A5067135972- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Wireless Body Area Networks
- Medicinal Plants and Neuroprotection
- Molecular Communication and Nanonetworks
- Coenzyme Q10 studies and effects
- Cassava research and cyanide
- Garlic and Onion Studies
- Psidium guajava Extracts and Applications
- Natural Compound Pharmacology Studies
- Computational Drug Discovery Methods
- Trace Elements in Health
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
- Phytochemical compounds biological activities
- Biochemical effects in animals
- Sperm and Testicular Function
- Diet and metabolism studies
- Complementary and Alternative Medicine Studies
- Plant Micronutrient Interactions and Effects
- Bioactive natural compounds
- Human Mobility and Location-Based Analysis
- Ginkgo biloba and Cashew Applications
- Aldose Reductase and Taurine
Landmark University
2021-2024
Federal Polytechnic, Nasarawa
2022
The Federal Polytechnic, Ado-Ekiti
2022
The treatment of diabetes involves the use herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract Persea americana seeds (AEPAS) was explored this study as a possible therapeutic agent rats with mellitus. induction achieved by injecting 65 mg/kg body weight (BWt) alloxan along 5% glucose. This conducted using thirty-six (36) male Wistar rats. animals were divided into 6 equal groups, (n = 6) treated for 14 days. In vitro assays total flavonoid,...
Neurodegenerative diseases, for example Alzheimer’s, are perceived as driven by hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, flavonoids, documented in studies having the ability to pass blood-brain barrier moderate development of such illnesses. Computer-aided drug design (CADD) has achieved importance discovery world; innovative developments aspects structure identification characterization, bio-computational science, molecular biology have added...
The management of diabetes over the years has involved use herbal plants, which are now attracting interest. We assessed antidiabetic properties aqueous extract
Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities ethyl acetate fraction Spilanthes filicaulis leaves (EFSFL) via experimental computational studies. Methods: After inducing oxidative damage with FeSO4, we treated tissues different concentrations EFSFL. An in-vitro analysis EFSFL was carried out determine its potential for activities. We also measured levels CAT, SOD, GSH, MDA. Results discussion:...
The purpose of this study was to investigate the therapeutic activity cinnamic acid derivative KAD-3 (ethyl 3-(4-methoxyphenyl) acrylate) on Fe2+-induced oxidative hepatic damage via experimental and computer aided studies. Oxidative induced incubation tissue supernatant with 0.1 mM FeSO4 for 30 min at 37 °C ex vivo different concentration KAD-3. Molecular docking, ADMET profiling, density functional theory were conducted candidate filter properties drug design. GSH, CAT, ENTPDase activities...
The purpose of this study was to investigate the protective effect Beta vulgaris leaf extract (BVLE) on Fe2+-induced oxidative testicular damage via experimental and computational models. Oxidative induced incubation tissue supernatant with 0.1 mM FeSO4 for 30 min at 37 °C. Treatment achieved by incubating tissues BVLE under same conditions. catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) levels, acetylcholinesterase (AChE),...
Erectile dysfunction (ED) is one of the main challenges occurring among men worldwide, and characterised by trouble getting or keeping steady erection during sexual intercourse. Various drugs like sildenafil, a phosphodiesterase-5 inhibitor (PDE-5) are freely available in pharmacies, though normally associated with several adverse. This study was designed to assess molecular relations obtainable between catechin, garcinal, garcinoic acid d-tocotrienol compounds isolated from Garcinia kola...
Type-2 diabetes mellitus (T2DM), is considered being a multifaceted disorder that presents major therapeutic problem. Despite the widespread efforts in managing T2DM, drug discovery therapies remain insufficient. There are several new and vital antidiabetic agents under examination of many research clusters. Computational tools have influenced at levels. Hence, this study aimed to explain molecular interactions via an silico simulation approach between Aframomum melegueta seed-derived...
Abstract Various derivatives of cinnamic acid have been reported to possess significant activities such as antioxidant and hepatoprotective, neuroprotective activities. Interestingly, testicular toxicity has linked several causes, with oxidative damage being one the pathophysiological mechanisms. 3-(4-methoxyphenyl) acrylic ( 1 ), a derivative acid, was synthesized then investigated for its effects on iron-induced injury stress via ex vivo in silico studies, respectively. Evaluations were...
This study explored the flavonoid-rich extract of beetroot ( Beta vulgaris L.) for type 2 diabetes mellitus (T2D) and Alzheimer's disease (AD) dual therapy by using in vitro molecular simulation studies.
Functional foods are that, in addition to providing basic nutrients, have health-promoting effects when ingested consistently over a period of time. These can exist their natural forms or might been enhanced through fortification, biotransformation, genetic modification. Globally, lot attention has drawn its consumption as cheaper and safer remedy for the prevention, treatment, management several health-related conditions, including those reproductive difficulties such infertility....
This work focuses on the clustering in Wireless Body Area Network (WBAN). Recently, it was found that less attention given to Line-of-Sight (LoS) and Non-Line-of-Sight (NLoS) WBAN. Past works LoS WBAN consider problem of enhancing network throughput end-to-end delay network. However, necessary hop count for packet transmission has not been considered. The non-consideration nodes degrades performance cluster-based as is reduced addition high delay. develops a aware body called improved Dual...
This study aimed to examine the therapeutic activity of cinnamic acid derivative KAD-7 (N'-(2,4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe2+-induced oxidative hepatic injury via experimental and computational models. In addition, role ATPase ectonucleoside triphosphate diphosphohydrolase (ENTPDase) in coordination cellular signals is speculated upon proffer suitable therapeutics for metabolic stress disorder their inhibition. While we know little about with flexible dual...
This study investigates the antidiabetic effect of a ketogenic diet (KD) on sucrose-induced insulin resistance in fruit fly model. The flies were divided and grouped into four: Group A, B, C, D, representing control, high-sucrose (HSD), KD, HSD + respectively. administration various treatments to groups proceeded for 7 days. thereafter immobilized, homogenized, homogenates used biochemical parameters determination. includes glucose concentration, antioxidant status,...
Counteraction of adriamycin-induced alterations in cardiac enzymes by Thespesia populnea leaf extractSangeetha Lakshmi A. Rajbanshi, Archana N. Paranjape, Vasu Appanna
Diabetes Mellitus (DM) is a degenerative disease that modifies the body’s glucose metabolism. Although vital energy source for body cells, individuals with diabetes can either not use insulin efficiently or do create enough of this hormone, which controls blood sugar. This review aimed to explore multi-target treatment diabetes. study investigates explicitly recent reports published in peer-reviewed journals indexed various databases, including Web Science, Scopus, PubMed, Google Scholar,...