A5040199224- Moringa oleifera research and applications
- Ethnobotanical and Medicinal Plants Studies
- Essential Oils and Antimicrobial Activity
- Malaria Research and Control
- Sperm and Testicular Function
- Natural Antidiabetic Agents Studies
- Heavy Metal Exposure and Toxicity
- Cannabis and Cannabinoid Research
- Insect Pest Control Strategies
- Exercise and Physiological Responses
- Phytochemical compounds biological activities
- Phytoestrogen effects and research
- Muscle metabolism and nutrition
- GABA and Rice Research
- Traditional and Medicinal Uses of Annonaceae
- Diverse Scientific Research Studies
- Microbial Metabolites in Food Biotechnology
- Pharmacological Effects of Natural Compounds
- Medicinal plant effects and applications
- Toxoplasma gondii Research Studies
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Trace Elements in Health
- Phytochemistry and Bioactivity Studies
Landmark University
2015-2024
Lagos State University
2024
University of Ilorin
2010-2023
Ahmadu Bello University
2023
University Research Co (United States)
2023
Ladoke Akintola University of Technology
2023
Neurodegenerative diseases, for example Alzheimer’s, are perceived as driven by hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, flavonoids, documented in studies having the ability to pass blood-brain barrier moderate development of such illnesses. Computer-aided drug design (CADD) has achieved importance discovery world; innovative developments aspects structure identification characterization, bio-computational science, molecular biology have added...
The Trypanosoma and Toxoplasma spp, are etiological agents of diseases capable causing significant morbidity, mortality economic burden, predominantly in developing countries. Currently, there no effective vaccines for the caused by these parasites; therefore, therapy relies heavily on antiprotozoal drugs. However, treatment options parasitic limited, thus underscoring need new anti-protozoal agents. Here, we investigated anti-parasite action nanoparticles. We found that nanoparticles have...
The management of diabetes over the years has involved use herbal plants, which are now attracting interest. We assessed antidiabetic properties aqueous extract
Ulcerative colitis (UC) is an inflammation of the colon that can progress to colorectal cancer if left untreated. No medication completely cures UC and natural products are sources alternative approaches. This study aimed determine anti-inflammatory potential Phyllanthus nivosus leaf extract fractions in a rat model ulcerative identify active ingredients. was induced rats by intra-rectal infusion 1ml 4% acetic acid (AA) normal saline. AA exposed groups were treated with 100 mg/kg bodyweight...
In Nigeria, Annona muricata L. has been used to treat a variety of ailments. The mechanism the antimalarial activity ethanolic leaf extract (EEAML) was investigated using both an in vivo and silico approach. experimental mice were divided into five groups: A-F. groups B-F inoculated with Plasmodium berghei NK-65 treated accordingly. Groups A B are negative positive controls (infected untreated), respectively. Group C received 10 mg/kg chloroquine (standard drug), whereas D-F 100, 200, 300...
Extracts of Alstonia boonei and Carica papaya are used in herbal medicine for the treatment malaria. This work investigated phytochemical, antioxidant, antimalarial effects hydromethanolic extracts papaya. A four-day chemosuppressive test was conducted to assess ability prevent establishment infection. Three doses were administered-100, 200, 400 mg/kg bw-prior Plasmodium berghei challenge. Change body weight, parasitemia, packed cell volume (PCV), mean survival time determined. three-day...
The emergence of varying levels resistance to currently available antimalarial drugs significantly threatens global health. This factor heightens the urgency explore bioactive compounds from natural products with a view discovering and developing newer novel mode actions. Therefore, we evaluated inhibitory effects sixteen phytocompounds
Allium cepa Linn (Onion) Organosulfuric compounds and phytonutrients have medicinal benefits. The study estimated the antioxidant effect of in fortified feed against oxidative damage caused by potassium bromate. Commercial was substituting 10 %, 20 30 % rat's daily ration with respective portion pulverized cepa. Potassium bromate administered orally to rats all groups except normal control. test were allowed access ad libitum. animals sacrificed; consequently, serum, liver, kidney obtained...
