellitus has called for the search a therapeutic alternative that offers better activities and safety than conventional chemotherapy. Herein, we evaluated neuroprotective antioxidant properties different fractions (ethyl acetate, N-butanol residual aqueous) Clompanus pubescens leaves in streptozotocin (STZ)-induced diabetic rats. Our results revealed significant elevation levels blood glucose, pro-inflammatory cytokines, lipid peroxidation, neuronal...
Presently, many studies have focused on exploring in silico approaches the identification and development of alternative therapy for treatment management cancer. Solute carrier family-2-member-4-gene (Slc2a4) which encodes glucose transporter 4 protein (GLUT4), has been identified as a promising therapeutic target Though Slc2a4 is known to play major regulatory role pathophysiology type 2 diabetes, emerging evidence suggests that successful pharmacological inhibition this may lead novel drug...
This mini review aims to provide an overview of the role telemedicine in preventing multi-drug resistant tuberculosis (MDR-TB) Nigeria. The specific objectives include examining potential benefits telemedicine, identifying challenges associated with its implementation, and highlighting importance addressing infrastructure limitations data privacy concerns.
The burden of human schistosomiasis, a known but neglected tropical disease in Sub-Saharan Africa, has been worrisome recent years. It is becoming increasingly difficult to tackle schistosomiasis with praziquantel, drug be effective against all Schistosoma species, due reports reduced efficacy and resistance. Therefore, this study seeks investigate the antischistosomal potential phytochemicals from Azadirachta indica proteins that have implicated as druggable targets for treatment using...
Currently, there is no known cure for diabetes. Different pharmaceutical therapies have been approved the management of type 2 diabetes mellitus (T2DM), some are in clinical trials and they classified according to their route or mechanism action. Insulin types, sulfonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones, meglitinides, sodium–glucose cotransporter incretin-dependent (glucagon-like peptide-1 receptor agonists: GLP-1R, dipeptidyl peptidase 4 inhibitors: DPP-4)....
Sphenocentrum jollyanum is a major bio-resource used in the folkloric treatment of diabetes, unfortunately without knowledge how or mechanism action. The present study focuses on using molecular docking to identify component responsible for anti-diabetic claim fruit as well check ADMET properties phytochemicals. A library 23 phytochemicals that have been previously characterized from was generated and docked, Autodock Vina, into 3D structures dual-specificity tyrosine phosphorylation...
This study examined the effects of a flavonoid-rich extract Detarium senegalense (FREDS) on haematological parameters and lipid profiles in Streptozotocin (STZ)-induced diabetic rats. A total forty-two (42) rats were randomly assigned to seven groups. All groups, except normal control, administered 45 mg/kg body weight (b.w.) STZ. The treatment groups included: control (normal saline), metformin (100 b.w.), sildenafil three FREDS (50 mg/kg, 75 100 b.w.). Diabetes induction resulted...
Abstract Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta plaques and neurofibrillary tangles composed hyperphosphorylated tau protein. This study computationally investigated natural neem compounds (limonoids) gut microbiome metabolites for their inhibitory potential against key AD targets. Molecular docking analyses were performed on approximately 200 phytochemicals 9 microbial beta-secretase 1 (BACE1), gingipain cysteine protease, oligomerization receptors...
Background/Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the resistant pathogenic microorganisms that poses a global health threat due to its resistance β-lactam antibiotics where protein penicillin-binding 2a (PBP2a) plays crucial role in resistance. This study explores potential phytochemicals from Uvaria chamae, plant with known medicinal properties, serve as dual-site inhibitors PBP2a, targeting both active and allosteric sites. Methods: Phytochemicals...