A5041629565- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Natural Antidiabetic Agents Studies
- Click Chemistry and Applications
- Food Science and Nutritional Studies
- Hemoglobinopathies and Related Disorders
- African Botany and Ecology Studies
- Polyomavirus and related diseases
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Diet, Metabolism, and Disease
- Toxin Mechanisms and Immunotoxins
- Moringa oleifera research and applications
- Medicinal Plants and Neuroprotection
- Hibiscus Plant Research Studies
- DNA and Nucleic Acid Chemistry
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Diverse Scientific Research Studies
University of Alabama at Birmingham
2023-2024
Michael Okpara University of Agriculture
2020-2024
University of Bath
2020-2023
Clifford University
2023
Bridge University
2023
The escalating prevalence of cancer on a global scale, coupled with the inadequacies present-day therapies and emergence drug-resistant strains, has necessitated development additional anti-cancer drugs. traditional drug discovery process is long complex, high failure rate new drugs in clinical trials further highlights need for computational approaches discovery. Computer-aided design (CADD), including molecular docking, dynamics simulations, QSAR analysis, machine learning, are employed to...
Background/Objectives: Ketone esters (KEs) exhibit promise as anti-cancer agents but their impact on spontaneous metastases remains poorly understood. Although consumption of a ketogenic diet (KD) that is low in carbohydrates and high fats can lead to KE production vivo, the restrictive composition KDs may diminish adherence cancer patients. Methods: We investigated effects an exogenous ketone ester-supplemented (eKET), carbohydrate-replete tumor growth, metastasis, underlying mechanisms...
Aim: This study aims to evaluate the antibacterial activity of Moringa, Neem, and Ginger plant extracts on bacteria species isolated from fruit juice samples.
 Place Duration Study: Department Microbiology, Michael Okpara University Agriculture, Umudike, Abia State, Nigeria, between October 2019 November 2019.
 Methods: The sample was prepared cultured Mannitol Salt Agar (MSA), Eosin Methylene Blue (EMB), Salmonella Shigella (SSA), Blood using streak plate techniques. Four (4) were...
Most patients with complex malignancies show a high level of toxicity and limited long-lasting responses to current conventional therapies. In contrast, the immune system has intrinsic potential distinguish between self non-self (foreign or different) cells, including cancer successfully eliminate them. Even after T NK cells navigate sophisticated surveillance paths studded diversion networks, processes, impediments, they must overcome impacts highly neutralizing immune-suppressive...
Abstract Obesity is linked to an increased risk of various cancers, including renal cell carcinoma (RCC). Many RCC patients have obesity at diagnosis and treatment initiation, our lab has found that this significantly impairs immunotherapy outcomes. Both preclinical clinical reports, from others, demonstrated reduces the efficacy CD8+ T cell-dependent by increasing pro-tumorigenic IL-1β. Combining anti-PD-1 based therapy with anti-IL-1β triggers recruitment cells improves immunotherapy....
This study aimed to investigate the effects of Acioa barteri extract (ABE) on hepatocellular enzyme activity, hepatic function, and antioxidant stress indices in diabetic rats induced with alloxan. The antidiabetic effect ABE was evaluated six experimental groups: normal controls, diabetics untreated, treated 200mg/kg, 400mg/kg, or 800 mg/kg ABE, 3 Glibenclamide. orally administered induce diabetes, alloxan-monohydrate intraperitoneally administered. Diabetic untreated exhibited...
Background: Carica papaya is commonly used in the treatment of various diseases like constipation, piles, hypertension and malaria. The ameliorative effect on alloxan-induced diabetic rats has been suggested by several studies.
 Aim: present study aims to investigate methanolic extract unripe pulp lipid profile liver biomarkers a rat.
 Materials Methods: After acclimatization, thirty-two (32) animals were randomly classified into 8 groups (4 per group). different test (extract)...
Aim: The present study was carried out to investigate the antimicrobial, cytotoxic, and anti-inflammatory activities of aqueous stem extract Loranthus micranthus (African mistletoe) plant.
 Methods: Disc agar diffusion method used for antimicrobial susceptibility test organisms determine minimum zone inhibition. brine shrimp lethality in determining cytotoxicity, heat-induced membrane indices.
 Results: In this study, activity evaluated using Escherichia Coli., Salmonella typhi,...
<title>Abstract</title> Background:<italic>Aju Mbaise</italic>is a combination of herbs that is widely used in the southeast part Nigeria for purpose managing postpartum complications and alleviating menstrual pain. The study aimed at assessing analgesic, anti-inflammatory, anti-diarrheal properties of<italic>Aju mbaise</italic>extract rats. Methods: extract was subjected to phytochemical analysis acute toxicity testing. Subsequently, effects were evaluated by administering charcoal as meal...
Aim: To evaluate the nephrotoxic and hepatotoxic potentials of artesunate in humans.
 Place Duration Study: Department Biochemistry, Michael Okpara University Agriculture, Umudike, Abia State, Nigeria, between November December 2019.
 Methodology: 70 blood samples were collected from 35 normal individuals (control group), malaria patients treated with parenteral (treatment group). These analyzed for biochemical parameters, including urea nitrogen (BUN), creatinine, total bilirubin,...