The purpose of this study was to investigate the therapeutic activity cinnamic acid derivative KAD-3 (ethyl 3-(4-methoxyphenyl) acrylate) on Fe2+-induced oxidative hepatic damage via experimental and computer aided studies. Oxidative induced incubation tissue supernatant with 0.1 mM FeSO4 for 30 min at 37 °C ex vivo different concentration KAD-3. Molecular docking, ADMET profiling, density functional theory were conducted candidate filter properties drug design. GSH, CAT, ENTPDase activities...
Abstract Background Exercise-induced oxidative stress is a challenge in equine sports. This study aims at determining the effects of ergothioneine on heat shock protein-70 (HSP-70) following an endurance exercise 30 km by Arabian stallions. Molecular docking was also done to investigate interaction between ligand and using sulfogalactosylceramide sulfogalactoglycerolipid as standards. The involved total 18 clinically healthy stallions, with average age 6.7 ± 2.4 years weight 411.54 12.46 kg....
Erectile dysfunction (ED) is one of the main challenges occurring among men worldwide, and characterised by trouble getting or keeping steady erection during sexual intercourse. Various drugs like sildenafil, a phosphodiesterase-5 inhibitor (PDE-5) are freely available in pharmacies, though normally associated with several adverse. This study was designed to assess molecular relations obtainable between catechin, garcinal, garcinoic acid d-tocotrienol compounds isolated from Garcinia kola...
To evaluated the antioxidant and protective effect of Thaumatococcus daniellii (T. daniellii) on rat feed potassium bromate (KBrO3) toxicity in male testes. Thirty albino rats average weight 140 ± 5 g were randomly grouped into with six per group. The group A (positive control) test groups (C, D E) orally given 0.5 mL 10 mg/kg body KBrO3 daily. animals negative control (group B) positive fed commercial while tests 10%, 20% 30% T. leaf respectively. treatment was carried out for 14 days...
Type-2 diabetes mellitus (T2DM), is considered being a multifaceted disorder that presents major therapeutic problem. Despite the widespread efforts in managing T2DM, drug discovery therapies remain insufficient. There are several new and vital antidiabetic agents under examination of many research clusters. Computational tools have influenced at levels. Hence, this study aimed to explain molecular interactions via an silico simulation approach between Aframomum melegueta seed-derived...
Alcoholism has been linked to problems with male reproductive function. The combined effects of alcohol, cannabis, and tobacco were compared in this study. A total 35 rats assigned randomly into seven groups A-G: animals administered distilled water. Animals B-G either alcohol orally (30 ml 40% alcohol) or exposed smoke from ignited (exposure 0.7 g for 5 min) cannabis min): B (orally alcohol), C (exposed the tobacco), D cannabis), E (treated F G smokes cannabis). Assays carried on testicular...
The antioxidant and hepatoprotective activities of Azadirachta indica (neem) seed protein hydrolysates were investigated. Neem isolate (NSPI) was enzymatically hydrolyzed using pepsin, pancreatin, trypsin. Oxidative hepatic injury (OHI) induced 0.1 mM FeSO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> . Treatment carried out through co-incubation the oxidative tissues with NSPI its hydrolysates. analyzed for glutathione (GSH), nitric...
Essential oils (EOs) are known to possess lethal effects on various pests and insects ecologically safe. The larvicidal adulticidal activities of Helianthus annuus (L.) seed EO (HASEO) against Aedes aegypti mosquitoes in silico inhibitory action its GCMS constituents Ae. acetylcholinesterase (AChE) were investigated. Larvae adult (320 each) grouped into 4 (A - D) exposed DMSO, 1500, 3000 4500 ppm HASEO DMSO respectively. Mortality was recorded after 0, 15, 30 45 min. exhibited stronger...