A5081389183- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Phytochemical Studies and Bioactivities
- Air Quality and Health Impacts
- Diverse Scientific Research Studies
- Genomics, phytochemicals, and oxidative stress
- Traditional and Medicinal Uses of Annonaceae
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Bioactive Compounds
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Biological Activities
- Medicinal Plant Extracts Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Metabolism, Diabetes, and Cancer
- vaccines and immunoinformatics approaches
- Cocoa and Sweet Potato Agronomy
Federal University of Technology
2013-2025
Bioscience Research
2024-2025
Adekunle Ajasin University
2013-2020
Universidade Federal de Santa Maria
2013-2019
Ekiti State University
2013-2017
Creative Research Enterprises (United States)
2017
Universidade Regional do Cariri
2017
University of Science and Technology of Benin
2017
Kingsley House
2017
The escalating prevalence of cancer on a global scale, coupled with the inadequacies present-day therapies and emergence drug-resistant strains, has necessitated development additional anti-cancer drugs. traditional drug discovery process is long complex, high failure rate new drugs in clinical trials further highlights need for computational approaches discovery. Computer-aided design (CADD), including molecular docking, dynamics simulations, QSAR analysis, machine learning, are employed to...
SARS-CoV-2 is a new strain of Coronavirus that caused the pneumonia outbreak in Wuhan, China and has spread to over 200 countries world. It received worldwide attention due its virulence high rate infection. So far, several drugs have experimented against SARS-CoV-2, but failure these specifically interact with viral protease necessitates urgent measure boost up researches for development effective therapeutics SARS-CoV-2. Papain-like (PLpro) polyproteins essential maturation infectivity...
The present study evaluates the hypoglycemic, antiperoxidative and antihyperlipidemic activities of saponins from Solanum anguivi fruits in alloxan induced diabetes rats. Diabetic rats were treated with saponin (20–100 mg/kg) for 21 days. Results indicated that administration significantly reduced elevated levels glucose, decreased total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) increased high (HDL) serum towards normalcy when compared to diabetic control (p <...
Abstract Background Apoptosis-signaling kinase 1 is a MAPKKK (mitogen-activated protein kinase) overexpressed in various types of human cancer including colorectal cancer. It mediates inflammation and apoptosis promotes cell proliferation through the transcription cyclin D1. 5-Fluorouracil remains one primary recommended drugs to manage However, this drug often causes adverse effects, notably diarrhea, vomiting, nausea, leukopenia. Therefore, novel treatment required eradicate these...
Abstract Background The second most seen malignancy occurrence among males is prostate cancer. p90 ribosomal s6 kinase (RSK) has attracted increased attention due to its overexpression in cancer cells, especially cells. Significant progress been made recently develop RSK inhibitors treat cancer, but these efforts have shown limited success. Methods Molecular docking and other computational analysis procedures using the Schrodinger suite were used predict silico ability of bioactive compounds...
Background: Glycogen synthase kinase 3-beta (GSK3-β) is a protein that linked to the formation of amyloid-beta (Aβ) plaques and neurofibrillary tangles, both which are characteristic Alzheimer's disease. The enzyme's hyperactivity phosphorylates tau proteins, forming tangles impair material transport between axons dendrites disrupt neuronal function. GSK3-β impacts amyloid precursor production, causing Aβ accumulation neurodegeneration. Aim/Objective: This study aimed investigate inhibitory...
To evaluate the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG) its possible effect on mitochondrial permeability transition pore as well membrane potential (ΔΨm) isolated from rat liver. Antioxidant activity SAG was assayed by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, iron chelation ability to inhibit lipid peroxidation in both liver brain homogenate rats. Also, swelling were determined. Identification quantification bioactive polyphenolics...
Momordica charantia (bitter lemon) belongs to the cucurbitaceae family which has been extensively used in traditional medicines for cure of various ailments such as cancer and diabetes. The underlying mechanism M. maintain glycemic control was investigated. GLP-1 DPP-4 gene modulation by (5-20% inclusion rats diet) investigated vivo RT-PCR possible compounds responsible diabetic action predicted through silico approach. Phytochemicalss previously characterized from were docked into glucacon...
Annona muricata has been used in folklore the management of diabetes. A major strategy decreasing postprandial hyperglycemia diabetes involves inhibition carbohydrate-hydrolyzing enzymes - α-amylase and α-glucosidase. Thus, this study evaluated vivo vitro inhibitory potentials different parts (fruit-pulp, leaf, stem-bark root-bark) muricata. total 120 Wistar rats were treated with methanol extracts for 28 days after which blood tissue samples collected assay. In properties methanol, ethyl...
Visfatin (Nicotinamide phosphoribosyltransferase) is an adipokine implicated in mediating insulin resistance and exhibiting mimetic effect therefore represents a druggable target for diabetes therapy. About 3,844 peroxisome proliferator activated receptor gamma (PPARγ) agonists documented Chembl database were docked with PPARγ those binding energy of >−9 kcal/mol having experimental EC50 0.1 to 1 nM selected. The candidate compounds (27) thereafter visfatin (PDB ID: 4WQ6) using AutodockVina...
Studies have shown that diesel exhaust particles (DEP) induced oxidative stress and inflammation. This present study examined the molecular effects of aqueous rooibos extract (RE) on cardiovascular toxic effect methanol DEP in exposed Wistar rats. The results showed caused significant (p < 0.001) increase MDA CDs levels aorta heart but this was significantly attenuated by extract. IL-8, TNFα, IL-1β decreased IL-10 gene expressions, all which were reversed presence expression NF-κB, IκKB...