A5024364229- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Heavy Metal Exposure and Toxicity
- Computational Drug Discovery Methods
- Piperaceae Chemical and Biological Studies
- Metabolism, Diabetes, and Cancer
- Cholinesterase and Neurodegenerative Diseases
- Natural product bioactivities and synthesis
- Moringa oleifera research and applications
- Biochemical Analysis and Sensing Techniques
- Curcumin's Biomedical Applications
- Medicinal Plants and Neuroprotection
- Pancreatic function and diabetes
- Aluminum toxicity and tolerance in plants and animals
- Phytochemistry and Biological Activities
- Ethnobotanical and Medicinal Plants Studies
- Cancer therapeutics and mechanisms
- Advanced Drug Delivery Systems
- Cynara cardunculus studies
- Urban Agriculture and Sustainability
- Apelin-related biomedical research
- Phytochemicals and Medicinal Plants
Afe Babalola University
2014-2025
Universidade Federal do Rio de Janeiro
2024-2025
China Medical University
2021-2024
Bridge University
2023
Federal University Oye Ekiti
2023
University of the Western Cape
2023
International Islamic University Malaysia
2023
Valens Clinics
2023
Adekunle Ajasin University
2021-2022
Institute of Biomedical Science
2021
The escalating prevalence of cancer on a global scale, coupled with the inadequacies present-day therapies and emergence drug-resistant strains, has necessitated development additional anti-cancer drugs. traditional drug discovery process is long complex, high failure rate new drugs in clinical trials further highlights need for computational approaches discovery. Computer-aided design (CADD), including molecular docking, dynamics simulations, QSAR analysis, machine learning, are employed to...
Silver nanoparticles (AgNPs) have been generally used due to their strong antibacterial, antiviral and antifungal antimicrobial properties. However, toxicity is a subject of sustained debate, thus requiring further studies. Hence, this study examines the adverse effects sub-dermal administered dose AgNPs (200 nm) on liver, kidney heart male Wistar rats. Thirty rats were randomly distributed into six groups five animals per group. Group A D served as control received distilled water for 14 28...
In this study, the effect of enzymes involved in degradation renal adenosine and l-arginine was investigated rats exposed to cadmium (Cd) treated with curcumin, principal active phytochemical turmeric rhizome. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, 25 Cd/vehicle, Cd/curcumin mg/kg. The results study revealed that activities deaminase arginase significantly increased Cd-treated when compared control (p < 0.05). However, co-treatment curcumin...
The increasing global burden of diabetes mellitus has called for the search a therapeutic alternative that offers better activities and safety than conventional chemotherapy. Herein, we evaluated neuroprotective antioxidant properties different fractions (ethyl acetate, N-butanol residual aqueous) Clompanus pubescens leaves in streptozotocin (STZ)-induced diabetic rats. Our results revealed significant elevation levels blood glucose, pro-inflammatory cytokines, lipid peroxidation, neuronal...
The quest for novel anti-diabetic medication from medicinal plants is very important since they contain bioactive phytochemicals that offer better activity and safety compared to conventional therapy. In the present study, in vitro, vivo silico approaches were explored evaluate anti-inflammatory, antioxidants, hypoglycemic activities of crude methanol extract Azanza garckeana pulp. Our vitro analysis revealed contains total phenols (260.80 ± 2.23 mg/100 g) flavonoids (10.28 1.29 contents,...
The present study was carried out to evaluate the hepatoprotective effects of aqueous extract Xylopia aethiopica stem bark (XASB) on carbon tetrachloride (CCl4) induced liver damage in sprague dawley rats. Experimental rats were randomly divided into four groups five each. Group 1: served as control rats, 2: administered with CCl4 only groundnut oil (1:1) at a dose 3 ml/kg b.wt by single intraperitoneal administration. 3: X. aethopica + ( 250 mg/kg b.wt/day) , 4: treated 500 b.wt/day).Serum...
Sterculia tragacantha is a medicinal plant commonly used in the western part of Nigeria, for managing diabetes mellitus. However, there dearth scientific information on antidiabetic and neuroprotective properties plant.The silico, vitro vivo models were to evaluate antioxidants, antidiabetic, anti-inflammatory potential aqueous extract leaf (AESTL) streptozotocin (STZ)-induced diabetic rats. Thirty (30) male albino rats (155.34±6.33 g) intraperitoneal injected with 40 mg/kg freshly prepared...
