A5014713358- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Polyomavirus and related diseases
- HIV/AIDS drug development and treatment
- Free Radicals and Antioxidants
- Vibrio bacteria research studies
- Hemoglobinopathies and Related Disorders
- Synthesis and biological activity
- DNA and Nucleic Acid Chemistry
- Plant Virus Research Studies
- Phytoplasmas and Hemiptera pathogens
- Research on Leishmaniasis Studies
- Genomics and Phylogenetic Studies
- COVID-19 epidemiological studies
- Bacteriophages and microbial interactions
- Vaccine Coverage and Hesitancy
Ladoke Akintola University of Technology
2022-2025
Abstract Background Breast cancer, particularly the human epidermal growth factor receptor 2 positive subtype, presents a significant global health challenge due to its high prevalence and mortality rates. This study delves into molecular intricacies of HER-2 breast with an emphasis on role oncoprotein associated signaling pathways in cell growth, differentiation, survival. In our pursuit overcoming limitations one leading therapeutic options, Lapatinib, such as inhibition hERG, we embarked...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has imposed substantial challenges on our society due to the COVID-19 pandemic. This virus relies heavily its surface glycoprotein (S-glycoprotein) facilitate attachment, fusion, and entry into host cells. While nucleoprotein (N) in ribonucleoprotein core binds viral RNA genome. Therefore, objective is develop a novel vaccine candidate targeting dominant T-cell B-cell epitopes of immune system. On S-glycoprotein nucleoprotein....
Schistosoma haematobium has been identified as a significant cause of urogenital disease, well risk factor for bladder cancer and HIV/AIDS. The parasites are obtained trans-dermally by swimming or wading in contaminated freshwater, they also transmitted to humans freshwater snails. organisms infect the vasculature gastrointestinal genitourinary tracts. Worms live blood vessels lay eggs that become embedded wall, causing chronic immune-mediated disease squamous cell carcinoma growth. primary...
Messenger RNA (mRNA) vaccines emerged as a powerful tool in the fight against infections. Unlike traditional vaccines, this unique type of vaccine elicits robust and persistent innate humoral immune response with host cell-mediated pathogen gene expression antigen presentation.
Abstract The enzyme Heme O Synthase (HOS) is essential for producing heme A and O, which are critical defense against reactive oxygen species, drug detoxification, gas synthesis, transport, electron transport in Plasmodium species . It has become vital to discover inhibitory molecules/compounds/medicines that target the synthesis of due emergence drug‐resistant strains falciparum Therefore, this study, we employed molecular mechanics with Generalized Born surface area (MMGBSA) calculations...
The available Epstein Barr virus vaccine has tirelessly harnessed the gp350 glycoprotein as its target epitope, but result not been preventive. Right here, we designed a global multi-epitope for EBV; with special attention to making sure all strains and preventive antigens are covered. Using robust computational design approach, our proposed is armed 6–16 mers linear B-cell epitopes, 4–9 mer CTL 8–15 HTL epitopes which verified induce interleukin 4, 10 & IFN-gamma. We employed deep mining...
Loiasis is caused by Loa loa, a vector-borne filarial parasitic worm endemic to Central and West Africa. It significant public health issue due its geographic overlap with Onchocerciasis Lymphatic Filariasis. has been reported that improper diagnosis of can complicate the treatment Filariasis, causing severe neurological reactions. Due this, there’s need for more sensitive method detect loa in humans.Hence, study aimed predict design novel, synthetic multi-epitope protein diagnosingLoiasis...
ABSTRACT The Key participants in the calcium signaling process malaria parasite are dependent protein kinases. It has been established that Plasmodium falciparum kinase 1 ( Pf CDPK1) is essential for invasion of host erythrocytes as well parasite’s asexual development. Due to malaria’s resistance currently available anti-malarial medications, it become necessary create effective inhibitory agents target invasion-dependent proteins. In this study, libraries 856 chemicals were screened using a...