A5062662077- Ovarian function and disorders
- Diet, Metabolism, and Disease
- Reproductive Biology and Fertility
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Advanced MRI Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Hormonal and reproductive studies
- Tryptophan and brain disorders
- Fatty Acid Research and Health
- Herbal Medicine Research Studies
- Aortic Disease and Treatment Approaches
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Natural Compounds
- Apelin-related biomedical research
- Garlic and Onion Studies
- Nanocluster Synthesis and Applications
- Cholesterol and Lipid Metabolism
- Dietary Effects on Health
- Chemotherapy-induced organ toxicity mitigation
- Pharmacology and Obesity Treatment
Afe Babalola University
2015-2024
Polycystic ovarian syndrome (PCOS) is pathogenically characterized with hyperandrogenism and metabolic alterations, which often result in changes infertility women of reproductive age. Epigenetic have been linked to the development PCOS. However, involvement epigenetic regulator, histone deacetylase (HDAC) PCOS-driven dysfunction not clear. Howbeit, present study hypothesized that acetate, an HDAC inhibitor (HDACi) would protect against experimentally induced PCOS.Female Wistar rats weighing...
The management of diabetes over the years has involved use herbal plants, which are now attracting interest. We assessed antidiabetic properties aqueous extract
The present study was carried out to evaluate the hepatoprotective effects of aqueous extract Xylopia aethiopica stem bark (XASB) on carbon tetrachloride (CCl4) induced liver damage in sprague dawley rats. Experimental rats were randomly divided into four groups five each. Group 1: served as control rats, 2: administered with CCl4 only groundnut oil (1:1) at a dose 3 ml/kg b.wt by single intraperitoneal administration. 3: X. aethopica + ( 250 mg/kg b.wt/day) , 4: treated 500 b.wt/day).Serum...
Over time, diabetes patients usually need combination therapy involving two or more agents, including phytonutrients to attain therapeutic targets. The purpose of this research is elucidate the combined effect metformin and gallic acid (GA) on glucose metabolism, inflammation as well oxidative endoplasmic reticulum (ER) stresses in fructose-fed diabetic rats. Thirty-five rats Wistar strain were arbitrarily distributed into five groups, each containing seven animals follows: normal control,...
Gallic acid and metformin are plant-derived compounds with biological effects. The present study aimed to evaluate the protective effect of gallic hesperidin against aluminium chloride (AlCl3)-induced Alzheimer's disease in Wistar rats. Thirty-five male rats were randomly distributed into seven groups five animals each. Group 1 was administered distilled water only, throughout study. Animals 2-5 received AlCl3 (100 mg/kg/day) Groups 3, 4 5 100 mg/kg/day acid,100 10 donepezil respectively,...
Diabetic neuropathy (DN) is a complex type of diabetes. The underlying cause diabetic nephropathy remains unclear and may be due to variety pathological conditions resulting in kidney failure. This study examines the protective effect methanolic extract Spilanthes filicaulis leaves (MESFL) fructose-fed streptozotocin (STZ)-induced associated pathway.
Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities ethyl acetate fraction Spilanthes filicaulis leaves (EFSFL) via experimental computational studies. Methods: After inducing oxidative damage with FeSO4, we treated tissues different concentrations EFSFL. An in-vitro analysis EFSFL was carried out determine its potential for activities. We also measured levels CAT, SOD, GSH, MDA. Results discussion:...
BackgroundPolycystic Ovarian Syndrome (PCOS) is a multifactorial endocrine-metabolic disorder that highly contributes to the prevalence of infertility globally. The increased consumption refined carbohydrate, particularly fructose has been associated with pandemic metabolic disorders, including in women reproductive age. However, effects high (FRD) on endocrine and disorders PCOS are not clear. Therefore, this study investigated FRD endocrine/metabolic changes letrozole-induced Wistar...
Obesity (OBS) has been established as a link to male hypogonadism with consequent infertility. Previous studies have shown that melatonin (MEL) modulates hypothalamic-pituitary-gonadal function. The present study therefore investigated the hypothesis MEL supplementation would attenuate spermatogenic and steroidogenic dysfunctions associated obesity induced by high-fat diet (HFD). Twenty-four adult Wistar rats (n = 6/group) were used: control group received vehicle (normal saline), obese 40%...
Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against degenerative diseases. The aim of this study was assess the vitro antioxidant activity Ficus asperifolia aqueous extract. In study, radical potential a extract leaves assessed by measuring its capability for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydroxyl (OH), nitric oxide radicals (NO), iron chelation as well reductive ability. Total phenolic flavonoid contents...
Adipose and hepatic metabolic dysfunctions are critical comorbidities that also aggravate insulin resistance in obese individuals. Melatonin is a low-cost agent previous studies suggest its use may promote health. However, effects on some associated with obesity unknown. Herein, we investigated the hypothesis melatonin supplementation would attenuate adipose-hepatic dysfunction high fat diet (HFD)-induced male Wistar rats.Twenty-four adult rats (n = 6/group) were used: Control group received...
This study was designed to investigate the nephroprotective effect and mechanism of action a methanolic extract Petiveria alliacea leaves (MEPAL) in streptozotocin-induced diabetic nephropathy (DN) rats. Twenty-five Wistar rats were randomly distributed into five groups. Type-2 diabetes induced by intraperitoneal injection streptozotocin (40 mg/kg body weight low dose) citrate buffer (pH 4.5) after administering fructose for two weeks. Diabetic with fasting blood glucose above 250 mg/dl...
Objectives: Epilepsy is the most common non-infectious neurologic disease in developing African countries following stroke and Alzheimer's disease. Most conventional antiepileptic drugs, due to their centrally acting potentials have been implicated deregulation of reproductive hormones. This study assessed effect single combined administration vigabatrin (VIG) carbamazepine (CBZ) on pituitary-gonadal axis male Wistar rats.Methods: Fifty rats were randomly divided into 5 groups (n=10). The...
Long-term antiretroviral drug toxicity may exacerbate the impact of HAART-Cyperus esculentus (C. esculentus) interactions on testicular function in HIV-infected individuals. This study examined ability C. plants to treat dysfunction, which is thought be a probable side effect toxicity. Adult Wistar male rats weighing 90–110 g were divided into six groups and administered prescribed treatments. In addition histology stereological parameters, testosterone levels, follicle-stimulating hormone...
The impact of low-dose spironolactone (LSPL) on polycystic ovarian syndrome (PCOS)-associated cardio-renal disorder is unknown. Therefore, the present study hypothesized that LSPL would ameliorate disorders in experimental PCOS animals. Eight-week-old female Wistar rats were allotted into three groups. control group received vehicle (distilled water; per os (p.o.)), letrozole (LET)-treated designated as LET (1 mg/kg; p.o.), and PCOS+LSPL (0.25 mg/kg, p.o.). treatment was done once daily for...
The present study hypothesized that cardiac metabolic inflexibility is dependent on atrial natriuretic peptide/brain peptide (ANP/BNP) alteration and histone deacetylase (HDAC) activity. We further sought to investigate the therapeutic potential of short-chain amino acid (SCFA) acetate in high-fat diet (HFD)-induced obese rat model. Adult male Wistar rats were assigned into groups (n = 6 per group): Control, Obese, Sodium (NaAc)-treated Obese + NaAc-treated received distilled water once...