The African nutmeg (Monodora myristica) is a medically useful plant. We, herein, aimed to critically examine whether bioactive compounds identified in the extracted oil of Monodora myristica could act as antimicrobial agents. To this end, we employed Schrödinger platform computational tool screen myristica. Our lead compound displayed highest potency when compared with levofloxacin based on its binding affinity. hit molecule was further subjected an Absorption, Distribution, Metabolism,...
In the present study, in vitro, vivo, and silico models were used to evaluate therapeutic potential of Pulmeria alba methanolic (PAm) extract, we identified major phytocompound, apigetrin. Our vitro studies revealed dose-dependent increased glucose uptake inhibition α-amylase (50% inhibitory concentration (IC50)= 217.19 µg/mL), antioxidant (DPPH, ferric-reducing activity plasma (FRAP), lipid peroxidation (LPO) [IC50 = 103.23, 58.72, 114.16 µg/mL respectively]), anti-inflammatory (stabilizes...
The continual increase in global diabetic statistics portends decreased productivity and life spans, thus making it a disease of concern requiring more effective safe therapeutic options. While several reports on antidiabetic plants, including Hura crepitans, are available, there is still dearth information the holistic properties H. crepitans its associated complications. This study evaluated potential methanolic extract using vitro, vivo, silico approaches. revealed dose-dependent vitro...
Abstract BACKGROUND Gongronema latifolium ( G. ) Benth. leaves are traditionally used to treat diabetes mellitus (DM) and other diseases in Nigeria West Africa. This study was performed evaluate the neuroprotective effect of aqueous extract leaf against DM. Antidiabetic activity extracts (6.36, 12.72 25.44 mg kg −1 , i.p.) determined alloxan‐induced diabetic rats. Fasting blood glucose level oxidative stress markers catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx),...
The present study evaluated the polyphenolic contents and hypoglycemic, antioxidant, anti-inflammatory effects of diethyl ether fraction Thespesia garckeana using various in vitro vivo models. Total phenol flavonoid extract were <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mn>613.65</a:mn> <a:mo>±</a:mo> <a:mn>2.38</a:mn> </a:math> <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mn>152.83</c:mn> <c:mo>±</c:mo> <c:mn>1.56</c:mn> </c:math> mg/100 g dry...
Glucokinase plays an important role in regulating the blood glucose level and serves as essential therapeutic target type 2 diabetes management. Entada africana is a medicinal plant highly rich source of bioactive ligands with potency to develop new drugs for glucokinase such obesity. Therefore, study explored computational approach predict identified compounds from following its intermolecular interactions allosteric binding site enzymes. We retrieved three-dimensional (3D) crystal...
Context:Gongronema latifolium Benth (Asclepiadaceae) has been highly utilized in controlling diabetes mellitus traditionally the eastern part of Nigeria. Objectives: Antihyperglycaemic and related gene expressions aqueous extract Gongronema leaf alloxan-induced diabetic rats. Materials methods: Forty-eight female Wistar rats were induced intraperitoneally using alloxan (150 mg/kg body weight). The separated into six groups (n = 8) as follows: non-diabetic control, administered 5 weight...
The current study evaluated the protective role of Solanum torvum Swartz against diabetes-induced oxidative stress and tissue impairment in streptozotocin (STZ)-intoxicated rats. Rats with STZ (40 mg/kg intraperitoneally (i.p.))-induced diabetes were divided into five groups (n = 5) treated (i) normal saline, (ii) 150 body weight (BW) ethanol extract S. leaf (EESTL), 300 BW EESTL, (iv) 100 metformin, (v) 50 m/kg metformin + EESTL orally for 21 days. Our results revealed that displayed...
Effect of Aframomum melegueta on carbon tetrachloride induced liver injuryIdoh Kokou, Karou S. Damintoti, Agbonon Amegnona, Adjrah Yao, Gbeassor Messanvi
Tridax procumbens (cotton buttons) is a flowering plant with medicinal reputation for treating infections, wounds, diabetes, and liver kidney diseases. The present research was conducted to evaluate the possible protective effects of T. methanolic extract (TPME) on an experimentally induced type 2 diabetes rat model. Wistar rats streptozotocin (STZ)-induced were randomly allocated into five groups animals each, viz., normal glycemic group (I), diabetic receiving distilled water (II), 150...